Weber's syndrome
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| ICD-10 | G463 | |
|---|---|---|
| ICD-9 | 344.89 | |
| OMIM | [1] | |
| DiseasesDB | 31247 | |
| MedlinePlus | [2] | |
| eMedicine | / | |
| MeSH | {{{MeshNumber}}} | |
Weber's syndrome (superior alternating hemiplegia) is a form of stroke characterized by the presence of an oculomotor nerve palsy and contralateral hemiparesis or hemiplegia.
Contents |
Cause and presentation
Edit
This lesion is usually unilateral and affects several structures in the midbrain including:
| Structure damaged | Effect |
|---|---|
| substantia nigra | contralateral parkinsonism because its dopaminergic projections to the basal ganglia innervate the ipsilateral hemisphere motor field, leading to a movement disorder of the contralateral body. |
| corticospinal fibers | contralateral hemiparesis and typical upper motor neuron findings. It is contralateral because it occurs before the decussation in the medulla. |
| corticobulbar tract | difficulty with contralateral lower facial muscles and hypoglossal nerve functions |
| oculomotor nerve fibers | ipsilateral oculomotor nerve palsy with a drooping eyelid and fixed wide pupil pointed down and out. This leads to diplopia |
It is caused by midbrain infarction as a result of occlusion of the paramedian branches of the posterior cerebral artery or of basilar bifurcation perforating arteries.[1]
HistoryEdit
It carries the name of Sir Hermann David Weber, a German-born physician working in London, who described the condition in 1863.[2][3] It is unrelated to Sturge-Weber syndrome or Klippel-Trenaunay-Weber syndrome.
ReferencesEdit
- ↑ GPnotebook -932511721
- ↑ Weber HD (1863). A contribution to the pathology of the crura cerebri. Medico-Chirurgical Transactions 46: 121–139.
- ↑ Template:Whonamedit
External linksEdit
Template:Lesions of spinal cord and brainstem
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