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The thalamic reticular nucleus is part of the ventral thalamus that forms a capsule around the thalamus laterally. It is separated from the thalamus by the external medullary lamina. Reticular cells are GABAergic, and have discoid dendritic arbors in the plane of the nucleus. The thalamic reticular nucleus receives input from the cerebral cortex and dorsal thalamic nuclei. Most input comes from collaterals of fibers passing through the thalamic reticular nucleus. Primary thalamic reticular nucleus efferent fibers project to dorsal thalamic nuclei, but never to the cerebral cortex. This is the only thalamic nucleus that does not project to the cerebral cortex.The function of the thalamic reticular nucleus is not understood, although it has some role in absence seizures, von Krosigk et al., 1993. There is debate over the presence of distinct sectors within the nucleus that each correspond to a different sensory or cognitive modality.

For original connectivity anatomy see Jones 1975; For discussion of mapping and cross modality pathways see Crabtree 2002.

Thalamic Reticular Nucleus is variously abbreviated TRN, RTN, NRT, and RT.

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• Brain Atlas, Brain Maps, Neuroinformatics

v·d·e Human brain: diencephalon (TA A14.1.08, GA 9.807)
Epithalamus	Surface Pineal body · Habenula · Habenular trigone · Habenular commissure Grey matter Pretectal area · Habenular nuclei · Subcommissural organ
Thalamus	Surface Stria medullaris of thalamus · Thalamic reticular nucleus · Taenia thalami Grey matter/ nuclei paired: AN · Ventral (VA/VL, VP/VPM/VPL) · Lateral (LD, LP, Pulvinar) · Metathalamus (MG, LG) midline: MD · Intralaminar (Centromedian) · Midline nuclear group · Interthalamic adhesion White matter Mammillothalamic fasciculus · Pallidothalamic tracts (Ansa lenticularis, Lenticular fasciculus, Thalamic fasciculus) · PCML (Medial lemniscus, Trigeminal lemniscus) · Spinothalamic tract · Lateral lemniscus · Dentatothalamic tract · Acoustic radiation · Optic radiation · Subthalamic fasciculus · Anterior trigeminothalamic tract Medullary laminae
Hypothalamus	Surface Median eminence/Tuber cinereum · Mammillary body · Infundibulum Grey matter Autonomic zones Anterior (parasympathetic/heat loss) · Posterior (sympathetic/heat conservation) Endocrine posterior pituitary: magnocellular/Paraventricular/Supraoptic (oxytocin/vasopressin) other: parvocellular/Arcuate (dopamine/GHRH) · Preoptic (GnRH) · Suprachiasmatic (melatonin) Emotion Lateral (hunger) · Ventromedial (satiety) · Dorsomedial (rage) White matter afferent (SN → Medial forebrain bundle) · efferent (Mammillothalamic fasciculus → AN, Stria terminalis → Amygdala, Dorsal longitudinal fasciculus → SC) Pituitary Posterior is diencephalon, but anterior is glandular
Subthalamus	Subthalamic nucleus · Zona incerta
Ventricular system: Third ventricle	recesses: (Optic recess, Infundibular recess, Suprapineal recess, Pineal recess) Hypothalamic sulcus · Tela chorioidea of third ventricle Subfornical organ Apertures: Interventricular/Monro Posterior commissure

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