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Vinblastine chemical structure
| dimethyl (2β,3β,4β,5α,12β,19α)-15-[(5S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3,4-dicarboxylate|
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|Molecular weight||810.974 g/mol|
|Elimination half-life||24.8 hours (terminal)|
|Excretion||Biliary and renal|
|Routes of administration||Exclusively intravenous|
Vinblastine was first isolated by Robert Noble and Charles Thomas Beer from the Madagascar periwinkle plant. Vinblastine's utility as a chemotherapeutic agent was first discovered when it was crushed into a tea. Consumption of the tea led to a decreased number of white blood cells; therefore, it was hypothesized that vinblastine might be effective against cancers of the white blood cells such as lymphoma.
Vinblastine is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting the assembly of microtubules. It is M phase cell cycle specific since microtubules are a component of the mitotic spindle and the kinetochore which are necessary for the separation of chromosomes during anaphase of mitosis. Toxicities include bone marrow suppression (which is dose-limiting), gastrointestinal toxicity, potent vesicant (blister-forming) activity, and extravasation injury (forms deep ulcers).
Vinblastine paracrystals may be composed of tightly-packed unpolymerized tubulin or microtubules.
Vinblastine is a component of a number of chemotherapy regimens, including ABVD for Hodgkin lymphoma. It is also used to treat histiocytosis according to the established protocols of the Histiocytosis Association of America.
- ↑ Starling D (Jan 1976). Two ultrastructurally distinct tubulin paracrystals induced in sea-urchin eggs by vinblastine sulphate.. J Cell Sci 20 (1): 79–89.
- Bell, G. A., & Morgan, I. G. (1981). The effects of colchicine and vinblastine on memory in chicks: Behavioural Brain Research Vol 2(3) May 1981, 301-322.
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