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Terbutaline chemical structure
| CAS number |
| ATC code |
| PubChem |
| DrugBank |
|Molecular weight||225.284 g/mol|
|Metabolism||GI tract (oral), liver; CYP450: unknown|
|Elimination half-life||urine 90% (60% unchanged), bile/faeces; Half-life: 3-4h|
|Routes of administration||SQ, Oral, Inhaled|
Terbutaline (trade names Brethine, Bricanyl, or Brethaire) is a β2-adrenergic receptor agonist, used as a fast-acting bronchodilator (often used as a short-term asthma treatment) and as a tocolytic to delay premature labour. The inhaled form of terbutaline starts working within 15 minutes and can last up to 6 hours.
Terbutaline as a treatment for premature labour is an off-label use not approved by the FDA. Studies have suggested that terbutaline is a developmental neurotoxicant and may cause brain damage to the infant.
Maternal - tachycardia, nervousness, tremors, headache and possible pulmonary edema. Fetal - tachycardia and hypoglycemia. Terbutaline is preferred over Ritodrine because it has minimal effects on blood pressure.
Template:Asthma and copd rx
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