Wikia

Psychology Wiki

Thyrotropin-releasing hormone receptor

Talk0
34,141pages on
this wiki


Thyrotropin-releasing hormone receptor
Identifiers
Symbol(s) TRHR; MGC141920
External IDs OMIM: 188545 MGI98824 Homologene20707
RNA expression pattern

250px

More reference expression data

Orthologs
Human Mouse Entrez 7201 22045 Ensembl ENSG00000174417 ENSMUSG00000038760 Uniprot P34981 Q32MS1 Refseq NM_003301 (mRNA)
NP_003292 (protein)
NM_013696 (mRNA)
NP_038724 (protein)
Location Chr 8: 110.17 - 110.2 Mb Chr 15: 44.03 - 44.06 Mb
Pubmed search [1] [2]

The thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds the tripeptide thyrotropin releasing hormone.[1][2] The TRHR are found in the brain and when bound by TRH result act through phospholipase C to increase intracellular inositol triphosphate.

References Edit

  1. Yamada M, Monden T, Konaka S, Mori M (1993). Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8. Somat. Cell Mol. Genet. 19 (6): 577–80.
  2. Gershengorn MC (1993). Thyrotropin-releasing hormone receptor: cloning and regulation of its expression. Recent Prog. Horm. Res. 48: 341–63.

Further readingEdit


  • Short RE, James LF, Panter KE, et al. (1993). Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep.. J. Anim. Sci. 70 (11): 3498-504.
  • Yamada M, Iwasaki T, Satoh T, et al. (1996). Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly.. Neurosci. Lett. 196 (1-2): 109-12.
  • Hinuma S, Hosoya M, Ogi K, et al. (1994). Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene.. Biochim. Biophys. Acta 1219 (2): 251-9.
  • Morrison N, Duthie SM, Boyd E, et al. (1994). Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization.. Hum. Genet. 93 (6): 716-8.
  • Yamada M, Monden T, Konaka S, Mori M (1994). Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8.. Somat. Cell Mol. Genet. 19 (6): 577-80.
  • Duthie SM, Taylor PL, Anderson L, et al. (1994). Cloning and functional characterisation of the human TRH receptor.. Mol. Cell. Endocrinol. 95 (1-2): R11-5.
  • Matre V, Karlsen HE, Wright MS, et al. (1993). Molecular cloning of a functional human thyrotropin-releasing hormone receptor.. Biochem. Biophys. Res. Commun. 195 (1): 179-85.
  • Yamada M, Monden T, Satoh T, et al. (1993). Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene.. Biochem. Biophys. Res. Commun. 195 (2): 737-45.
  • Iwasaki T, Yamada M, Satoh T, et al. (1996). Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene.. J. Biol. Chem. 271 (36): 22183-8.
  • Cook JV, McGregor A, Lee T, et al. (1996). A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.. Endocrinology 137 (7): 2851-8.
  • Collu R, Tang J, Castagné J, et al. (1997). A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene.. J. Clin. Endocrinol. Metab. 82 (5): 1561-5.
  • Petrou C, Tashjian AH (1999). The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles.. Cell. Signal. 10 (8): 553-9.
  • Matre V, Høvring PI, Orstavik S, et al. (1999). Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor.. J. Neurochem. 72 (1): 40-50.
  • Kroeger KM, Hanyaloglu AC, Seeber RM, et al. (2001). Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer.. J. Biol. Chem. 276 (16): 12736-43.
  • Zhu CC, Cook LB, Hinkle PM (2002). Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.. J. Biol. Chem. 277 (31): 28228-37.
  • Hanyaloglu AC, Seeber RM, Kohout TA, et al. (2003). Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.. J. Biol. Chem. 277 (52): 50422-30.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903.
  • Cook LB, Zhu CC, Hinkle PM (2004). Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.. Mol. Endocrinol. 17 (9): 1777-91.
  • Igarashi-Migitaka J, Yamada S, Hara M, et al. (2004). Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas.. Endocr. J. 50 (4): 459-67.
  • Cook LB, Hinkle PM (2004). Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.. Endocrinology 145 (7): 3095-100.




External linksEdit


This page uses Creative Commons Licensed content from Wikipedia (view authors).

Around Wikia's network

Random Wiki