| Formula = C<sub>15</sub>H<sub>11</sub>I<sub>4</sub>NO<sub>4</sub>
+
| MolarMass = 776.87
+
| Appearance =
+
| Density =
+
| MeltingPt =
+
| BoilingPt =
+
}}
+
| Section3 = {{Chembox Hazards
+
| Solubility =
+
| MainHazards =
+
| FlashPt =
+
| Autoignition =
+
}}
+
}}
+
'''Thyroxine''', or 3,5,3',5'-tetraiodothyronine (often abbreviated as '''T<sub>4</sub>'''), a form of [[thyroid hormones]] is the major [[hormone]] secreted by the [[follicular cells]] of the [[thyroid]] gland.
+
+
T<sub>4</sub> is transported in blood, with 99.95% of the secreted T<sub>4</sub> being protein bound, principally to [[thyroxine-binding globulin]] (TBG), and, to a lesser extent, to [[transthyretin]] and [[serum albumin]]. T<sub>4</sub> is involved in controlling the rate of metabolic processes in the body and influencing physical development.
+
+
Note: Thyroxine is a [[prohormone]] and a reservoir for the active thyroid hormone [[triiodothyronine]] (T<sub>3</sub>). T<sub>4</sub> is converted in the tissues by [[deiodinase]]s to T<sub>3</sub>. The "D" isomer is called "Dextrothyroxine"<ref>{{MeshName|Dextrothyroxine}}</ref> and is used as a lipid modifying agent.<ref>{{ATC|C10|AX01}}</ref> The half-life of thyroxine once released into the blood circulatory system is about 1 week.
+
+
The hormone was synthesised in 1927 by British chemists Charles Robert Harington and George Barger.
T4 is transported in blood, with 99.95% of the secreted T4 being protein bound, principally to thyroxine-binding globulin (TBG), and, to a lesser extent, to transthyretin and serum albumin. T4 is involved in controlling the rate of metabolic processes in the body and influencing physical development.
Note: Thyroxine is a prohormone and a reservoir for the active thyroid hormone triiodothyronine (T3). T4 is converted in the tissues by deiodinases to T3. The "D" isomer is called "Dextrothyroxine"[1] and is used as a lipid modifying agent.[2] The half-life of thyroxine once released into the blood circulatory system is about 1 week.
The hormone was synthesised in 1927 by British chemists Charles Robert Harington and George Barger.
Edit
