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Two-pore-domain potassium channels: This family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.^[1] These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.

Below is a list of the 15 known two-pore-domain human potassium channels:^[1]

See alsoEdit

• Potassium channel
• Ion channel

External linksEdit

• MeSH Tandem+Pore+Domain+Potassium+Channel

ReferencesEdit

1. ↑ ^{1.0 1.1} Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (2005). International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. Pharmacol Rev 57 (4): 527-40.