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#redirect[[Thyroid hormone]]
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{{BioPsy}}
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{{Chembox new
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| ImageFile = Thyroxine-2D-skeletal.png
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| ImageSize =
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| ImageFile1 = T4-3D-vdW.png
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| IUPACName =
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| OtherNames =
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| Section1 = {{Chembox Identifiers
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| CASNo = 7488-70-2
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| PubChem = 853
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| SMILES = NC(Cc1cc(I)c(Oc2cc(I)c(O)<br>c(I)c2)c(I)c1)C(O)=O
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| MeSHName = Thyroxine
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}}
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| Section2 = {{Chembox Properties
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| Formula = C<sub>15</sub>H<sub>11</sub>I<sub>4</sub>NO<sub>4</sub>
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| MolarMass = 776.87
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| Appearance =
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| Density =
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| MeltingPt =
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| BoilingPt =
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}}
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| Section3 = {{Chembox Hazards
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| Solubility =
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| MainHazards =
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| FlashPt =
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| Autoignition =
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}}
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'''Thyroxine''', or 3,5,3',5'-tetra­iodothyronine (often abbreviated as '''T<sub>4</sub>'''), a form of [[thyroid hormones]] is the major [[hormone]] secreted by the [[follicular cells]] of the [[thyroid]] gland.
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T<sub>4</sub> is transported in blood, with 99.95% of the secreted T<sub>4</sub> being protein bound, principally to [[thyroxine-binding globulin]] (TBG), and, to a lesser extent, to [[transthyretin]] and [[serum albumin]]. T<sub>4</sub> is involved in controlling the rate of metabolic processes in the body and influencing physical development.
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Note: Thyroxine is a [[prohormone]] and a reservoir for the active thyroid hormone [[triiodothyronine]] (T<sub>3</sub>). T<sub>4</sub> is converted in the tissues by [[deiodinase]]s to T<sub>3</sub>. The "D" isomer is called "Dextrothyroxine"<ref>{{MeshName|Dextrothyroxine}}</ref> and is used as a lipid modifying agent.<ref>{{ATC|C10|AX01}}</ref> The half-life of thyroxine once released into the blood circulatory system is about 1 week.
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The hormone was synthesised in 1927 by British chemists Charles Robert Harington and George Barger.
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==Reactions==
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:[[image:Iodothyronine_deiodinase.png|thumb|400px|left|Transformations]]{{clear}}
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==See also==
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*[[Hypothyroidism]]
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==References==
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<references/>
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{{Hormones}}
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[[Category:Thyroid hormones]]
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[[Category:Iodinated tyrosine derivatives]]
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<!--
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[[ar:ثيروكسين]]
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[[bg:Тироксин]]
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[[cs:Thyroxin]]
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[[da:Thyroxin]]
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[[de:Thyroxin]]
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[[dv:ތައިރޮކްސިން]]
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[[es:Tiroxina]]
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[[et:Türoksiin]]
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[[fi:Tyroksiini]]
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[[fr:Thyroxine]]
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[[he:תירוקסין]]
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[[it:Tiroxina]]
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[[ja:サイロキシン]]
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[[lt:Tiroksinas]]
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[[nl:Thyroxine]]
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[[pl:Tyroksyna]]
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[[pt:Tiroxina]]
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[[sv:Tyroxin]]
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[[tr:Tiroksin]]
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-->

Latest revision as of 23:02, April 17, 2008

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style="background: #F8EABA; text-align: center;" colspan="2" Thyroxine
200px
200px
Identifiers
CAS number 7488-70-2
PubChem 853
MeSH Thyroxine
SMILES NC(Cc1cc(I)c(Oc2cc(I)c(O)
c(I)c2)c(I)c1)C(O)=O
Properties
Molecular formula C15H11I4NO4
Molar mass 776.87
Hazards
style="background: #F8EABA; text-align: center;" colspan="2" Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Thyroxine, or 3,5,3',5'-tetra­iodothyronine (often abbreviated as T4), a form of thyroid hormones is the major hormone secreted by the follicular cells of the thyroid gland.

T4 is transported in blood, with 99.95% of the secreted T4 being protein bound, principally to thyroxine-binding globulin (TBG), and, to a lesser extent, to transthyretin and serum albumin. T4 is involved in controlling the rate of metabolic processes in the body and influencing physical development.

Note: Thyroxine is a prohormone and a reservoir for the active thyroid hormone triiodothyronine (T3). T4 is converted in the tissues by deiodinases to T3. The "D" isomer is called "Dextrothyroxine"[1] and is used as a lipid modifying agent.[2] The half-life of thyroxine once released into the blood circulatory system is about 1 week.

The hormone was synthesised in 1927 by British chemists Charles Robert Harington and George Barger.

ReactionsEdit

File:Iodothyronine deiodinase.png

See alsoEdit

ReferencesEdit

  1. MeSH Dextrothyroxine
  2. .


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Target-derived NGF, BDNF, NT-3

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