Ad blocker interference detected!
Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers
Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.
Individual differences |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |
Developmental Psychology: Cognitive development · Development of the self · Emotional development · Language development · Moral development · Perceptual development · Personality development · Psychosocial development · Social development · Developmental measures
A twin registry is a database of information about both identical twins and fraternal twins, which is often maintained by an academic institution, such as a university, or by other research institutions.
The use of twins can improve the statistical power of a genetic study by reducing the amount of genetic and/or environmental variability. "Identical twins" (monozygotic (MZ) twins) share virtually all their genes with each other, and "fraternal twins" (dizygotic (DZ) twins), on average, share about 50% of their genes with each other (about the same amount of sharing as non-twin siblings). Both types of twin pairs in twin registries almost always share similar prenatal and early childhood environments as well. By determining what are called "concordance" rates for a disease or trait among identical and fraternal twin pairs, researchers can estimate whether contributing factors for that disease or trait are more likely to be hereditary, environmental, or some combination of these. A concordance rate is a statistical measure of probability - if one twin has a specific trait or disease, what is the probability that the other twin has (or will develop) that same trait or disease. In addition, with structural equation modeling and multivariate analyses of twin data, researchers can offer estimates of the extent to which allelic variants and environment may influence phenotypic traits.
Some twin registries seek to cover all twins in an entire country, including Sweden, Denmark, Norway, Finland, Australia, Sri Lanka and the United Kingdom. The Swedish Twin Registry is the largest twin database in the world, with approximately 85,000 twin pairs.
Other twin registries cover a more limited geographic scope and are maintained by researchers at academic institutions, such as the Michigan State University Twin Registry, a registry of twins produced by researchers at Michigan State University and the Minnesota Twin Registry project by researchers at the University of Minnesota related to the Minnesota Twin Family Study. The largest twin registry in the United States is the Mid-Atlantic Twin Registry (MATR) at Virginia Commonwealth University, which has more than 51,000 registered participants, with approximately 46,000 of these representing intact twin pairs.
Many twin registries depend on the voluntary participation of twins – that is, participation in these twin registries is not compulsory, and twins must voluntarily elect whether or not to register with a twin registry (and later, whether to participate in research projects). This characteristic limitation of many twin registries leads to standard issues known as "recruitment bias" or "volunteer bias". Recruitment biases include an over-inclusion of twins who share similar characteristics, and over-inclusion of identical twins and female twins:
- "[T]his recruitment bias ... results in ... overestimation of the true heritability of the trait under study."
Twin registries use a number of strategies to try to reduce the risk of recruitment bias. Some twin registries are "mandatory" - that is, for example, under the public health laws of Norway, all births of twins since 1967 have been recorded in a twin registry maintained by the Norwegian government. By comparison, enlisting with the Australian Twin Registry is voluntary. While the twin registry in Sri Lanka is based on volunteer twins, that twin registry has made extensive out-reach efforts, such as examining hospital birth records, and then making multiple follow-up efforts (including in-person visits) to find the twins and have them (or their parents) agree to be registered.
- ↑ 1.0 1.1 1.2 1.3 NIEHS Twin Registry accessed 2013-06-14. (Some of the text in this article is a close paraphrase of the material on this website maintained by the U.S. Federal Government,and which is a document in the public domain.)
- ↑ 2.0 2.1 Swedish Twin Registry accessed 2013-06-14
- ↑ Danish Twin Registry accessed 2013-06-14
- ↑ 4.0 4.1 4.2 Tambs, Rønning et al.; "The Norwegian Institute of Public Health Twin Study of Mental Health: Examining Recruitment and Attrition Bias" Twin Res Hum Genet. 2009 April; 12(2): 158–168. doi: 10.1375/twin.12.2.158. Accessed 2013-06-14
- ↑ Australian Twin Registry accessed 2013-06-14
- ↑ Sri Lanka Twin Registry accessed 2013-06-14
- ↑ U.K. Twin Registry accessed 2013-06-14
- ↑ D. T. Lykken, M. McGue, A. Tellegen; "Recruitment bias in twin research: The rule of two-thirds reconsidered"; Behavior Genetics:vol. 17, no. 4, pp. 343-362, 1987. DOI: 10.1007/BF01068136 Accessed 2013-06-14
- ↑ 9.0 9.1 D. T. Lykken, A. Tellegen & R. DeRubeis; "Volunteer bias in twin research: The rule of two‐thirds" Biodemography and Social Biology:Volume 25, Issue 1, 1978. Accessed 2013-06-14
- ↑ Australian Twin Registry registration "With over 70,000 members the ATR has become the largest volunteer registry of multiples in the world. Nevertheless, this still only represents about 10% – 15% of twins in Australia and we need more recruits!" Accessed 2013-06-16.
- ↑ Siribaddana SH, Siriwardane WD, et al. "Update from Sri Lankan Twin Registry" Twin Res Hum Genet. 2006 Dec;9(6):868-74.
|This page uses Creative Commons Licensed content from Wikipedia (view authors).|