Transferases

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In biochemistry, a transferase is an enzyme that catalyzes the transfer of a functional group (e.g. a methyl or phosphate group) from one molecule (called the donor) to another (called the acceptor). For example, an enzyme that catalyzed this reaction would be a transferase:

A–X + B → A + B–X

In this example, A would be the donor, and B would be the acceptor. The donor is often a coenzyme.

[edit] Nomenclature

Proper names of transferases are formed as "donor:acceptor grouptransferase." However, other names are much more common. The common names of transferases are often formed as "acceptor grouptransferase" or "donor grouptransferase." For example, a DNA methyltransferase is a transferase that catalyzes the transfer of a methyl group to a DNA acceptor.

[edit] Classification

Transferases are classified as EC 2 in the EC number classification. Transferases can be further classified into nine subclasses:

• EC 2.1 includes enzymes that transfer one-carbon groups (methyltransferase)
• EC 2.2 includes enzymes that transfer aldehyde or ketone groups
• EC 2.3 includes acyltransferases
• EC 2.4 includes glycosyltransferases
• EC 2.5 includes enzymes that transfer alkyl or aryl groups, other than methyl groups
• EC 2.6 includes enzymes that transfer nitrogenous groups (transaminase)
• EC 2.7 includes enzymes that transfer phosphorus-containing groups (phosphotransferase, including polymerase and kinase)
• EC 2.8 includes enzymes that transfer sulfur-containing groups (sulfurtransferase and sulfotransferase)
• EC 2.9 includes enzymes that transfer selenium-containing groups

[edit] See also

• Transaminases

[edit] References

• EC 2 Introduction from the Department of Chemistry at Queen Mary, University of London

Enzyme catalysis - Enzyme inhibitor - Enzyme kinetics - Lineweaver-Burk plot - Michaelis-Menten kinetics - List of enzymes

1. REDIRECT Template:One carbon transferases

Template:Aldehyde-ketone transferases

Template:Alkyl and aryl transferases Template:Transaminases Template:Phosphotransferases Template:Sulfur-containing group transferases

This page uses content from the English-language version of Wikipedia. The original article was at Transferase. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.