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(Created page with "{{BioPsy}} {{Drugbox | Verifiedfields = changed | verifiedrevid = 402863818 | IUPAC_name = [(2''S'',3''S'',5''S'',8''R'',9''S'',10''S'',13''S'',14''S'',16''S'',17''S'')-<br>17-ac...")
 
 
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'''Vecuronium''' ('''Norcuron''') is a [[muscle relaxant]] in the category of [[non-depolarizing blocking agent]]s. Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate [[endotracheal intubation]] and to provide skeletal muscle relaxation during surgery or mechanical
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'''Vecuronium''' ('''Norcuron''') is a [[muscle relaxant]] in the category of [[non-depolarizing blocking agent]]s. Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical
 
ventilation. Although vecuronium bromide is often thought of as a muscle relaxant, it may be more accurate to classify it as a paralyzing agent. It is commercially available as ampoules containing 4 mg of the drug in powder form which needs to be dissolved in distilled water prior to administration to the patient. In India, vials containing 10 mg of vecuronium bromide are also commercially available, for use in patients undergoing prolonged surgical procedures.
  
ventilation. Although vecuronium bromide is often thought of as a muscle relaxant, it may be more accurate to classify it as a paralyzing agent. It is commercially available as ampoules containing 4 mg of the drug in powder form which needs to be dissolved in distilled water prior to administration to the patient. In India, vials containing 10 mg of vecuronium bromide are also commercially available, for use in patients undergoing prolonged surgical procedures.
   
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Vecuronium is an [[aminosteroid]].
  
Vecuronium is an [[aminosteroid]].
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== In the news ==
  
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In 2001, Japanese nurse [[Daisuke Mori]] was reported to have murdered 10 patients using vecuronium bromide.<ref>{{cite news|url=http://www.expressindia.com/news/ie/daily/20010111/iin11054.html|title=Japanese nurse kills 10 patients, says wanted to trouble hospital|publisher=[[The Indian Express]]|date=2001-01-10|accessdate=2008-03-22}}</ref> He was convicted of murder and was sentenced to [[life imprisonment]].<ref>{{cite news|url=http://www.breitbart.com/article.php?id=D8V2JI400&show_article=1|title=Top court dismisses appeal by ex-nurse over Sendai clinic murder|publisher=Breitbart.com|date=2008-02-27|accessdate=2008-03-22}}</ref>
  
   
 
== See also ==
  
== See also ==
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[[ru:Векурония бромид]]
  
[[ru:Векурония бромид]]
 
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{{enWP|Vecuronium bromide}}

Latest revision as of 17:38, September 11, 2011

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Vecuronium bromide chemical structure
Vecuronium bromide

[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17S)-
17-acetyloxy-10,13-dimethyl-16-(1-methyl-3,4,
5,6-tetrahydro-2H-pyridin-1-yl)-2-(1-piperidyl)-
2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-
1H-cyclopenta[a]phenanthren-3-yl] acetate
IUPAC name
CAS number
50700-72-6 		ATC code

M03AC03

PubChem
39765 		DrugBank
{{{DrugBank}}}
Chemical formula {{{chemical_formula}}}
Molecular weight 557.827 g/mol
Bioavailability 100% (IV)
Metabolism liver 30%
Elimination half-life 51–80 minutes (longer with renal failure)
Excretion Fecal (40-75%) and renal (30% as unchanged drug and metabolites)
Pregnancy category {{{pregnancy_category}}}
Legal status
Routes of administration Intravenous


Vecuronium (Norcuron) is a muscle relaxant in the category of non-depolarizing blocking agents. Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Although vecuronium bromide is often thought of as a muscle relaxant, it may be more accurate to classify it as a paralyzing agent. It is commercially available as ampoules containing 4 mg of the drug in powder form which needs to be dissolved in distilled water prior to administration to the patient. In India, vials containing 10 mg of vecuronium bromide are also commercially available, for use in patients undergoing prolonged surgical procedures.

Contents

DevelopmentEdit

Vecuronium's structure is derived from the same aminosteroid structure as pancuronium, but it is missing the methyl group on the piperidine nitrogen that is attached to the 'A' ring, making it monoquaternary, like D-tubocurarine. This means it is less potent than pancuronium as a neuromuscular blocking agent. It has the same configuration at all ten stereocentres as pancuronium, and is a single-isomer preparation.

Clinical pharmacology Edit

Vecuronium operates by competing for the cholinoceptors at the motor end plate thereby exerting its muscle-relaxing properties which are used adjunctively to general anesthesia. Under balanced anesthesia, the time to recovery to 25% of control (clinical duration) is approximately 25 to 40 minutes after injection and recovery is usually 95% complete approximately 45 to 65 minutes after injection of intubating dose. The neuromuscular blocking action of vecuronium is slightly enhanced in the presence of potent inhalation anesthetics. If vecuronium is first administered more than 5 minutes after the start of the inhalation of enflurane, isoflurane, or halothane, or when a steady state has been achieved, the intubating dose of vecuronium may be decreased by approximately 15%.

Vecuronium is an aminosteroid.

See also Edit

References Edit


v·d·e
Muscle relaxants (M03)
Peripherally acting
(primarily antinicotinic,
neuromuscular-blocking drugs)

curare alkaloids (Alcuronium, Dimethyltubocurarine, Tubocurarine) - choline derivatives (Suxamethonium) - other quaternary ammonium compounds (Atracurium, Cisatracurium, Doxacurium chloride, Fazadinium bromide, Gallamine, Hexafluronium, Mivacurium chloride, Pancuronium, Pipecuronium bromide, Rocuronium bromide, Vecuronium) - other (Botulinum toxin)

Centrally acting

carbamic acid esters (Phenprobamate, Carisoprodol, Methocarbamol, Styramate, Febarbamate), Baclofen, Chlormezanone, Chlorzoxazone, Cyclobenzaprine, Lorazepam, Mephenesin, Orphenadrine, Phenyramidol, Pridinol, Tetrazepam, Thiocolchicoside, Tizanidine, Tolperisone

Directly acting

Dantrolene


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