Wikia

Psychology Wiki

Changes: Trans-splicing

Edit

Back to page

(Created page with "{{BioPsy}} '''''Trans''-splicing''' is a special form of RNA processing in eukaryotes where exons from two different primary RNA transcripts are join...")
 
 
Line 6: Line 6:
 
Trans-splicing can be the mechanism behind certain oncogenic [[fusion transcript]]s.<ref>{{cite journal | year = 2008 | title = A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells | pmid = 18772439 | author = Li ''et al.'' | postscript = <!--None--> | doi=10.1126/science.1156725 | volume=321 | issue=5894 | journal=Science | pages=1357–61 | last2 = Wang | first2 = J. | last3 = Mor | first3 = G. | last4 = Sklar | first4 = J.}}</ref><ref>{{cite journal | year = 2009 | title = SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer | pmid = 19293179 | author = Rickman ''et al.'' | postscript = <!--None--> | doi=10.1158/0008-5472.CAN-08-4926 | volume=69 | issue=7 | journal=Cancer Res. | pages=2734–8 | last2 = Pflueger | first2 = D. | last3 = Moss | first3 = B. | last4 = Vandoren | first4 = V. E. | last5 = Chen | first5 = C. X. | last6 = De La Taille | first6 = A. | last7 = Kuefer | first7 = R. | last8 = Tewari | first8 = A. K. | last9 = Setlur | first9 = S. R.}}</ref>
 
Trans-splicing can be the mechanism behind certain oncogenic [[fusion transcript]]s.<ref>{{cite journal | year = 2008 | title = A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells | pmid = 18772439 | author = Li ''et al.'' | postscript = <!--None--> | doi=10.1126/science.1156725 | volume=321 | issue=5894 | journal=Science | pages=1357–61 | last2 = Wang | first2 = J. | last3 = Mor | first3 = G. | last4 = Sklar | first4 = J.}}</ref><ref>{{cite journal | year = 2009 | title = SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer | pmid = 19293179 | author = Rickman ''et al.'' | postscript = <!--None--> | doi=10.1158/0008-5472.CAN-08-4926 | volume=69 | issue=7 | journal=Cancer Res. | pages=2734–8 | last2 = Pflueger | first2 = D. | last3 = Moss | first3 = B. | last4 = Vandoren | first4 = V. E. | last5 = Chen | first5 = C. X. | last6 = De La Taille | first6 = A. | last7 = Kuefer | first7 = R. | last8 = Tewari | first8 = A. K. | last9 = Setlur | first9 = S. R.}}</ref>
   
Trans-splicing is used by certain microbial organisms, notably protozoa of the [[Kinetoplastid|Kinetoplastae class]] to produce variable surface antigens and change from one life stage to another.
 
   
 
== References ==
 
== References ==

Latest revision as of 22:17, October 28, 2013

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


Trans-splicing is a special form of RNA processing in eukaryotes where exons from two different primary RNA transcripts are joined end to end and ligated.

In contrast "normal" (cis-)splicing processes a single molecule. That is, trans-splicing results in an RNA transcript that came from multiple RNA polymerases on the genome. This phenomenon can be exploited for molecular therapy to address mutated gene products.[1]

Trans-splicing can be the mechanism behind certain oncogenic fusion transcripts.[2][3]


References Edit

  1. (2009). Trans-splicing as a novel method to rapidly produce antibody fusion proteins. Biochemical and biophysical research communications 384 (3): 316–21.
  2. Li et al. (2008). A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells. Science 321 (5894): 1357–61.
  3. Rickman et al. (2009). SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer. Cancer Res. 69 (7): 2734–8.
  • Dixon RJ, Eperon IC, Samani NJ (2007). Complementary intron sequence motifs associated with human exon repetition: a role for intragenic, inter-transcript interactions in gene expression. Bioinformatics 23 (2): 150–5.
  • Yang Y, Walsh CE (2005). Spliceosome-mediated RNA trans-splicing. Mol. Ther. 12 (6): 1006–12.
  • Coady TH, Shababi M, Tullis GE, Lorson CL (2007). Restoration of SMN Function: Delivery of a Trans-splicing RNA Re-directs SMN2 Pre-mRNA Splicing. Molecular Therapy 15 (8): 1471–8.
  • Wally V, Murauer EM, Bauer JW (2012). Spliceosome-mediated trans-splicing: the therapeutic cut and paste.. J Invest Dermatol. 132 (8): 1959-66.


This page uses Creative Commons Licensed content from Wikipedia (view authors).

Around Wikia's network

Random Wiki