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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
Terbutaline chemical structure | |
5-(1-hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol IUPAC name | |
CAS number 23031-25-6 |
ATC code R03AC03 . |
PubChem 5403 |
DrugBank APRD00589 |
Chemical formula | {{{chemical_formula}}} |
Molecular weight | 225.284 g/mol |
Bioavailability | |
Metabolism | GI tract (oral), liver; CYP450: unknown |
Elimination half-life | urine 90% (60% unchanged), bile/faeces; Half-life: 3-4h |
Excretion | {{{excretion}}} |
Pregnancy category | B |
Legal status | |
Routes of administration | SQ, Oral, Inhaled |
Terbutaline (trade names Brethine, Bricanyl, or Brethaire) is a β2-adrenergic receptor agonist, used as a fast-acting bronchodilator (often used as a short-term asthma treatment) and as a tocolytic to delay premature labour. The inhaled form of terbutaline starts working within 15 minutes and can last up to 6 hours.
Terbutaline as a treatment for premature labour is an off-label use not approved by the FDA. Studies have suggested that terbutaline is a developmental neurotoxicant and may cause brain damage to the infant.[1]
Side Effects[]
Maternal - tachycardia, nervousness, tremors, headache and possible pulmonary edema. Fetal - tachycardia and hypoglycemia. Terbutaline is preferred over Ritodrine because it has minimal effects on blood pressure.
References[]
- ↑ Rhodes M, Seidler F, Abdel-Rahman A, Tate C, Nyska A, Rincavage H, Slotkin T (2004). Terbutaline is a developmental neurotoxicant: effects on neuroproteins and morphology in cerebellum, hippocampus, and somatosensory cortex. J. Pharmacol. Exp. Ther. 308 (2): 529–37. Free full text
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