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'''Uveitis''' specifically refers to [[inflammation]] of the middle layer of the [[eye]], termed the "[[uvea]]" but in common usage may refer to any inflammatory process involving the interior of the eye.
 
'''Uveitis''' specifically refers to [[inflammation]] of the middle layer of the [[eye]], termed the "[[uvea]]" but in common usage may refer to any inflammatory process involving the interior of the eye.
   
Uveitis is estimated to be responsible for approximately 10% of the blindness in the United States.{{fact}} Uveitis requires an urgent referal and thorough examination by an [[ophthalmologist]] or [[optometrist]], along with urgent treatment to control the inflammation.
+
Uveitis is estimated to be responsible for approximately 10% of the blindness in the United States.{{fact}} Uveitis requires an urgent referral and thorough examination by an [[ophthalmologist]] or [[optometrist]], along with urgent treatment to control the inflammation.
   
 
==Types==
 
==Types==
 
Uveitis is usually categorized anatomically into ''anterior'', ''intermediate'', ''posterior'' and ''panuveitic'' forms.
 
Uveitis is usually categorized anatomically into ''anterior'', ''intermediate'', ''posterior'' and ''panuveitic'' forms.
   
* Anywhere from two-thirds to 90% of uveitis cases are anterior in location (anterior uveitis), frequently termed ''[[iritis]]'' - or inflammation of the [[Iris (anatomy)|iris]] and [[anterior chamber]]. This condition can occur as a single episode and subside with proper treatment or may take on a recurrent or chronic nature. Symptoms include [[red eye (medicine)|red eye]], injected [[conjunctiva]], pain and decreased vision. Signs include dilated [[ciliary vessel]]s, presence of cells and flare in the anterior chamber, and keratic precipitates ("KP") on the posterior surface of the [[cornea]].
+
* Anywhere from two-thirds to 90% of uveitis cases are anterior in location (anterior uveitis), frequently termed ''[[iritis]]'' - or inflammation of the [[Iris (anatomy)|iris]] and [[anterior chamber]]. This condition can occur as a single episode and subside with proper treatment or may take on a recurrent or chronic nature. Symptoms include [[red eye (medicine)|red eye]], injected [[conjunctiva]], pain and decreased vision. Signs include dilated [[ciliary vessel]]s, presence of cells and flare in the anterior chamber, and keratic precipitates ("KP") on the posterior surface of the [[cornea]].
 
* [[Intermediate uveitis]] consists of vitritis - inflammatory cells in the [[vitreous humour|vitreous cavity]], sometimes with ''snowbanking'', or deposition of inflammatory material on the [[pars plana]].
 
* [[Intermediate uveitis]] consists of vitritis - inflammatory cells in the [[vitreous humour|vitreous cavity]], sometimes with ''snowbanking'', or deposition of inflammatory material on the [[pars plana]].
* Posterior uveitis is the inflammation of the [[retina]] and [[choroid]].
+
* Posterior uveitis is the inflammation of the [[retina]] and [[choroid]].
 
* Pan-uveitis is the inflammation of all the layers of the uvea.
 
* Pan-uveitis is the inflammation of all the layers of the uvea.
   
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Systemic disorders that can cause uveitis include: White G. [http://www.allaboutvision.com/conditions/uveitis.htm "Uveitis."] AllAboutVision.com. Retrieved August 20, 2006.</ref>
 
Systemic disorders that can cause uveitis include: White G. [http://www.allaboutvision.com/conditions/uveitis.htm "Uveitis."] AllAboutVision.com. Retrieved August 20, 2006.</ref>
 
*[[Acute posterior multifocal placoid pigment epitheliopathy]]
 
*[[Acute posterior multifocal placoid pigment epitheliopathy]]
*[[Ankylosing spondylitis]]
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*[[Ankylosing spondylitis]]
*[[Behçet's disease]]
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*[[Behçet's disease]]
*[[Birdshot retinochoroidopathy]]
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*[[Birdshot retinochoroidopathy]]
*[[Brucellosis]]
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*[[Brucellosis]]
*[[Herpes simplex]]
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*[[Herpes simplex]]
*[[Herpes zoster]]
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*[[Herpes zoster]]
*[[Inflammatory bowel disease]]
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*[[Inflammatory bowel disease]]
*[[Juvenile rheumatoid arthritis]]
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*[[Juvenile rheumatoid arthritis]]
*[[Kawasaki's disease]]
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*[[Kawasaki's disease]]
*[[Leptospirosis]]
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*[[Leptospirosis]]
 
*[[Lyme disease]]
 
*[[Lyme disease]]
*[[Multiple sclerosis]]
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*[[Multiple sclerosis]]
*[[Presumed ocular histoplasmosis syndrome]]
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*[[Presumed ocular histoplasmosis syndrome]]
*[[Psoriatic arthritis]]
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*[[Psoriatic arthritis]]
*[[Reiter's syndrome]]
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*[[Reiter's syndrome]]
*[[Sarcoidosis]]
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*[[Sarcoidosis]]
*[[Syphilis]]
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*[[Syphilis]]
*[[Systemic lupus erythematosus]]
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*[[Systemic lupus erythematosus]]
*[[Toxocariasis]]
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*[[Toxocariasis]]
*[[Toxoplasmosis]]
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*[[Toxoplasmosis]]
*[[Tuberculosis]]
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*[[Tuberculosis]]
 
*[[Vogt-Koyanagi-Harada syndrome]]
 
*[[Vogt-Koyanagi-Harada syndrome]]
   

Latest revision as of 23:02, September 23, 2012

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Hypopyon.jpg|
Uveitis
ICD-10 H20
ICD-9 364
OMIM {{{OMIM}}}
DiseasesDB 13676
MedlinePlus {{{MedlinePlus}}}
eMedicine oph/580 emerg/284
MeSH {{{MeshNumber}}}

Uveitis specifically refers to inflammation of the middle layer of the eye, termed the "uvea" but in common usage may refer to any inflammatory process involving the interior of the eye.

Uveitis is estimated to be responsible for approximately 10% of the blindness in the United States.[How to reference and link to summary or text] Uveitis requires an urgent referral and thorough examination by an ophthalmologist or optometrist, along with urgent treatment to control the inflammation.

TypesEdit

Uveitis is usually categorized anatomically into anterior, intermediate, posterior and panuveitic forms.

  • Anywhere from two-thirds to 90% of uveitis cases are anterior in location (anterior uveitis), frequently termed iritis - or inflammation of the iris and anterior chamber. This condition can occur as a single episode and subside with proper treatment or may take on a recurrent or chronic nature. Symptoms include red eye, injected conjunctiva, pain and decreased vision. Signs include dilated ciliary vessels, presence of cells and flare in the anterior chamber, and keratic precipitates ("KP") on the posterior surface of the cornea.
  • Intermediate uveitis consists of vitritis - inflammatory cells in the vitreous cavity, sometimes with snowbanking, or deposition of inflammatory material on the pars plana.
  • Posterior uveitis is the inflammation of the retina and choroid.
  • Pan-uveitis is the inflammation of all the layers of the uvea.

CausesEdit

A myriad of conditions can lead to the development of uveitis, including systemic diseases as well as syndromes confined to the eye. In anterior uveitis, no specific diagnosis is made in approximately one-half of cases. However, anterior uveitis is often one of the syndromes associated with HLA-B27.

Systemic disorders causing uveitisEdit

Systemic disorders that can cause uveitis include: White G. "Uveitis." AllAboutVision.com. Retrieved August 20, 2006.</ref>

Masquerade syndromesEdit

Masquerade syndromes are ophthalmic disorders that clinically present as either an anterior or posterior uveitis, but are not primarily inflammatory. The following are some of the most common:

  • Anterior segment
  • Posterior segment
  • Lymphoma
  • Malignant melanoma
  • Multiple sclerosis
  • Reticulum cell sarcoma
  • Retinitis pigmentosa
  • Retinoblastoma

SymptomsEdit

  • Redness of the eye
  • Blurred vision
  • Sensitivity to light
  • Dark, floating spots in the vision
  • Eye pain

TreatmentEdit

The prognosis is generally good for those who receive prompt diagnosis and treatment, but serious complication (including cataracts, glaucoma, band keratopathy, retinal edema and permanent vision loss) may result if left untreated. The type of uveitis, as well as its severity, duration, and responsiveness to treatment or any associated illnesses, all factor in to the outlook.[1]

Uveitis is typically treated with glucocorticoid steroids, either as topical eye drops (such as betamethasone, dexamethasone or prednisolone) or oral therapy with prednisolone tablets. In addition topical cycloplegics, such as atropine or homatropine, may be used.[1]

Antimetabolite medications, such as methotrexate are often used for recalcitrant or more aggressive cases of uveitis. Experimental treatment with Infliximab infusions may prove helpful.

See alsoEdit

FootnotesEdit

  1. BNF 45 March 2003

External linksEdit

es:Uveítis fr:Uvéite nl:Uveïtis

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