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#redirect[[Testis-determining factor]]
'''Testis-determining factor''' ('''TDF''') is a general term for the [[gene]] (or product thereof) that results in [[maleness]] in humans and some other species. TDF can also apply to several genes, depending on the specific sex determination
 
 
Current thinking is that certain genes will cause the chemical reactions that result in the development of [[testes]]. [[Embryo]]s are [[gonad]]ally identical, regardless of genetic sex, until a certain point in development; then the testis-determining factor causes male [[sex organs]] to develop, while lack of this factor will cause the embryo to develop as physically [[female]].
 
 
The TDF factor is encoded by the [[SRY]] [[gene]] located in the [[Y chromosome]]. It is a [[Deoxyribonucleic acid|DNA]] binding protein, that enhances other [[transmission factor]]s, or is a transcription factor itself. Its [[Gene expression|expression]] directly or indirectly causes the development of primary [[sex chord]]s, which will later develop to [[seminiferous tubule]]s. These chords form in the central part of the undifferentiated-yet [[gonad]], turning it into a [[testis]]. The testis then starts secreting [[testosterone]] and the [[Anti-müllerian hormone]].
 
 
Older texts were discussing the role of the [[HY antigen]] in the control of testicular development, but this was later disproven.
 
 
{{med-stub}}
 
[[Category:Genes]]
 
[[Category:Epigenetics]]
 
{{enWP|Testis determining factor}}
 

Latest revision as of 23:50, September 28, 2013

  1. redirectTestis-determining factor

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