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Urocortin is a protein that in humans is encoded by the UCN gene. This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain, it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. Urocortin is a potent anorexigenic peptide of 40 amino acids that induces fed-like motor activity when administered centrally or peripherally in fasted animals. Urocortin belongs to the corticotropin-releasing factor (CRF) family that includes CRF, urotensin I, sauvagine, urocortin II and urocortin III. Urocortin is also a potent and long-lasting hypotensive agent and increases coronary blood flow.
- ↑ Zhao L, Donaldson CJ, Smith GW, Vale WW (April 1999). The structures of the mouse and human urocortin genes (Ucn and UCN). Genomics 50 (1): 23–33.
- ↑ Tsarev OB (July 1977). [Dynamics of matrix synthesis in molecular biophysics. II. Principle of insertability and the single-valued solution of feedback tasks]. Biofizika 22 (2): 197–200.
- ↑ 3.0 3.1 Entrez Gene: UCN urocortin.
- ↑ Donaldson, C J, Sutton S W, Perrin M H, Corrigan A Z, Lewis K A, Rivier J E, Vaughan J M, Vale W W (May. 1996). Cloning and characterization of human urocortin. Endocrinology 137 (5): 2167–70.
- ↑ Gottowik, J, Goetschy V, Henriot S, Kitas E, Fluhman B, Clerc R G, Moreau J L, Monsma F J, Kilpatrick G J (October 1997). Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin. Neuropharmacology 36 (10): 1439–46.
- Inui, Bowers, et al. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J. 2004 Mar;18(3):439-56. [http://www.fasebj.org/cgi/content/full/18/3/439
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