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m (Thrombus moved to Thromboses: Align thesaurus)
 
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[[Image:Blood clot diagram.png|thumb|300px|Blood clot diagram.]]
 
[[Image:Blood clot diagram.png|thumb|300px|Blood clot diagram.]]
A '''thrombus''', or '''blood clot''', is the final product of the [[blood coagulation]] step in [[hemostasis]]. It is achieved via the aggregation of [[platelets]] that form a platelet plug, and the activation of the humoral [[coagulation]] system (i.e. clotting factors). A thrombus is [[physiology|physiologic]] in cases of [[injury]], but [[pathology|pathologic]] in case of [[thrombosis]].
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A '''thrombus''', or '''blood clot''', is the final product of the [[blood coagulation]] step in [[hemostasis]]. It is achieved via the aggregation of [[platelets]] that form a platelet plug, and the activation of the humoral [[coagulation]] system (i.e. clotting factors). A thrombus is normal in cases of [[injury]] (but see also [[thrombosis]]).
   
Specifically, a thrombus is a blood clot in an intact blood vessel. A thrombus in a large blood vessel will decrease blood flow through that vessel. In a small blood vessel, blood flow may be completely cut-off resulting in the death of tissue supplied by that vessel. If a thrombus dislodges and becomes free-floating, it is an [[embolus]].
+
Specifically, a thrombus is a blood clot in an intact blood vessel. A thrombus in a large blood vessel will decrease blood flow through that vessel. In a small blood vessel, blood flow may be completely cut-off resulting in death of tissue supplied by that vessel. If a thrombus dislodges and becomes free-floating, it is an [[Embolism|embolus]].
   
Some of the conditions in which blood clots develop include [[atrial fibrillation]] (a form of [[cardiac arrhythmia]]), heart valve replacement, a recent [[myocardial infarction|heart attack]], extended periods of inactivity (see [[deep venous thrombosis]]), and genetic or disease-related deficiencies in the blood's clotting abilities.
+
Some of the conditions which elevate risk of blood clots developing include [[atrial fibrillation]] (a form of [[cardiac arrhythmia]]), heart valve replacement, a recent [[myocardial infarction|heart attack]], extended periods of inactivity (see [[deep venous thrombosis]]), and genetic or disease-related deficiencies in the blood's clotting abilities.
   
Preventing blood clots reduces the risk of stroke, heart attack and [[pulmonary embolism]]. [[Heparin]] and [[warfarin]] are often used to inhibit the formation and growth of existing blood clots, thereby allowing the body to shrink and dissolve the blood clots through normal methods (see [[anticoagulant]]).
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Blood clot prevention reduces the risk of stroke, heart attack and [[pulmonary embolism]]. [[Heparin]] and [[warfarin]] are often used to inhibit the formation and growth of existing blood clots; they are able to decrease blood coagulation by inhibiting vitamin K epoxide reductase, an enzyme that recycles oxidated vitamin K to its reduced form after it has participated in the carboxylation of several blood coagulation proteins, mainly prothrombin and factor VII.
   
A thrombus differs from a [[haematoma]] by:
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[[Virchow's triad]] describes the conditions necessary for thrombus formation:
*Having high [[haematocrit]]
 
*Being non-laminar
 
*Being soft and friable
 
*Having an absence of circulation
 
 
[[Rudolf Virchow|Virchow's]] [[Virchow's triad|Triad]] describes the conditions necessary for thrombus formation:
 
   
 
# Changes in vessel wall morphology (e.g. trauma, [[atheroma]])
 
# Changes in vessel wall morphology (e.g. trauma, [[atheroma]])
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# Changes in blood composition (e.g. [[leukaemia]], hypercoagulability disorders)
 
# Changes in blood composition (e.g. [[leukaemia]], hypercoagulability disorders)
   
Disseminated intravascular coagulation ([[DIC]]) involves widespread microthrombi formation throughout the majority of the blood vessels. This is due to excessive consumption of coagulation factors and [[fibrinolysis]] using all of the body's available [[platelets]] and clotting factors. The end result is ischaemic necrosis of the affected tissue/organs and spontaneous bleeding due to the lack of clotting factors. Causes are [[septicaemia]], acute [[leukaemia]], [[shock]], snake bites or severe trauma. Treatment involves the use of fresh, frozen plasma to restore the level of clotting factors in the blood.
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[[Disseminated intravascular coagulation]] (DIC) involves widespread microthrombi formation throughout the majority of the blood vessels. This is due to excessive consumption of coagulation factors and [[fibrinolysis]] using all of the body's available [[platelets]] and clotting factors. The end result is ischaemic necrosis of the affected tissue/organs and spontaneous bleeding due to the lack of clotting factors. Causes are [[septicaemia]], acute [[leukaemia]], [[shock (circulatory)|shock]], snake bites or severe trauma. Treatment involves the use of fresh, frozen plasma to restore the level of clotting factors in the blood.
   
== etymology ==
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==See also==
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* [[Embolisms]]
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* [[Coronary thromboses]]
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* [[National Alliance for Thrombosis and Thrombophilia]]
   
The word Thrombus is derived from Greek Thrombos meaning "lump".
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==External links==
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*[http://www.med-help.net/BloodClot.html Treatment and Symptoms of Blood Clots] -- [http://www.med-help.net Med-Help.net], Medical Information Resource, 1999
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*[http://www.natfonline.org/ North American Thrombosis Forum] - NATF is a nonprofit organization dedicated to promoting thrombosis research, prevention and education, public policy, and advocacy outreach.
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*[http://www.stoptheclot.org/learn_more/learn_more.htm The National Alliance for Thrombosis and Thrombophilia] - has extensive stories from patients and family members on living with Thrombosis and Thrombophilia, assembled frequently asked questions and created publications addressing specific blood clot issues.
   
==See also==
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{{Hemodynamics}}
* [[thrombolysis]] ("clot breaking")
 
* [[thrombogenicity]] (the tendency to clot)
 
   
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[[Category:Cardiac disorders]]
 
[[Category:Hematology]]
 
[[Category:Hematology]]
   
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Latest revision as of 08:23, January 21, 2009

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Blood clot diagram

Blood clot diagram.

A thrombus, or blood clot, is the final product of the blood coagulation step in hemostasis. It is achieved via the aggregation of platelets that form a platelet plug, and the activation of the humoral coagulation system (i.e. clotting factors). A thrombus is normal in cases of injury (but see also thrombosis).

Specifically, a thrombus is a blood clot in an intact blood vessel. A thrombus in a large blood vessel will decrease blood flow through that vessel. In a small blood vessel, blood flow may be completely cut-off resulting in death of tissue supplied by that vessel. If a thrombus dislodges and becomes free-floating, it is an embolus.

Some of the conditions which elevate risk of blood clots developing include atrial fibrillation (a form of cardiac arrhythmia), heart valve replacement, a recent heart attack, extended periods of inactivity (see deep venous thrombosis), and genetic or disease-related deficiencies in the blood's clotting abilities.

Blood clot prevention reduces the risk of stroke, heart attack and pulmonary embolism. Heparin and warfarin are often used to inhibit the formation and growth of existing blood clots; they are able to decrease blood coagulation by inhibiting vitamin K epoxide reductase, an enzyme that recycles oxidated vitamin K to its reduced form after it has participated in the carboxylation of several blood coagulation proteins, mainly prothrombin and factor VII.

Virchow's triad describes the conditions necessary for thrombus formation:

  1. Changes in vessel wall morphology (e.g. trauma, atheroma)
  2. Changes in blood flow through the vessel (e.g. valvulitis, aneurysm)
  3. Changes in blood composition (e.g. leukaemia, hypercoagulability disorders)

Disseminated intravascular coagulation (DIC) involves widespread microthrombi formation throughout the majority of the blood vessels. This is due to excessive consumption of coagulation factors and fibrinolysis using all of the body's available platelets and clotting factors. The end result is ischaemic necrosis of the affected tissue/organs and spontaneous bleeding due to the lack of clotting factors. Causes are septicaemia, acute leukaemia, shock, snake bites or severe trauma. Treatment involves the use of fresh, frozen plasma to restore the level of clotting factors in the blood.

See alsoEdit

External linksEdit

Template:Hemodynamics


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