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Turner Syndrome
Classification and external resources
Template:Px
Girl with Turner syndrome before and immediately after her operation for neck-webbing which is a characteristic clinical feature of patients with the syndrome
ICD-10 Q96
ICD-9 758.6
DiseasesDB 13461
MedlinePlus 000379
eMedicine ped/2330
MeSH D014424

Turner syndrome or Ullrich-Turner syndrome (also known as "Gonadal dysgenesis"[1]:550) encompasses several conditions, of which monosomy X (absence of an entire sex chromosome, the Barr body) is most common. It is a chromosomal abnormality in which all or part of one of the sex chromosomes is absent (unaffected humans have 46 chromosomes, of which two are sex chromosomes). Typical females have two X chromosomes, but in Turner syndrome, one of those sex chromosomes is missing or has other abnormalities. In some cases, the chromosome is missing in some cells but not others, a condition referred to as mosaicism[2] or 'Turner mosaicism'.

Occurring in 1 in 2000[3] – 1 in 5000 phenotypic females,[4] the syndrome manifests itself in a number of ways. There are characteristic physical abnormalities, such as short stature, swelling, broad chest, low hairline, low-set ears, and webbed necks.[5] Girls with Turner syndrome typically experience gonadal dysfunction (non-working ovaries), which results in amenorrhea (absence of menstrual cycle) and sterility. Concurrent health concerns are also frequently present, including congenital heart disease, hypothyroidism (reduced hormone secretion by the thyroid), diabetes, vision problems, hearing concerns, and many autoimmune diseases.[6] Finally, a specific pattern of cognitive deficits is often observed, with particular difficulties in visuospatial, mathematical, and memory areas.[7]

Turner's syndrome is named after Henry H. Turner.

Signs and symptoms[]

File:Puffy feet.JPG

Lymphedema, puffy legs of a newborn with Turner syndrome

Common symptoms of Turner syndrome include:

  • Short stature
  • Lymphedema (swelling) of the hands and feet
  • Broad chest (shield chest) and widely spaced nipples
  • Low hairline
  • Low-set ears
  • Reproductive sterility
  • Rudimentary ovaries gonadal streak (underdeveloped gonadal structures)
  • Amenorrhoea, or the absence of a menstrual period
  • Increased weight, obesity
  • Shield shaped thorax of heart
  • Shortened metacarpal IV
  • Small fingernails
  • Characteristic facial features
  • Webbed neck from cystic hygroma in infancy
  • Coarctation of the aorta
  • Bicuspid aortic valve
  • Poor breast development
  • Horseshoe kidney
  • Visual impairments sclera, cornea, glaucoma, etc.
  • Ear infections and hearing loss
  • High waist-to-hip ratio (the hips are not much bigger than the waist)
  • Attention Deficit/Hyperactivity Disorder (problems with concentration, memory and attention)
  • Nonverbal Learning Disability (problems with math, social skills and spatial relations)

Other symptoms may include a small lower jaw (micrognathia), cubitus valgus (turned-in elbows), soft upturned nails, palmar crease, and drooping eyelids. Less common are pigmented moles, hearing loss, and a high-arch palate (narrow maxilla). Turner syndrome manifests itself differently in each female affected by the condition, and no two individuals will share the same symptoms.

Cause[]

Risk factors for Turner syndrome are not well known. Genetic mosaicism (46XX/45XO) is most often implicated, alongside nondisjunction (45XO) and partial monosomy (46XX). Nondisjunctions increase with maternal age, such as for Down syndrome, but that effect is not clear for Turner syndrome. It is also unknown if there is a genetic predisposition present that causes the abnormality, though most researchers and doctors treating Turners women agree that this is highly unlikely. In 75% of cases inactivated X chromosome is paternal origin. There is currently no known cause for Turner syndrome, though there are several theories surrounding the subject. The only solid fact that is known today is that during conception part or all of the second sex chromosome is not transferred to the fetus.[8] In other words, these females do not have Barr bodies, which are those X chromosomes inactivated by the cell.

Diagnosis[]

File:45,X.jpg

45,X karyotype, showing an unpaired X at the lower right

Turner syndrome may be diagnosed by amniocentesis during pregnancy. Sometimes, fetuses with Turner syndrome are identified by abnormal ultrasound findings (i.e. heart defect, kidney abnormality, cystic hygroma, ascites). Although the recurrence risk is not increased, genetic counseling is often recommended for families who have had a pregnancy or child with Turner syndrome.

A test, called a karyotype or a chromosome analysis, analyzes the chromosomal composition of the individual. This is the test of choice to diagnose Turner syndrome.

Prognosis[]

While most of the physical findings are harmless, there can be significant medical problems associated with the syndrome.

Cardiovascular[]

Price et al. (1986 study of 156 female patients with Turner syndrome) showed a significantly greater number of deaths from diseases of the circulatory system than expected, half of them due to congenital heart defects—mostly preductal coarctation of the aorta. When patients with congenital heart disease were omitted from the sample of the study, the mortality from circulatory disorders was not significantly increased.[9]

Cardiovascular malformations are a serious concern as it is the most common cause of death in adults with Turner syndrome. It takes an important part in the 3-fold increase in overall mortality and the reduced life expectancy (up to 13 years) associated with Turner syndrome.

Cause[]

According to Sybert, 1998 the data are inadequate to allow conclusions about phenotype-karyotype correlations in regard to cardiovascular malformations in Turner syndrome because the number of individuals studied within the less common karyotype groups is too small. Other studies also suggest the presence of hidden mosaicisms that are not diagnosed on usual karyotypic analyses in some patients with 45,X karyotype.

In conclusion, the associations between karyotype and phenotypic characteristics, including cardiovascular malformations, remain questionable.

Prevalence of cardiovascular malformations[]

The prevalence of cardiovascular malformations among patients with Turner syndrome ranges from 17% (Landin-Wilhelmsen et al., 2001) to 45% (Dawson-Falk et al., 1992).

The variations found in the different studies are mainly attributable to variations in non-invasive methods used for screening and the types of lesions that they can characterize (Ho et al., 2004). However Sybert, 1998 suggests that it could be simply attributable to the small number of subjects in most studies.

Different karyotypes may have differing prevalence of cardiovascular malformations. Two studies found a prevalence of cardiovascular malformations of 30%[10] and 38%[11] in a group of pure 45,X monosomy. But considering other karyotype groups, they reported a prevalence of 24.3%[10] and 11%[11] in patients with mosaic X monosomy , and a prevalence of 11% in patients with X chromosomal structural abnormalities.[10]

The higher prevalence in the group of pure 45,X monosomy is primarily due to a significant difference in the prevalence of aortic valve abnormalities and coarctation of the aorta, the two most common cardiovascular malformations.

Congenital heart disease[]

The most commonly observed are congenital obstructive lesions of the left side of the heart, leading to reduced flow on this side of the heart. This includes bicuspid aortic valve and coarctation (narrowing) of the aorta. Sybert, 1998 found that more than 50% of the cardiovascular malformations observed in her study of individuals with Turner syndrome were bicuspid aortic valves or coarctation of the aorta, alone or in combination.

Other congenital cardiovascular malformations, such as partial anomalous venous drainage and aortic valve stenosis or aortic regurgitation, are also more common in Turner syndrome than in the general population. Hypoplastic left heart syndrome represents the most severe reduction in left-sided structures

Bicuspid aortic valve[]

Up to 15% of adults with Turner syndrome have bicuspid aortic valves, meaning that there are only two, instead of three, parts to the valves in the main blood vessel leading from the heart. Since bicuspid valves are capable of regulating blood flow properly, this condition may go undetected without regular screening. However, bicuspid valves are more likely to deteriorate and later fail. Calcification also occurs in the valves,[12] which may lead to a progressive valvular dysfunction as evidenced by aortic stenosis or regurgitation.[13]

With a prevalence from 12.5%[10] to 17.5% (Dawson-Falk et al., 1992), bicuspid aortic valve is the most common congenital malformation affecting the heart in this syndrome. It is usually isolated but it may be seen in combination with other anomalies, particularly coarctation of the aorta.

Coarctation of the aorta[]

Between 5% and 10% of those born with Turner syndrome have coarctation of the aorta, a congenital narrowing of the descending aorta, usually just distal to the origin of the left subclavian artery (the artery that branches off the arch of the aorta to the left arm) and opposite to the duct (and so termed "juxtaductal"). Estimates of the prevalence of this malformation in patients with Turner syndrome ranges from 6.9%[10] to 12.5% (Dawson-Falk et al., 1992). A coarctation of the aorta in a female is suggestive of Turner syndrome, and suggests the need for further tests, such as a karyotype.

Partial anomalous venous drainage[]

This abnormality is a relatively rare congenital heart disease in the general population. The prevalence of this abnormality also is low (around 2.9%) in Turner syndrome. However, its relative risk is 320 in comparison with the general population. Strangely, Turner syndrome seems to be associated with unusual forms of partial anomalous venous drainage.[10][14]

In the management of a patient with Turner syndrome it is essential to keep in mind that these left-sided cardiovascular malformations in Turner syndrome result in an increased susceptibility to bacterial endocarditis. Therefore prophylactic antibiotics should be considered when procedures with high risk endocarditis are performed, such as dental cleaning.[13]

Turner syndrome is often associated with persistent hypertension, sometimes in childhood. In the majority of Turner syndrome patients with hypertension, there is no specific cause. In the remainder, it is usually associated with cardiovascular or kidney abnormalities, including coarctation of the aorta.

Aortic dilation, dissection, and rupture[]

Two studies have suggested aortic dilatation in Turner syndrome, typically involving the root of the ascending aorta and occasionally extending through the aortic arch to the descending aorta, or at the site of previous coarctation of the aorta repair.[15]

  • Allen et al., 1986 who evaluated 28 girls with Turner syndrome, found a significantly greater mean aortic root diameter in patients with Turner syndrome than in the control group (matched for body surface area). Nonetheless, the aortic root diameter found in Turner syndrome patients were still well within the limits.[16]
  • This has been confirmed by the study of Dawson-Falk et al., 1992 who evaluated 40 patients with Turner syndrome.[17] They presented basically the same findings: a greater mean aortic root diameter, which nevertheless remains within the normal range for body surface area.

Sybert, 1998 points out that it remains unproven that aortic root diameters that are relatively large for body surface area but still well within normal limits imply a risk for progressive dilatation.[18]

Prevalence of aortic abnormalities[]

The prevalence of aortic root dilatation ranges from 8.8%[15] to 42%[13] in patients with Turner syndrome. Even if not every aortic root dilatation necessarily goes on to an aortic dissection (circumferential or transverse tear of the intima), complications such as dissection, aortic rupture resulting in death may occur. The natural history of aortic root dilatation is still unknown, but it is a fact that it is linked to aortic dissection and rupture, which has a high mortality rate.[19]

Aortic dissection affects 1% to 2% of patients with Turner syndrome. As a result any aortic root dilatation should be seriously taken into account as it could become a fatal aortic dissection. Routine surveillance is highly recommended.[13]

Risk factors for aortic rupture[]

It is well established that cardiovascular malformations (typically bicuspid aortic valve, coarctation of the aorta and some other left-sided cardiac malformations) and hypertension predispose to aortic dilatation and dissection in the general population. At the same time it has been shown that these risk factors are common in Turner syndrome. Indeed these same risk factors are found in more than 90% of patients with Turner syndrome who develop aortic dilatation. Only a small number of patients (around 10%) have no apparent predisposing risk factors. It is important to note that the risk of hypertension is increased 3-fold in patients with Turner syndrome. Because of its relation to aortic dissection blood pressure needs to be regularly monitored and hypertension should be treated aggressively with an aim to keep blood pressure below 140/80 mmHg. It has to be noted that as with the other cardiovascular malformations, complications of aortic dilatation is commonly associated with 45,X karyotype.[13]

Pathogenesis of aortic dissection and rupture[]

The exact role that all these risk factors play in the process leading to such fatal complications is still quite unclear. Aortic root dilatation is thought to be due to a mesenchymal defect as pathological evidence of cystic medial necrosis has been found by several studies. The association between a similar defect and aortic dilatation is well established in such conditions such as Marfan syndrome. Also, abnormalities in other mesenchymal tissues (bone matrix and lymphatic vessels) suggests a similar primary mesenchymal defect in patients with Turner syndrome.[15] However there is no evidence to suggest that patients with Turner syndrome have a significantly higher risk of aortic dilatation and dissection in absence of predisposing factors. So the risk of aortic dissection in Turner syndrome appears to be a consequence of structural cardiovascular malformations and hemodynamic risk factors rather than a reflection of an inherent abnormality in connective tissue (Sybert, 1998). The natural history of aortic root dilatation is unknown, but because of its lethal potential, this aortic abnormality needs to be carefully followed.

Pregnancy[]

Turner syndrome is characterized by primary amenorrhea, premature ovarian failure, streak gonads and infertility. However, technology (especially oocyte donation) provide the opportunity of pregnancy in these patients.

As more women with Turner syndrome complete pregnancy thanks to modern techniques to treat infertility, it has to be noted that pregnancy may be a risk of cardiovascular complications for the mother. Indeed several studies had suggested an increased risk for aortic dissection in pregnancy.[15] Three deaths have even been reported. The influence of estrogen has been examined but remains unclear. It seems that the high risk of aortic dissection during pregnancy in women with Turner syndrome may be due to the increased hemodynamic load rather than the high estrogen rate.[13] Of course these findings are important and need to be remembered while following a pregnant patient with Turner syndrome.

Cardiovascular malformations in Turner syndrome are also very serious, not only because of their high prevalence in that particular population but mainly because of their high lethal potential and their great implication in the increased mortality found in patients with Turner syndrome. Congenital heart disease needs to be explored in every female newly diagnosed with Turner syndrome. As adults are concerned close surveillance of blood pressure is needed to avoid a high risk of fatal complications due to aortic dissection and rupture.

Skeletal[]

Normal skeletal development is inhibited due to a large variety of factors, mostly hormonal. The average height of a woman with Turner syndrome, in the absence of growth hormone treatment, is 4 ft 7 in (140 cm). Patients with Turner's mosaicism can reach normal average height.

The fourth metacarpal bone (fourth toe and ring finger) may be unusually short, as may the fifth.

Due to inadequate production of estrogen, many of those with Turner syndrome develop osteoporosis. This can decrease height further, as well as exacerbate the curvature of the spine, possibly leading to scoliosis. It is also associated with an increased risk of bone fractures.

Kidney[]

Approximately one-third of all women with Turner syndrome have one of three kidney abnormalities:

  1. A single, horseshoe-shaped kidney on one side of the body.
  2. An abnormal urine-collecting system.
  3. Poor blood flow to the kidneys.

Some of these conditions can be corrected surgically. Even with these abnormalities, the kidneys of most women with Turner syndrome function normally. However, as noted above, kidney problems may be associated with hypertension.

Thyroid[]

Approximately one-third of all women with Turner syndrome have a thyroid disorder. [citation needed] Usually it is hypothyroidism, specifically Hashimoto's thyroiditis. If detected, it can be easily treated with thyroid hormone supplements.

Diabetes[]

Women with Turner syndrome are at a moderately increased risk of developing type 1 diabetes in childhood and a substantially increased risk of developing type 2 diabetes by adult years. The risk of developing type 2 diabetes can be substantially reduced by maintaining a normal weight.

Cognitive[]

Turner syndrome does not typically cause mental retardation or impair cognition. However, learning difficulties are common among women with Turner syndrome, particularly a specific difficulty in perceiving spatial relationships, such as nonverbal learning disorder. This may also manifest itself as a difficulty with motor control or with mathematics. While it is non-correctable, in most cases it does not cause difficulty in daily living. Most Turner Syndrome patients are employed as adults and lead productive lives.

There is also a rare variety of Turner Syndrome, known as "Ring-X Turner Syndrome", which has an approximate 60 percent association with mental retardation. This variety accounts for approximately 2–4% of all Turner Syndrome cases.[20]

Reproductive[]

Women with Turner syndrome are almost universally infertile. While some women with Turner syndrome have successfully become pregnant and carried their pregnancies to term, this is very rare and is generally limited to those women whose karyotypes are not 45,X.[21][22] Even when such pregnancies do occur, there is a higher than average risk of miscarriage or birth defects, including Turner Syndrome or Down Syndrome.[23] Some women with Turner syndrome who are unable to conceive without medical intervention may be able to use IVF or other fertility treatments.[24]

Usually estrogen replacement therapy is used to spur growth of secondary sexual characteristics at the time when puberty should onset. While very few women with Turner Syndrome menstruate spontaneously, estrogen therapy requires a regular shedding of the uterine lining ("withdrawal bleeding") to prevent its overgrowth. Withdrawal bleeding can be induced monthly, like menstruation, or less often, usually every three months, if the patient desires. Estrogen therapy does not make a woman with nonfunctional ovaries fertile, but it plays an important role in assisted reproduction; the health of the uterus must be maintained with estrogen if an eligible woman with Turner Syndrome wishes to use IVF (using donated oocytes).

Turner syndrome is a cause of primary amenorrhea, premature ovarian failure (hypergonadotropic hypogonadism), streak gonads and infertility. Failure to develop secondary sex characteristics (sexual infantilism) is typical.

Especially in mosaic cases of Turner syndrome that contains Y-chromosome (e.g. 45,X0/46,XY) due to the risk of development of ovarian malignancy (most common is gonadoblastoma) gonadectomy is recommended.[citation needed]

Treatment[]

As a chromosomal condition, there is no cure for Turner syndrome. However, much can be done to minimize the symptoms. For example:[25]

  • Growth hormone, either alone or with a low dose of androgen, will increase growth and probably final adult height. Growth hormone is approved by the U.S. Food and Drug Administration for treatment of Turner syndrome and is covered by many insurance plans.[25][26] There is evidence that this is effective, even in toddlers.[27]
  • Estrogen replacement therapy has been used since the condition was described in 1938 to promote development of secondary sexual characteristics. Estrogens are crucial for maintaining good bone integrity and tissue health.[25] Women with Turner Syndrome who do not have spontaneous puberty and who are not treated with estrogen are at high risk for osteoporosis.
  • Modern reproductive technologies have also been used to help women with Turner syndrome become pregnant if they desire. For example, a donor egg can be used to create an embryo, which is carried by the Turner syndrome woman.[25]
  • Uterine maturity is positively associated with years of estrogen use, history of spontaneous menarche, and negatively associated with the lack of current hormone replacement therapy.[28]

Epidemiology[]

Approximately 99 percent of all fetuses with Turner syndrome result in spontaneous termination during the first trimester.[29] Turner syndrome accounts for about 10 percent of the total number of spontaneous abortions in the United States.[citation needed] The incidence of Turner syndrome in live female births is believed to be around 1 in 2000.[3]

History[]

The syndrome is named after Henry Hubert Turner, an endocrinologist from Illinois, who described it in 1938.[30] In Europe, it is often called Ullrich-Turner syndrome or even Bonnevie-Ullrich-Turner syndrome to acknowledge that earlier cases had also been described by European doctors. The first published report of a female with a 45,X karyotype was in 1959 by Dr. Charles Ford and colleagues in Harwell, Oxfordshire and Guy's Hospital in London.[31] It was found in a 14-year-old girl with signs of Turner syndrome.

See also[]

References[]

  1. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  2. Campbell, Neil. A; Brad Williamson, Robin J. Heyden (2006). Biology : Exploring Life, Boston, Massachusetts: Pearson Prentice Hall.
  3. 3.0 3.1 Donaldson, M D C, E J Gault, K W Tan, D B Dunger (2 2006). Optimising management in Turner syndrome: from infancy to adult transfer. Arch. Dis. Child 91 (6): 513–520.
  4. Sperling, M. (2008). "15" Pediatric endocrinology, 615, Elsevier Health Sciences.
  5. "Turner's Syndrome". Encyclopedia Britannica. Encyclopedia Britannica. Retrieved on 2009-03-24. 
  6. Sybert VP, McCauley E (September 2004). Turner's syndrome. N. Engl. J. Med. 351 (12): 1227–38. [dead link]
  7. Rovet JF (May 1993). The psychoeducational characteristics of children with Turner syndrome. J Learn Disabil 26 (5): 333–41.
  8. includeonly>Wade, Nicholas. "New Clues to Sex Anomalies in How Y Chromosomes Are Copied", The New York Times, 2009-09-15. Retrieved on 2010-05-26.
  9. W H Price, J F Clayton, S Collyer, R De Mey, AND J Wilson (1986). Mortality ratios, life expectancy, and causes of death in patients with Turner's syndrome. Journal of Epidemiology and Community Health 40 (2): 97–102.
  10. 10.0 10.1 10.2 10.3 10.4 10.5 Mazzanti L, Cacciari E (Nov 1998). Congenital heart disease in patients with Turner's syndrome. Italian Study Group for Turner Syndrome (ISGTS). J. Pediatr. 133 (5): 688–92.
  11. 11.0 11.1 Gøtzsche CO, Krag-Olsen B, Nielsen J, Sørensen KE, Kristensen BO (Nov 1994). Prevalence of cardiovascular malformations and association with karyotypes in Turner's syndrome. Arch Dis Child. 71 (5): 433–6.
  12. eMedicine ped/2486
  13. 13.0 13.1 13.2 13.3 13.4 13.5 Elsheikh M, Dunger DB, Conway GS, Wass JA (Feb 2002). Turner's syndrome in adulthood. Endocr. Rev. 23 (1): 120–40.
  14. Prandstraller D, Mazzanti L, Picchio FM, et al. (1999). Turner's syndrome: cardiologic profile according to the different chromosomal patterns and long-term clinical follow-Up of 136 nonpreselected patients. Pediatr Cardiol 20 (2): 108–12.
  15. 15.0 15.1 15.2 15.3 Lin AE, Lippe B, Rosenfeld RG (Jul 1998). Further delineation of aortic dilation, dissection, and rupture in patients with Turner syndrome. Pediatrics 102 (1): e12.
  16. Allen DB, Hendricks SA, Levy JM (Aug 1986). Aortic dilation in Turner syndrome. J Pediatr. 109 (2): 302–5.
  17. Dawson-Falk KL, Wright AM, Bakker B, Pitlick PT, Wilson DM, Rosenfeld RG (Aug 1992). Cardiovascular evaluation in Turner syndrome: utility of MR imaging. Australas Radiol 36 (3): 204–9.
  18. Sybert VP (Jan 1998). Cardiovascular malformations and complications in Turner syndrome. Pediatrics 101 (1): E11.
  19. Concha Ruiz M (2006). Surgical treatment of the aortic root dilatation. An R Acad Nac Med (Madr) 123 (3): 557–68; discussion 569–71.
  20. Berkovitz G, Stamberg J, Plotnick LP, Lanes R (Jun 1983). Turner syndrome patients with a ring X chromosome. Clin Genet. 23 (6): 447–53.
  21. Kaneko N, Kawagoe S, Hiroi M (1990). Turner's syndrome--review of the literature with reference to a successful pregnancy outcome. Gynecol Obstet Invest. 29 (2): 81–7.
  22. Livadas S, Xekouki P, Kafiri G, Voutetakis A, Maniati-Christidi M, Dacou-Voutetakis C (2005). Spontaneous pregnancy and birth of a normal female from a woman with Turner syndrome and elevated gonadotropins.. Fertility and Sterility. 83 (3): 769–72.
  23. Nielsen J, Sillesen I, Hansen KB (1979). Fertility in women with Turner's syndrome. Case report and review of literature. British journal of obstetrics and gynaecology 86 (11): 833–5.
  24. Hovatta O (1999). Pregnancies in women with Turner's syndrome. Ann Med. 31 (2): 106–10.
  25. 25.0 25.1 25.2 25.3 Turner Syndrome Society of the United States. FAQ 6. What can be done?. URL accessed on 2007-05-11.
  26. Bolar K, Hoffman AR, Maneatis T, Lippe B (2008). Long-term safety of recombinant human growth hormone in Turner syndrome. J. Clin. Endocrinol. Metab. 93 (2): 344–51.
  27. Davenport ML, Crowe BJ, Travers SH, et al. (2007). Growth hormone treatment of early growth failure in toddlers with Turner syndrome: a randomized, controlled, multicenter trial. J Clin Endocrinol Metab. 92 (9): 3406–16.
  28. (2008)Uterine Development in Turner Syndrome. GGH Journal 24 (1).
  29. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613558/
  30. Turner HH (1938). A syndrome of infantilism, congenital webbed neck, and cubitus valgus. Endocrinology 23: 566–74.
  31. Ford CE, Jones KW, Polani PE, de Almeida JC, Briggs JH (1959). A sex-chromosome anomaly in a case of gonadal dysgenesis (Turner's syndrome). The Lancet 273 (7075): 711–3.

Further reading[]

External links[]

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