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Trans-splicing

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Trans-splicing is a special form of RNA processing in eukaryotes where exons from two different primary RNA transcripts are joined end to end and ligated.

In contrast "normal" (cis-)splicing processes a single molecule. That is, trans-splicing results in an RNA transcript that came from multiple RNA polymerases on the genome. This phenomenon can be exploited for molecular therapy to address mutated gene products.[1]

Trans-splicing can be the mechanism behind certain oncogenic fusion transcripts.[2][3]


References Edit

  1. (2009). Trans-splicing as a novel method to rapidly produce antibody fusion proteins. Biochemical and biophysical research communications 384 (3): 316–21.
  2. Li et al. (2008). A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells. Science 321 (5894): 1357–61.
  3. Rickman et al. (2009). SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer. Cancer Res. 69 (7): 2734–8.
  • Dixon RJ, Eperon IC, Samani NJ (2007). Complementary intron sequence motifs associated with human exon repetition: a role for intragenic, inter-transcript interactions in gene expression. Bioinformatics 23 (2): 150–5.
  • Yang Y, Walsh CE (2005). Spliceosome-mediated RNA trans-splicing. Mol. Ther. 12 (6): 1006–12.
  • Coady TH, Shababi M, Tullis GE, Lorson CL (2007). Restoration of SMN Function: Delivery of a Trans-splicing RNA Re-directs SMN2 Pre-mRNA Splicing. Molecular Therapy 15 (8): 1471–8.
  • Wally V, Murauer EM, Bauer JW (2012). Spliceosome-mediated trans-splicing: the therapeutic cut and paste.. J Invest Dermatol. 132 (8): 1959-66.


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