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Individual differences |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |
Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
The phrase Transient receptor potential or TRP is appended to at least three classes of ion channels which mediate the response of a cell to external stimuli (electrical charge, substances, and forces) by increasing or decreasing its selective permeability to particular ions. The effect of this change is to modify the potential difference between inside and outside of the cell. Hence "receptor," for sensitivity to the environment, and "potential" for this difference.
They are encoded by at least 21 channel subunit genes and divided in three subunits:
- TRPC (canonical): TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPC7
- TRPV (vanilloid): TRPV1, TRPV2, TRPV3, TRPV4, TRPV5, TRPV6
- TRPM (melastatin): TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8
TRPV5 and TRPV6 are calcium entry channels responsible for calcium absorption in kidney and intestine. They were originally named ECaC  and CAT1  and expression is regulated by the vitamin D endocrine system through the active metabolite calcitriol.
TRPM5 is involved in the sensory transduction pathway of taste cells.
TRPM6 is a magnesium entry channel in epithelial tissues mediating magensium reabsorption in the kidney and absorption in the intestine 
- ↑ TRPV3 is a temperature-sensitive vanilloid receptor-like protein G. D. Smith, M. J. Gunthorpe, R. E. Kelsell, P. D. Hayes, P. Reilly, P. Facer, J. E. Wright, J. C. Jerman, J.-P. Walhin, L. Ooi, J. Egerton, K. J. Charles, D. Smart, A. D. Nature 186 418 2002 abstract
- ↑ Molecular identification of the apical Ca2+ channel in 1, 25-dihydroxyvitamin D3-responsive epithelia Hoenderop JG, van der Kemp AW, Hartog A, van de Graaf SF, van Os CH, Willems PH, Bindels RJ. J Biol Chem 1999;274:8375-8. abstract
- ↑ Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. Peng JB, Chen XZ, Berger UV, Vassilev PM, Tsukaguchi H, Brown EM, Hediger MA. J Biol Chem 1999;274:22739-46. abstract
- ↑ Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Schlingmann KP, Weber S, Peters M, Niemann Nejsum L, Vitzthum H, Klingel K, Kratz M, Haddad E, Ristoff E, Dinour D, Syrrou M, Nielsen S, Sassen M, Waldegger S, Seyberth HW, Konrad M. Nat Genet 2002;31:166-70. abstract
- ↑ Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 Sven-Eric Jordt, Diana M. Bautista, Huai-hu Chuang, David D. McKemy, Peter M. Zygmunt, Edward D. Högestätt, Ian D. Meng, David Julius Nature 260 427 2004 abstract
- ↑ Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay H-J Behrendt, T Germann, C Gillen, H Hatt, R Jostock British Journal of Pharmacology 737 141 2004 abstract
Membrane transport protein: ion channels
|Ca||Voltage-dependent calcium channel (L-type/CACNA1C, N-type, P-type, Q-type, R-type, T-type) - Inositol triphosphate receptor - Ryanodine receptor - Cation channels of sperm|
|Na: Sodium channel||Nav1.4 - Nav1.5 - Nav1.7 - Epithelial sodium channel|
|K: Potassium channel||Voltage-gated (KvLQT1, KvLQT2, KvLQT3, HERG, Shaker gene, KCNE1) - Calcium-activated (BK channel, SK channel) - Inward-rectifier (ROMK, KCNJ2) - Tandem pore domain|
|Cl: Chloride channel||Cystic fibrosis transmembrane conductance regulator|
|Porin||Aquaporin (1, 2, 3, 4)|
|Transient receptor potential||TRPA - TRPC (TRPC6) - TRPM (TRPM6) - TRPML (Mucolipin-1) - TRPP - TRPV (TRPV1, TRPV6)|
|Other/general||Gap junction - Stretch-activated ion channel - Ligand-gated ion channel - Voltage-gated ion channel - Cyclic nucleotide-gated ion channel - Two-pore channel|
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