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Vinblastine chemical structure
| dimethyl (2β,3β,4β,5α,12β,19α)-15-[(5S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3,4-dicarboxylate|
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|Molecular weight||810.974 g/mol|
|Elimination half-life||24.8 hours (terminal)|
|Excretion||Biliary and renal|
|Routes of administration||Exclusively intravenous|
Vinblastine is an anti-mitotic drug used as an antineoplastic drug to treat certain kinds of cancer, including Hodgkin's lymphoma, non-small cell lung cancer, breast cancer, head and neck cancer, and testicular cancer.
Vinblastine was first isolated by Robert Noble and Charles Thomas Beer from the Madagascar periwinkle plant. Vinblastine's utility as a chemotherapeutic agent was first discovered when it was crushed into a tea. Consumption of the tea led to a decreased number of white blood cells; therefore, it was hypothesized that vinblastine might be effective against cancers of the white blood cells such as lymphoma.
Vinblastine is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting the assembly of microtubules. It is M phase cell cycle specific since microtubules are a component of the mitotic spindle and the kinetochore which are necessary for the separation of chromosomes during anaphase of mitosis. Toxicities include bone marrow suppression (which is dose-limiting), gastrointestinal toxicity, potent vesicant (blister-forming) activity, and extravasation injury (forms deep ulcers).
Vinblastine paracrystals may be composed of tightly-packed unpolymerized tubulin or microtubules.
Vinblastine is a component of a number of chemotherapy regimens, including ABVD for Hodgkin lymphoma. It is also used to treat histiocytosis according to the established protocols of the Histiocytosis Association of America.
- ↑ Starling D (Jan 1976). Two ultrastructurally distinct tubulin paracrystals induced in sea-urchin eggs by vinblastine sulphate.. J Cell Sci 20 (1): 79–89.
- Bell, G. A., & Morgan, I. G. (1981). The effects of colchicine and vinblastine on memory in chicks: Behavioural Brain Research Vol 2(3) May 1981, 301-322.
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