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Thyroxine

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style="background: #F8EABA; text-align: center;" colspan="2" Thyroxine
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Identifiers
CAS number 7488-70-2
PubChem 853
MeSH Thyroxine
SMILES NC(Cc1cc(I)c(Oc2cc(I)c(O)
c(I)c2)c(I)c1)C(O)=O
Properties
Molecular formula C15H11I4NO4
Molar mass 776.87
Hazards
style="background: #F8EABA; text-align: center;" colspan="2" Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Thyroxine, or 3,5,3',5'-tetra­iodothyronine (often abbreviated as T4), a form of thyroid hormones is the major hormone secreted by the follicular cells of the thyroid gland.

T4 is transported in blood, with 99.95% of the secreted T4 being protein bound, principally to thyroxine-binding globulin (TBG), and, to a lesser extent, to transthyretin and serum albumin. T4 is involved in controlling the rate of metabolic processes in the body and influencing physical development.

Note: Thyroxine is a prohormone and a reservoir for the active thyroid hormone triiodothyronine (T3). T4 is converted in the tissues by deiodinases to T3. The "D" isomer is called "Dextrothyroxine"[1] and is used as a lipid modifying agent.[2] The half-life of thyroxine once released into the blood circulatory system is about 1 week.

The hormone was synthesised in 1927 by British chemists Charles Robert Harington and George Barger.

ReactionsEdit

File:Iodothyronine deiodinase.png

See alsoEdit

ReferencesEdit

  1. MeSH Dextrothyroxine
  2. .


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Target-derived NGF, BDNF, NT-3

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