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Pain wind-up is the perceived increase in pain intensity over time when a given painful stimulus is delivered repeatedly above a critical rate. It is caused by repeated stimulation of group C peripheral nerve fibers, leading to progressively increasing electrical response in the corresponding spinal cord (posterior horn) neurons.
- ↑ (29 May 2011) Introduction to Skin Biothermomechanics and Thermal Pain, Springer. URL accessed 25 April 2012.
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