No edit summary |
No edit summary |
||
Line 1: | Line 1: | ||
+ | {{BioPsy}} |
||
− | #redirect[[Thyroid hormone]] |
||
+ | |||
+ | {{Chembox new |
||
+ | | ImageFile = Thyroxine-2D-skeletal.png |
||
+ | | ImageSize = |
||
+ | | ImageFile1 = T4-3D-vdW.png |
||
+ | | IUPACName = |
||
+ | | OtherNames = |
||
+ | | Section1 = {{Chembox Identifiers |
||
+ | | CASNo = 7488-70-2 |
||
+ | | PubChem = 853 |
||
+ | | SMILES = NC(Cc1cc(I)c(Oc2cc(I)c(O)<br>c(I)c2)c(I)c1)C(O)=O |
||
+ | | MeSHName = Thyroxine |
||
+ | }} |
||
+ | | Section2 = {{Chembox Properties |
||
+ | | Formula = C<sub>15</sub>H<sub>11</sub>I<sub>4</sub>NO<sub>4</sub> |
||
+ | | MolarMass = 776.87 |
||
+ | | Appearance = |
||
+ | | Density = |
||
+ | | MeltingPt = |
||
+ | | BoilingPt = |
||
+ | }} |
||
+ | | Section3 = {{Chembox Hazards |
||
+ | | Solubility = |
||
+ | | MainHazards = |
||
+ | | FlashPt = |
||
+ | | Autoignition = |
||
+ | }} |
||
+ | }} |
||
+ | '''Thyroxine''', or 3,5,3',5'-tetraiodothyronine (often abbreviated as '''T<sub>4</sub>'''), a form of [[thyroid hormones]] is the major [[hormone]] secreted by the [[follicular cells]] of the [[thyroid]] gland. |
||
+ | |||
+ | T<sub>4</sub> is transported in blood, with 99.95% of the secreted T<sub>4</sub> being protein bound, principally to [[thyroxine-binding globulin]] (TBG), and, to a lesser extent, to [[transthyretin]] and [[serum albumin]]. T<sub>4</sub> is involved in controlling the rate of metabolic processes in the body and influencing physical development. |
||
+ | |||
+ | Note: Thyroxine is a [[prohormone]] and a reservoir for the active thyroid hormone [[triiodothyronine]] (T<sub>3</sub>). T<sub>4</sub> is converted in the tissues by [[deiodinase]]s to T<sub>3</sub>. The "D" isomer is called "Dextrothyroxine"<ref>{{MeshName|Dextrothyroxine}}</ref> and is used as a lipid modifying agent.<ref>{{ATC|C10|AX01}}</ref> The half-life of thyroxine once released into the blood circulatory system is about 1 week. |
||
+ | |||
+ | The hormone was synthesised in 1927 by British chemists Charles Robert Harington and George Barger. |
||
+ | |||
+ | ==Reactions== |
||
+ | :[[image:Iodothyronine_deiodinase.png|thumb|400px|left|Transformations]]{{clear}} |
||
+ | |||
+ | ==See also== |
||
+ | *[[Hypothyroidism]] |
||
+ | |||
+ | ==References== |
||
+ | <references/> |
||
+ | |||
+ | {{Hormones}} |
||
+ | |||
+ | [[Category:Thyroid hormones]] |
||
+ | [[Category:Iodinated tyrosine derivatives]] |
||
+ | |||
+ | <!-- |
||
+ | [[ar:ثيروكسين]] |
||
+ | [[bg:Тироксин]] |
||
+ | [[cs:Thyroxin]] |
||
+ | [[da:Thyroxin]] |
||
+ | [[de:Thyroxin]] |
||
+ | [[dv:ތައިރޮކްސިން]] |
||
+ | [[es:Tiroxina]] |
||
+ | [[et:Türoksiin]] |
||
+ | [[fi:Tyroksiini]] |
||
+ | [[fr:Thyroxine]] |
||
+ | [[he:תירוקסין]] |
||
+ | [[it:Tiroxina]] |
||
+ | [[ja:サイロキシン]] |
||
+ | [[lt:Tiroksinas]] |
||
+ | [[nl:Thyroxine]] |
||
+ | [[pl:Tyroksyna]] |
||
+ | [[pt:Tiroxina]] |
||
+ | [[sv:Tyroxin]] |
||
+ | [[tr:Tiroksin]] |
||
+ | --> |
Latest revision as of 23:02, 17 April 2008
Assessment |
Biopsychology |
Comparative |
Cognitive |
Developmental |
Language |
Individual differences |
Personality |
Philosophy |
Social |
Methods |
Statistics |
Clinical |
Educational |
Industrial |
Professional items |
World psychology |
Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
style="background: #F8EABA; text-align: center;" colspan="2" | Thyroxine |
---|---|
File:Thyroxine-2D-skeletal.png | |
File:T4-3D-vdW.png | |
Identifiers | |
CAS number | 7488-70-2 |
PubChem | 853 |
MeSH | Thyroxine |
SMILES | NC(Cc1cc(I)c(Oc2cc(I)c(O) c(I)c2)c(I)c1)C(O)=O |
Properties | |
Molecular formula | C15H11I4NO4 |
Molar mass | 776.87 |
Hazards | |
style="background: #F8EABA; text-align: center;" colspan="2" | Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
Thyroxine, or 3,5,3',5'-tetraiodothyronine (often abbreviated as T4), a form of thyroid hormones is the major hormone secreted by the follicular cells of the thyroid gland.
T4 is transported in blood, with 99.95% of the secreted T4 being protein bound, principally to thyroxine-binding globulin (TBG), and, to a lesser extent, to transthyretin and serum albumin. T4 is involved in controlling the rate of metabolic processes in the body and influencing physical development.
Note: Thyroxine is a prohormone and a reservoir for the active thyroid hormone triiodothyronine (T3). T4 is converted in the tissues by deiodinases to T3. The "D" isomer is called "Dextrothyroxine"[1] and is used as a lipid modifying agent.[2] The half-life of thyroxine once released into the blood circulatory system is about 1 week.
The hormone was synthesised in 1927 by British chemists Charles Robert Harington and George Barger.
Reactions
See also
References
|}
Target-derived NGF, BDNF, NT-3
|}