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{{BioPsy}}
 
{{BioPsy}}
   
'''Thyronamines''' are [[decarboxylation|decarboxylated]] and [[iodine|deiodinated]] [[metabolite]]s of the [[thyroid hormone]]s thyroxine (T4) and 3,5,3'-triiodothyronine (T3).
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{{Chembox new
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| ImageFile = Thyronamine-2D-skeletal.png
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| ImageSize = 300px
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| ImageFile2 = Thyronamine3d.png
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| ImageSize2 = 300px
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| IUPACName =
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| OtherNames =
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| Section1 = {{Chembox Identifiers
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| CASNo = 500-78-7
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| PubChem = 3083601
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| SMILES =
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| MeSHName = thyronamine
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}}
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| Section2 = {{Chembox Properties
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| Formula = C<sub>14</sub>H<sub>15</sub>NO<sub>2</sub>
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| MolarMass = 229.274 g mol<sup>−1</sup>
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| Appearance =
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| Density =
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| MeltingPt =
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| BoilingPt =
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}}
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| Section3 = {{Chembox Hazards
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| Solubility =
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| MainHazards =
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| FlashPt =
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| Autoignition =
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}}
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}}
   
The thyronamine 3-iodothyronamine (T<sub>1</sub>AM) is a natural, high-affinity [[ligand]] for the trace amine-associated [[receptor (biochemistry) | receptor]] TAAR1 (TAR1, TA1), a [[G-protein-coupled receptor]]. In rodents, T<sub>1</sub>AM causes a rapid drop in body temperature when injected.
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'''Thyronamine''' refers both to a molecule, and to derivatives of that molecule: a family of [[decarboxylation|decarboxylated]] and [[iodine|deiodinated]] [[metabolite]]s of the [[thyroid hormone]]s [[thyroxine]] (T4) and [[triiodothyronine|3,5,3'-triiodothyronine]] (T3).
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The group includes:
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* Thyronamine (T0AM)
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* [[3-Iodothyronamine]] (T1AM), which is the most notable one as it is a [[trace amine]] found in the [[nervous system]]. It is a possible candidate for the natural ligand of the [[trace amine-associated receptor]] TAAR1 (TAR1), a [[G protein-coupled receptor]] located in the [[cell membrane]].
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* 3,5-Diiodothyronamine (T2AM)
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* 3,5,3'-Triiodothyronamine (T3AM)
   
 
== See also ==
 
== See also ==
   
* [[Trace amine]]
 
 
* [[Thyroid hormone]]
 
* [[Thyroid hormone]]
   
== References ==
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[[Category:Biogenic amines]]
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[[Category:Iodinated tyrosine derivatives]]
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[[Category:Phenethylamines]]
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[[Category:Phenols]]
   
* Nat. Med. 10(6):638-642 (2004) ''3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone'' PMID 15146179
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<!--
* J. Med. Chem. 49(3):1101-1112 (2006) ''Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues'' PMID 16451074
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[[de:Thyronamine]]
{{enWP|Thyronamine}}
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-->
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{{enWP|Thyroid hormone}}

Latest revision as of 23:36, April 16, 2008

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style="background: #F8EABA; text-align: center;" colspan="2" Thyronamine
300px
300px
Identifiers
CAS number 500-78-7
PubChem 3083601
MeSH thyronamine
Properties
Molecular formula C14H15NO2
Molar mass 229.274 g mol−1
Hazards
style="background: #F8EABA; text-align: center;" colspan="2" Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references


Thyronamine refers both to a molecule, and to derivatives of that molecule: a family of decarboxylated and deiodinated metabolites of the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3).

The group includes:

See also Edit

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