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Triangular part of inferior frontal gyrus

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Brain: Triangular part of inferior frontal gyrus
Gray726
Lateral surface of left cerebral hemisphere, viewed from the side. (Pars triangularis visible near bottom left).
Inferior frontal gyrus
Inferior frontal gyrus. Pars triangularis is not labeled, but is at bottom of region.
Latin pars triangularis gyri frontalis inferioris
Gray's subject #
Part of Inferior frontal gyrus, Broca's area
Components
Artery middle cerebral
Vein
BrainInfo/UW hier-68
MeSH [1]

Pars triangularis is a region of the human cortex, located in the inferior frontal gyrus of the frontal lobe in the corresponding Brodmann area 45. The inferior frontal sulcus forms the superior boundary, the anterior horizontal ramus provides its inferior boundary, and the caudal boundary is made by the anterior ascending ramus (ascending branch of lateral sulcus). The pars triangularis contributes to propositional language comprehension, as in the dominant cortical hemisphere it contributes to the Broca's area. Lesions of the Pars triangularis, lead to the characteristic findings of Broca's aphasia in individuals who are left hemispheric dominant. The is also extensive research on role of Pars triangularis and cortical functions such as language.

Research FindingsEdit

Asymmetry and language dominance Edit

Opercular part of the IFG animation small

Opercular part of the inferior frontal gyrus. Shown in red.

A strong correlation has been found between speech-language and the anatomically asymmetric pt. Foundas, et al. showed that language function can be localized to one region of the brain, as Broca had done before them, but they also supported the idea that one side of the brain is more involved with language than the other. The human brain has two hemispheres, and each one looks similar to the other; that is, it looks like one hemisphere is a mirror image of the other. This is not actually the way it works. Foundas, et al. found that the part of Broca's area we call pars triangularis is actually bigger than the same region in the right side of the brain. Interestingly, this "leftward asymmetry" corresponded both in form and function. This means that the part of the brain that is active during language processing is bigger. In almost all the test subjects, this was the left side. In fact, the only subject tested that had right-hemispheric language dominance was found to have a rightward asymmetry of the pt.[1]

Magnetic Resonance Imaging FindingsEdit

Certain other researchers, however have found no volumetric asymmetries in the pars triangularis. They have challenged previous findings that pars triangularis asymmetry exists and have suggested that inconsistencies in previous findings may be due to great variability in inter-individual pars triangularis morphology. That is, these regions tend to vary in size and shape much more than other areas of the brain, such as deep cortical nuclei. Furthermore, while these researcher found statistically significant asymmetries in the pars opercularis and the planum temporale, they found no correlations between asymmetries of these brain regions with that of the pars triangularis.[2]

Connections in inferior frontal gyrus Edit

At least one study demonstrated a high degree of connectivity between the three subregions of the IFG. By stimulating one region of the IFG and measuring the response in distinct regions, these researchers were able to demonstrate the existence of numerous pathways between pars triangularis and pars opercularis. Also, stimulation of one region of the pars triangularis elicited a response in distinct regions of the pars triangularis illustrating the presence of networks within the subgyral region. [3]

Additionally, The pars triangularis was implicated in semantic processing of language. By measuring the response of the brain by electroencephalography as it responded to different sentence types (those with or without semantic errors), Maess et al. demonstrated a time-lag in the comprehension of erroneous sentences. To understand this one would only need to imagine a person being told something they did not understand. They would pause and take a moment to process the information. Furthermore, these researchers demonstrated a characteristic processing pattern called an “N400”, which refers to a negativity that appears in the pars triangularis about 400 ms after the syntactic mismatch is presented.[4] However, the pars triangularis is likely to be only part of the network generating the N400 response in EEG since the magnetic counter part N400m measured using MEG has been consistently localized to the superior temporal cortex.[5]

Prefrontal cortex & the Cognitive Control of Memory Edit

Pars triangularis has been shown to have a role in cognitive control of memory. There are more ways than one to remember something. When a person remembers, (s)he retrieves information from storage in a memory center of the brain. This information may be the muscle contraction sequence for shoe-tying, the face of a loved one, or anything in between. When someone remembers something automatically, without concentrating on it and without trying, it’s called “bottom-up” processing. But sometimes, people really have to struggle to remember something. Imagine a student taking a test and staring at the one question they haven’t answered thinking to themselves, “Come ON! I know this!” That student is concentrating their attention on retrieving the memory. The student is exhibiting cognitive control over their memory. This type of processing is directed, in part, by the ventrolateral prefrontal cortex (VLPFC). Pars triangularis is found in this region. [6]

When reading aloud, people must decode written language to decipher its pronunciation. This processing takes place in Broca’s area. The reader might use previous knowledge of a word in order to correctly vocalize it, or the reader might use knowledge of systematic letter combinations, which represent corresponding phonemes. Scientists can learn about what the brain is doing while people process language by looking at what it does with errors in language. As above, scientists can investigate the extra processing that occurs when people are challenged with a problem. In this case, scientists took advantage of the way pseudo-words and exception words by examining the brain as it interprets these problematic words. When people process language, they use different parts of Broca’s area for different things. Pars triangularis is involved in a specific type of language processing. Specifically, pars triangularis becomes activated when people read exception words, which are words with atypical spelling-to-sound relationships. For example, “have” is an exception word because it is pronounced with a short, which is contrary to grammatical rules of pronunciation. The “e” at the end of the word should lead to the pronunciation of the long “a” sound, as in “cave” or “rave”. Because we are so familiar with the word “have”, we are able to remember its pronunciation, and we don’t have to think through the rules each time we read it. Pars triangularis helps us do that.[7]

When trying to retrieve information in a top-down fashion, some kind of control mechanism is necessary. Recalling that top-down retrieval depends on conscious control, it is easy to see that there must be some way to exclude irrelevant data from the retrieval. In order to home in on the desired information, some selection must occur. This selection is thought to occur post-retrieval in the mid-VLPFC, which corresponds generally to the location of pt. The theory here is that information is retrieved by certain regions of the left VLPFC, and then it is selected for relevance in another region. This is called the “two part” model of memory retrieval.[8]

Almost every person in the world has learned at least one language. Also, almost everyone that has learned a language has learned it at a young age. Some people are multilingual. Some of these multilingual have learned second or third languages in concert with their first, at a young age, and some have learned other languages in their adulthood. Studies on different subsets of monolinguals and multilinguals have revealed some interesting findings.

By looking at the similarities between the first and second language and what they do to the brain, these researchers found that brain activation looked very different depending on which language the test subjects were processing. They found that pars triangularis activation does not change significantly during processing of these different languages, which is interesting considering the known role of pars triangularis in language.[9]

The question of how the brain processes primary language versus secondary language is not entirely resolved. This paper showed that comprehension of primary and secondary language occurs in generally the same regions of the brain, even if the secondary language was learned late in life.

There is a difference between the processing patterns of primary and secondary languages in processing of passive sentences. These are sentences using some form of the verb “be” with a verb in the past participle form. For example, “He is ruined” is a passive sentence because the verb “ruin” is in the past participle form and used with “is”, which is a form of the verb “be”. This study shows that processing this sentence, late bilinguals used their pars triangularis much more than their counterparts. This result implies certain things about the way language is learned. It could be, for example, that the reason people often have such difficulty learning foreign languages during adulthood is that their brains are trying to code language information in a region of the brain that is not dedicated to understanding language. Perhaps this is the reason native speakers are able to speak so quickly while their late-bilingual counterparts are forced to stutter as they struggle to process grammatical rules. [10]

Cortical Dynamics of Word Recognition Edit

There is a theory that pars triangularis is especially involved in semantic processing of language, as opposed to phonological processing. That is, pars triangularis is thought to be more involved in deciphering the meaning of words rather than trying to decide what the word is based on the sound that goes into the ear. This study got data that supported this theory. Furthermore, these researchers saw evidence for parallel semantic processing, which occurs when the brain multitasks. When their subjects were undergoing experimentation, they were presented with consonant strings, pseudo-words, and words, and the delay between stimulus and brain activity was about the same for phonological and semantic processing, even though the two seemed to occur in slightly different regions. [11]

Another research is "Semantic Encoding and Retrieval in the Left Inferior Prefrontal Cortex: A Functional magnetic resonance imaging Study of Task Difficulty and Process Specificity." These researchers found that pars triangularis (as well as some of its neighbors) increased its activity during semantic encoding, regardless of difficulty of the word being processed. This is consistent with the theory that pars triangularis is involved in semantic processing more than phonological processing. Furthermore, they found that these semantic encoding decisions resulted in less involvement of pars triangularis with repetition of the used words. It may seem intuitive that practice would make the brain better at recognizing the words as they reappeared, but there is something else to be learned from this result, as well. That pars triangularis activity went down with repetition also signifies the movement of the task of recognizing the word from the conscious to the passive. This is called repetition priming, and it occurs independent of intention. This idea, when paired with theories about pt’s involvement in conscious retrieval of memory, serves to illustrate the complexity of the brain and its functions. These results together imply the possibility that similar mechanics are required for encoding and retrieving information. Another point of interest was that decreased pars triangularis activation with repetition did not occur with redundant presentation of nonsemantically processed words. [12]

On Broca, Brain, and Binding: a New Framework Edit

A person is highly interconnected with other regions of the brain, especially those in the left frontal language network. Though its function seems to be distinct from its neighbors, this high degree of connectivity supports the idea that language can be integrated into many of the seemingly unrelated thought processes we have. This is not a difficult idea to imagine. For instance, attempting to remember the name of a brand new acquaintance can be challenging, and it often demands the attention of the person doing the remembering. In this example, a person is trying to comprehend sound as a part of language, place the word they just heard in the category “names”, while associating it also as a tag for the face they just saw, simultaneously committing all of these pieces of data to memory. In this view, it hardly seems far-fetched that the roles of pars triangularis in language processing, semantic comprehension, and conscious control of memory are unrelated. In fact, it would be unlikely for pars triangularis not to have multiple roles in the brain, especially considering its high degree of connectivity, both within the left frontal language center, and to other regions. [13]

Schizophrenia and Broca area Edit

Schizophrenia is a poorly understood disease with complicated symptoms. In an effort to find a cause for this problem, these researchers looked at the brains of schizophrenic patients. It had been shown previously that abnormal gyrification, asymmetry, complexity, and variability occur in patients with schizophrenia. These investigators presented data showing that pt, specifically was highly distorted in schizophrenic patients compared with demographically matched normal subjects. They asserted that Broca’s area is an especially plastic region of the brain in that its morphology can change dramatically from childhood to adulthood. This makes sense when considering the special ability of children to easily learn language, but it also means that the involvement of Broca’s area is limited with respect to memory and recall; children do not seem to be unable to consciously search their memories. Furthermore, investigators took volumetric measurements of the grey and white matter of the brains of their test subjects and compared those measurements to their normal control subjects. They found that schizophrenic patients had dramatically reduced white matter.

As the brain develops, connectivity of different regions changes dramatically. Researchers found that there is a discrepancy in the way white matter and grey matter develop in schizophrenic patients. The tend to have an absence of white matter expansion in schizophrenics.[14]

References Edit

  1. Foundas AL, Leonard CM, Gilmore RL, Fennell EB, Heilman KM (January 1996). Pars triangularis asymmetry and language dominance. Proc Natl Acad Sci U S A 93 (2): 719–722.
  2. Keller SS, Highley JR, Garcia-Finana M, Sluming V, Rezaie R, Roberts N. Sulcal variability, stereological measurement and asymmetry of Broca's area on MRI images. J Anat. Oct, 2007;211(4):534-55.PMID 17727624
  3. Jeremy D.W. Greenlee, Hiroyuki Oya, Hiroto Kawasaki, Igor O. Volkov, Meryl A. Severson III, Matthew A. Howard III, John F. Brugge (2007). Functional connections within the human inferior frontal gyrus. The Journal of Comparative Neurology 503: 550–559.
  4. Burkhard Maess, Christoph S. Herrmann, Anja Hahne, Akinori Nakamura and Angela D. Friederici, Localizing the distributed language network responsible for the N400 measured by MEG during auditory sentence processing, Brain ResearchVolume 1096, Issue 1, 22 June 2006, Pages 163-172. (http://www.sciencedirect.com/science/article/B6SYR-4K5HWMV-2/2/fb4a0a6895ecc30d91968ae79556fc90)
  5. Vartiainen J, Parviainen T, and Salmelin R. 2009. Spatiotemporal convergence of semantic processing in reading and speech perception. Journal of Neuroscience, 29, 9271-9280.
  6. David Badre and Anthony D. Wagner (2007). Left ventrolateral prefrontal cortex and the cognitive control of memory. Neuropsychologia 45 (13): 2883–2901..
  7. Andrea Mechelli, Jennifer T. Crinion, Steven Long, Karl J. Friston, Matthew A. Lambon Ralph, Karalyn Patterson, James L. McClelland, and Cathy J. Price. Dissociating Reading Processes on the Basis of Neuronal Interactions. Journal of Cognitive Neuroscience 17:11:1753-1765
  8. D. Badre, R. Poldrack, E. Pare-Blagoev, R. Insler, and A. Wagner. Dissociable Controlled Retrieval and Generalized Selection Mechanisms in Ventrolateral Prefrontal Cortex. Neuron 2005. 47:907-918
  9. H. Jeong, M. Sugiura, Y. Sassa, T. Haji, N. Usui, M. Taira, K. Horie, S. Sato, R. Kawashima. Effect of syntactic similarity on cortical activation during second language processing: A comparison of English and Japanese among native Korean trilinguals. Human Brain Mapping Jun, 2006. 28:194-204
  10. S. okoyama, H. Okamoto, T. Miyamoto, K. Yoshimoto, J. Kim, K. Iwata, H. Jeong, S. Uchida, N. Ikuta, Y. Sassa, W. Nakamura, K. Horie, S. Sato, and R. Kawashima. Cortical activation in the processing of passive sentences in L1 and L2: An Functional magnetic resonance imaging study. NeuroImage April, 2006. 30:570-579
  11. N. Mainy, J. Jung, M. Baciu, P. Kahane, B. Schoendorff, L. Minotti, D. Hoffmann, O. Bertrand, J. Lachaux. Cortical dynamics of word recognition. Human Brain Mapping Aug 2007. ISSN:1097-0193
  12. J. Demb, J. Desmond, A. Wagner, C. Vaidya, G. Glover, and J. Gabrieli. Cortex: A Functional magnetic resonance imaging Study of Task Difficulty and Process Specificity. The Journal of Neuroscience Sep 1995 15: 5870-5878
  13. P. Hagoort. On Broca, brain, and binding: a new framework. Trends in Cgnitive Sciences. Sep, 2005. 9:416-423
  14. J. Wisco, G. Kuperberg, D. Manoach, B. Quinn, E. Busa, B. Fishl, S. Heckers, and A. Sorensen. Abnormal cortical folding patterns within Broca’s area in schizophrenia: Evidence from structural MRI. Aug, 2007. 94: 317, 327
Telencephalon (cerebrum, cerebral cortex, cerebral hemispheres) - edit

primary sulci/fissures: medial longitudinal, lateral, central, parietoöccipital, calcarine, cingulate

frontal lobe: precentral gyrus (primary motor cortex, 4), precentral sulcus, superior frontal gyrus (6, 8), middle frontal gyrus (46), inferior frontal gyrus (Broca's area, 44-pars opercularis, 45-pars triangularis), prefrontal cortex (orbitofrontal cortex, 9, 10, 11, 12, 47)

parietal lobe: postcentral sulcus, postcentral gyrus (1, 2, 3, 43), superior parietal lobule (5), inferior parietal lobule (39-angular gyrus, 40), precuneus (7), intraparietal sulcus

occipital lobe: primary visual cortex (17), cuneus, lingual gyrus, 18, 19 (18 and 19 span whole lobe)

temporal lobe: transverse temporal gyrus (41-42-primary auditory cortex), superior temporal gyrus (38, 22-Wernicke's area), middle temporal gyrus (21), inferior temporal gyrus (20), fusiform gyrus (36, 37)

limbic lobe/fornicate gyrus: cingulate cortex/cingulate gyrus, anterior cingulate (24, 32, 33), posterior cingulate (23, 31),
isthmus (26, 29, 30), parahippocampal gyrus (piriform cortex, 25, 27, 35), entorhinal cortex (28, 34)

subcortical/insular cortex: rhinencephalon, olfactory bulb, corpus callosum, lateral ventricles, septum pellucidum, ependyma, internal capsule, corona radiata, external capsule

hippocampal formation: dentate gyrus, hippocampus, subiculum

basal ganglia: striatum (caudate nucleus, putamen), lentiform nucleus (putamen, globus pallidus), claustrum, extreme capsule, amygdala, nucleus accumbens

Some categorizations are approximations, and some Brodmann areas span gyri.

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