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Vesicular monoamine transporter

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solute carrier family 18 (vesicular monoamine), member 1
Symbol(s): SLC18A1 VMAT1, VAT1
Locus: 8 p21.3
EC number [1]
EntrezGene 6570
OMIM 193002
RefSeq NM_003053
UniProt P54219
solute carrier family 18 (vesicular monoamine), member 2
Symbol(s): SLC18A2 VMAT2
Locus: 10 q25
EC number [2]
EntrezGene 6571
OMIM 193001
RefSeq NM_003054
UniProt Q05940

The vesicular monoamine transporter is a transport protein located within the presynaptic cell. It comprises the two isoforms VMAT1 and VMAT2.

VMAT2 Edit

Impairment and Dysfunction Edit

Cocaine users display a marked reduction in VMAT2 immunoreactivity. Suffers of cocaine-induced mood disorders displayed a significant loss of VMAT2 immunoreactivity, this might reflect damage to striatal dopamine fibers. These neuronal changes could play a role in causing disordered mood and motivational processes in more severely addicted users.[1]

Binding Sites and Ligands Edit

One binding site is that of DTBZ. Lobeline binds at this site. At a distinct site dextroamphetamine binds. Its activity at VMAT2 is a crucial part of its monoamine releasing action.

References Edit

  1. K.Y. Little et al. (2003). Am J Psychiatry 160, 47-55. Loss of Striatal Vesicular Monoamine Transporter Protein (VMAT2) in Human Cocaine Users

Further reading Edit

  • Kilbourne, M.R. (1997) In Vivo Radiotracers for Vesicular Neurotransmitter Transporters. Nuclear Medicine & Biology, Vol.24, pp.615-619.
  • Weihe, E. and Eiden, L.E. (2000) Chemical neuroanatomy of the vesicular amine transporter. FASEB J, Vol.14, pp.2435-2449.

External linksEdit

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