VMAT2
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| solute carrier family 18 (vesicular monoamine), member 2 | |
|---|---|
| Symbol(s): | SLC18A2 VMAT2 |
| Locus: | 10 q25 |
| EC number | [1] |
| EntrezGene | 6571 |
| OMIM | 193001 |
| RefSeq | NM_003054 |
| UniProt | Q05940 |
A study by the National Cancer Institute on over 200 subjects (including twins), has identified the VMAT2 gene to correlate to spirituality and religion. It was led by the geneticist Dean Hamer.[1][2]
Contents |
[edit] Impairment and dysfunction
Cocaine users display a marked reduction in VMAT2 immunoreactivity. Suffers of cocaine-induced mood disorders displayed a significant loss of VMAT2 immunoreactivity, this might reflect damage to striatal dopamine fibers. These neuronal changes could play a role in causing disordered mood and motivational processes in more severely addicted users.[3]
[edit] Binding sites and ligands
One binding site is that of DTBZ. Lobeline binds at this site. At a distinct site dextroamphetamine binds. Its activity at VMAT2 is a crucial part of its monoamine releasing action.
[edit] Role in mental heath
[edit] References
- ↑ Day, Elizabeth 'God gene' discovered by scientist behind gay DNA theory. Telegraph. Telegraph Media Group Limited. URL accessed on 2007-04-08.
- ↑ Kluger, Jeffrey, Jeff Chu, Broward Liston, Maggie Sieger, Daniel Williams Is God in our genes?. TIME. Time Inc.. URL accessed on 2007-04-08.
- ↑ Little, Karley Y., David M. Krolewski, Lian Zhang, Bader J. Cassin (2003-01-01). Loss of striatal vesicular monoamine transporter protein (VMAT2) in human cocaine users. American journal of psychiatry 160: pp. 47-55. 10.1176/appi.ajp.160.1.47.
[edit] See also
[edit] External link
Glutamate - Monoamine (DAT, NET, SERT) - Vesicular monoamine (VMAT1, VMAT2) - Vesicular acetylcholine
Membrane proteins, carrier proteins: membrane transport proteins | |
|---|---|
| ABC-transporter | A1, A12, B1, B2-3, B4, B5, B11, C4, C6, C8-9, D1, E1 |
| Solute carrier | 1A1-7, 1A3, 2A1, 2A2, 2A3, 2A4, 3A1, 3A2, 4A1, 5A1-2, 5A5, 6A2, 6A3, 6A4, 7A5, 7A9, 8A1-3, 9A3, 11A2, 12A1-2, 12A3, 17A6-8, 18A1, 18A2, 18A3, 19A2, 19A3, 22A5, 24A1-2, 24A5, 25A4-6, 25A13, 25A15, 25A20, 26A2, 26A4, 34A1, 39A4, 40A1 |
| Monosaccharide | GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT8 |
| Other | Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Karyopherin) |
| This page uses content from the English-language version of Wikipedia. The original article was at VMAT2. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License. |
