Fandom

Psychology Wiki

Thyrotropin-releasing hormone receptor

34,203pages on
this wiki
Add New Page
Talk0 Share


Thyrotropin-releasing hormone receptor
Identifiers
Symbol(s) TRHR; MGC141920
External IDs OMIM: 188545 MGI98824 Homologene20707
RNA expression pattern

250px

More reference expression data

Orthologs
Human Mouse Entrez 7201 22045 Ensembl ENSG00000174417 ENSMUSG00000038760 Uniprot P34981 Q32MS1 Refseq NM_003301 (mRNA)
NP_003292 (protein)
NM_013696 (mRNA)
NP_038724 (protein)
Location Chr 8: 110.17 - 110.2 Mb Chr 15: 44.03 - 44.06 Mb
Pubmed search [1] [2]

The thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds the tripeptide thyrotropin releasing hormone.[1][2] The TRHR are found in the brain and when bound by TRH result act through phospholipase C to increase intracellular inositol triphosphate.

References Edit

  1. Yamada M, Monden T, Konaka S, Mori M (1993). Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8. Somat. Cell Mol. Genet. 19 (6): 577–80.
  2. Gershengorn MC (1993). Thyrotropin-releasing hormone receptor: cloning and regulation of its expression. Recent Prog. Horm. Res. 48: 341–63.

Further readingEdit


  • Short RE, James LF, Panter KE, et al. (1993). Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep.. J. Anim. Sci. 70 (11): 3498-504.
  • Yamada M, Iwasaki T, Satoh T, et al. (1996). Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly.. Neurosci. Lett. 196 (1-2): 109-12.
  • Hinuma S, Hosoya M, Ogi K, et al. (1994). Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene.. Biochim. Biophys. Acta 1219 (2): 251-9.
  • Morrison N, Duthie SM, Boyd E, et al. (1994). Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization.. Hum. Genet. 93 (6): 716-8.
  • Yamada M, Monden T, Konaka S, Mori M (1994). Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8.. Somat. Cell Mol. Genet. 19 (6): 577-80.
  • Duthie SM, Taylor PL, Anderson L, et al. (1994). Cloning and functional characterisation of the human TRH receptor.. Mol. Cell. Endocrinol. 95 (1-2): R11-5.
  • Matre V, Karlsen HE, Wright MS, et al. (1993). Molecular cloning of a functional human thyrotropin-releasing hormone receptor.. Biochem. Biophys. Res. Commun. 195 (1): 179-85.
  • Yamada M, Monden T, Satoh T, et al. (1993). Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene.. Biochem. Biophys. Res. Commun. 195 (2): 737-45.
  • Iwasaki T, Yamada M, Satoh T, et al. (1996). Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene.. J. Biol. Chem. 271 (36): 22183-8.
  • Cook JV, McGregor A, Lee T, et al. (1996). A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.. Endocrinology 137 (7): 2851-8.
  • Collu R, Tang J, Castagné J, et al. (1997). A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene.. J. Clin. Endocrinol. Metab. 82 (5): 1561-5.
  • Petrou C, Tashjian AH (1999). The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles.. Cell. Signal. 10 (8): 553-9.
  • Matre V, Høvring PI, Orstavik S, et al. (1999). Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor.. J. Neurochem. 72 (1): 40-50.
  • Kroeger KM, Hanyaloglu AC, Seeber RM, et al. (2001). Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer.. J. Biol. Chem. 276 (16): 12736-43.
  • Zhu CC, Cook LB, Hinkle PM (2002). Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.. J. Biol. Chem. 277 (31): 28228-37.
  • Hanyaloglu AC, Seeber RM, Kohout TA, et al. (2003). Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.. J. Biol. Chem. 277 (52): 50422-30.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903.
  • Cook LB, Zhu CC, Hinkle PM (2004). Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.. Mol. Endocrinol. 17 (9): 1777-91.
  • Igarashi-Migitaka J, Yamada S, Hara M, et al. (2004). Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas.. Endocr. J. 50 (4): 459-67.
  • Cook LB, Hinkle PM (2004). Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.. Endocrinology 145 (7): 3095-100.




External linksEdit


This page uses Creative Commons Licensed content from Wikipedia (view authors).

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.

Also on Fandom

Random Wiki