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The role of the amygdala in memory

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The amygdala plays a key role in the modulation of memory consolidation. Following any learning event, the long-term memory for the event is not instantaneously formed. Rather, information regarding the event is slowly put into long-term storage over time, a process referred to as "memory consolidation", until it reaches a relatively permanent state.

During the consolidation period, the memory can be modulated. In particular, it appears that emotional arousal following the learning event influences the strength of the subsequent memory for that event. Greater emotional arousal following a learning event enhances a person's retention of that event. Experiments have shown that administration of stress hormones to a person immediately after the person learns something enhances that person's retention when they are tested two weeks later.

The amygdala, especially the basolateral amygdala, plays a key role in mediating the effects of emotional arousal on the strength of the memory for the event, as shown by many laboratories including that of James McGaugh. These laboratories have trained animals on a variety of learning tasks and found that drugs injected into the amygdala after training affect the animals' subsequent retention of the task. These tasks include basic Pavlovian tasks such as inhibitory avoidance (where a rat learns to associate a mild footshock with a particular compartment of an apparatus) and more complex tasks such as spatial or cued water maze (where a rat learns to swim to a platform to escape the water). If a drug that activates the amygdala is injected into the amygdala, the animal has better memory for the training in the task. If a drug that inactivates the amygdala is injected into it, the animal has impaired memory for the task.

Despite the importance of the amygdala in modulating memory consolidation, however, learning can occur without it, though such learning appears to be impaired.

Evidence from work with humans indicates that the amygdala plays a similar role. Amygdala activity at the time of encoding information correlates with retention for that information. However, this correlation depends on the relative "emotionalness" of the information. More emotionally arousing information increases amygdala activity and that activity correlates with retention.


See alsoEdit

References & BibliographyEdit

Key textsEdit

BooksEdit

PapersEdit

  • Adolphs, R., Cahill, L., Schul, R. and Babinsky, R. (1997). Impaired declarative memory for emotional stimuli following bilateral amygdala damage in humans , Learning and Memory 4 291-300.
  • Cahill, L., Haier, R. J., White, N. S., Fallon, J., Kilpatrick, L., Lawrence, C., Potkin, S. G., and Alkire, M. T. (2000). Sex-related difference in amygdala activity during emotionally influenced memory storage, Neurobiology of Learning and Memory 75 1-9.
  • Cahill, L., Babinsky, R., Markowitsch, H. J. and McGaugh, J. L. (1995). The amygdala and emotional memory , Nature 377 295-6
  • Canli, T., Zhao, Z., Brewer, J., Gabrieli, J. D. and Cahill, L. (2000). Event related activation in the human amygdala associates with later memory for individual emotional experience , Journal of Neuroscience 20.
  • Da Cunha, C., Wolfman, C., Huang, C., Walz, R., Koya, R., Bianchin, M., Medina, J. H. and Izquierdo, I. (1991). Effect of posttraining injections of flumazenil into the amygdala, hippocampus and septum on retention of habituation and of inhibitory avoidance in rats , Brazilian Journal of Medical and Biological Research 24 301-6.
  • Hatfield, T., Spanis, C. and McGaugh, J. L., Response of amygdalar norepinephrine to footshock and GABAergic drugs using in vivo microdialysis and HPLC , Brain Research 835, 340-45.
  • Hamann, S. G., Elt, T., Grafton, S., and Kilts, C., Amygdala activity related to enhanced memory for pleasant and aversive stimuli , Nature Neuroscience 2 (1999), 289-93.
  • Hatfield, T. and McGaugh, J. L. (1999). Norepinephrine infused into the basolateral amygdala posttraining enhances retention in a spatial water maze task , Neurobiology of Learning and Memory 71, 232-9
  • Ferry, B. and McGaugh, J. L. (1999). Clenbuterol administration into the basolateral amygdala post-training enhances retention in an inhibitory avoidance task , Neurobiology of Learning and Memoir 72, 8-12.
  • Gallagher, M., Kapp, B. S., Pascoe, J. P. and Rapp, P. R., (1981). A neuropharmacology of amygdaloid systems which contribute to learning and memory . In Ben-Air, Y. (ed.), The Amygdaloid Complex, Amsterdam, Elsevier/N. Holland.
  • Ikegaya, Y., Saito, H. and Abe, K. (1995). Requirement of basolateral amygdale neuron activity for the induction of long-term potentiation in the dentate gyrus in vivo , Brain Research 67, 351-4
  • Izquierdo, I., Quillfeldt, J. A., Zanatta, M. S., Quevedo, J, Schaeffer, E., Schmitz, P. K. and Medina J. H. (1997). Sequential role of hippocampus and amygdala, entorhinal cortex and parietal cortex in formation and retrieval of memory for inhibitory avoidance in rats , European Journal of Neuroscience 9, 786-93
  • Keator, D., Wu, J. and McGaugh, J. L. (1996). Amygdala activity at encoding correlated with long-term, free recall of emotional information , Proceedings, National Academy of Sciences. USA 93 8016-21.
  • Lehmann, EL, Treat,D., and Parent, M. B. (2000). Amygdala lesions do not impair shock-probe avoidance retention performance , Behavioral Neuroscience 114, 107-16.
  • Liang, K. C., Juler, R. G. and McGaugh, J. L. (1986). Modulating effects of post-training epinephrine on memory: involvement of the amygdala noradrenergic system , Brain Research 368, 125-33.
  • McIntyre, C. K., Hatfield, T. and McGaugh, J. L., (2002), Amygdala norepinephrine levels after training produce inhibitory avoidance retention performance in rats , European Journal of Neuroscience 16 1223-26.
  • McGaugh, J. L., (2002). The amygdala regulates memory consolidation . In Squire, L. R. and Schacter, D. L. (eds.) Neuropsychology of Memory, 3rd Edition, The Guilford Press, New York.
  • McGaugh, J. L. (2002). Memory consolidation and the amygdala: A systems perspective , Trends in Neurosciences 25, 456-61.
  • McGaugh, J. L., Ferry, B., Vazdarjanova, A. and Roozendaal, B., (2000) Amygdala: Role in modulation of memory storage. In Aggleton, J. P. (ed.), The Amygdala: A Functional Analysis, Oxford University Press, London.
  • Gallagher, M., Kapp, B. S., Pascoe, J. P., and Rapp, P. R., (1981). A neuropharmacology of amygdaloid systems which contribute to learning and memory . In Ben-Air, Y. (ed.), The Amygdaloid Complex, Amsterdam, Elsevier/N. Holland.
  • Mori, E., Ikeda, M., Hirono, N., Kitagaki, H., Imamura, T. and Shimomura, T. (1999). Amygdalar volume and emotional memory in Alzheimer s disease , American Journal of Psychiatry 156, 216-22
  • Packard, M. G, Cahill, L. and McGaugh, J. L. (1994). Amygdala modulation of hippocampal-dependent and caudate nucleus-dependent memory processes , Proceedings, National Academy of Sciences, USA 91, 8477-81
  • Packard, M. G., and Teather, L. (1998). Amygdala modulation of multiple memory systems: Hippocampus and caudate-putamen , Neurobiology of Learning and Memory 69, 163-203.
  • Phelps, E. A. and Anderson, A. K. (1997). Emotional memory: What does the amygdala do? , Current Biology 7, 311-314
  • Quirarte, G. L., *Galvez, R., Roozendaal, B. and McGaugh, J. L. (1998). Norepinephrine release in the amygdala in response to footshock and opioid peptidergic drugs , Brain Research 808, 134-40;
  • Tomaz, C., Dickinson-Anson, H. and McGaugh, J. L. (1992). Basolateral amygdala lesions block diazepam-induced anterograde amnesia in an inhibitory avoidance task , Proceedings, National Academy of Sciences, USA 89, 3615-19.
  • Walker, D L., Ressler, K. J., Lu, K. T. and Davis, M. (2002). Facilitation of conditioned fear extinction by systematic administration or intraamygdala infusions of d-cycloserine as assessed with fear-potentiated startle in rats , Journal of Neuroscience, 22, 2343-51.


Additional materialEdit

BooksEdit

PapersEdit

  • Goddard, G. (1964). Amygdaloid stimulation and learning in the rat , Journal of Comparative and Physiological Psychology 58, 23-30.

External linksEdit


Memory
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Aspects of memory
Childhood amnesia | Cryptomnesia |Cued recall | Eye-witness testimony | Memory and emotion | Forgetting |Forgetting curve | Free recall | Levels-of-processing effect | Memory consolidation |Memory decay | Memory distrust syndrome |Memory inhibition | Memory and smell | Memory for the future | Memory loss | Memory optimization | Memory trace | Mnemonic | Memory biases  | Modality effect | Tip of the tongue | Lethologica | Memory loss |Priming | Primacy effect | Reconstruction | Proactive interference | Prompting | Recency effect | Recall (learning) | Recognition (learning) | Reminiscence | Retention | Retroactive interference | Serial position effect | Serial recall | Source amnesia |
Memory theory
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Mnemonics
Method of loci | Mnemonic room system | Mnemonic dominic system | Mnemonic learning | Mnemonic link system |Mnemonic major system | Mnemonic peg system | [[]] |[[]] |
Neuroanatomy of memory
Amygdala | Hippocampus | prefrontal cortex  | Neurobiology of working memory | Neurophysiology of memory | Rhinal cortex | Synapses |[[]] |
Neurochemistry of memory
Glutamatergic system  | of short term memory | [[]] |[[]] | [[]] | [[]] | [[]] | [[]] |[[]] |
Developmental aspects of memory
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Prominant workers in memory|-
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Philosophy and historical views of memory
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Journals | Learning, Memory, and Cognition |Journal of Memory and Language |Memory |Memory and Cognition | [[]] | [[]] | [[]] |
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