Wikia

Psychology Wiki

Changes: Tyrosine hydroxylase

Edit

Back to page

 
 
Line 3: Line 3:
   
 
The enzyme is found in the cytosol of all cells containing [[catecholamines]]. This initial reaction is the rate limiting step in the production of catecholamines.
 
The enzyme is found in the cytosol of all cells containing [[catecholamines]]. This initial reaction is the rate limiting step in the production of catecholamines.
The enzyme is highly specific, not accepting indole derivatives - which is unusual as many other enzymes involved in the production of catecholamines do.
+
The enzyme is highly specific, not accepting [[indole]] derivatives - which is unusual as many other enzymes involved in the production of catecholamines do.
   
Tyrosine hydroxylase can be inhibited by the drug α-methyl tyrosine ([[Metirosine]]), however it is not an effective means of regulating noreadrenaline synthesis. This drug is rarely used, but it is useful in treating phaeochromocytoma ([[pheochromocytoma]])and also resistant [[hypertension]].
+
Tyrosine hydroxylase can be inhibited by the drug α-methyl tyrosine ([[Metirosine]]), however it is not an effective means of regulating [[noreadrenaline]] synthesis. This drug is rarely used, but it is useful in treating phaeochromocytoma ([[pheochromocytoma]])and also resistant [[hypertension]].
   
 
==References==
 
==References==

Latest revision as of 15:40, January 23, 2007

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


Tyrosine hydroxylase is the enzyme responsible for catalyzing the conversion of L-tyrosine, an amino acid, to dihydroxyphenylalanine (DOPA), a precursor to dopamine.

The enzyme is found in the cytosol of all cells containing catecholamines. This initial reaction is the rate limiting step in the production of catecholamines. The enzyme is highly specific, not accepting indole derivatives - which is unusual as many other enzymes involved in the production of catecholamines do.

Tyrosine hydroxylase can be inhibited by the drug α-methyl tyrosine (Metirosine), however it is not an effective means of regulating noreadrenaline synthesis. This drug is rarely used, but it is useful in treating phaeochromocytoma (pheochromocytoma)and also resistant hypertension.

ReferencesEdit

  • Pharmacology 5th Ed, by Rang, Dale Ritter and Moore

External linksEdit

Around Wikia's network

Random Wiki