I'm no specialist, so have not edited. Cannot gluconeogenesis also be caused by excess and/or too rapid protein intake? MIchael 07:56, 24 July 2006 (UTC) Douglas Michael Massing

The diagram "showing" gluconeogenesis is actually of glycolysis. This is a significant error and needs to be changed. Here is a very brief illustration that provides a better overview of gluconeogenesis.

File:Gluconeo.png

--Dbrouse 00:02, 17 August 2006 (UTC)

The above illustration is a terrible instance of gluconeogenesis. The only problem with the diagram in the main article is its lack of distinction with glycolysis, which could be facilitated by the addition of enzymes.

The diagram in the main article does illustrate a very vague gluconeogenesis route. No enzymes are shown. However, the Gluconeogenesis pathway is similar to the reverse of Glycolysis except for the use of four different enzymes (Pyruvate carboxylase, Phosphoenolpyruvate carboxykinase, Fructose-1,6 bisphosphatase, and Glucose-6 phosphatase) which is why they look similar. You can see the Gluconeogenesis route on the right of the pathway but a better diagram should be used to see the enzymes used.

-AndyKarlesky

DisputeEdit

The accuracy of this article is disputed as the diagram shows glycolysis and not gluconeogenesis. The reverse reactions of glycolysis (shown in the image) can cause "new" glucose to be formed from small metabolites but there is more to gluconeogensis than just a reverse of glycolysis. Glycerol, from lipids, and deaminated amino acids are the major raw materials for forming new glucose.—Preceding unsigned comment added by Dbrouse (talk • contribs) Moved from article --Wafulz 05:38, 22 October 2006 (UTC)

i concur

- Mike Brubaker, Whitman College

When gluconeogenesis occurs. Edit

The article implies that gluconeogenesis only occurs during starvation or intense excercize. This is quite misleading. Gluconeogenesis is an ongoing process in the body and not isolated to specific stresses. It is essential to reuse the lactate that accumulates during excercize back into pyruvate and then into glucose. It is also the major route for glycerol metabolism. It is an important biological pathway for many other purposes.

Please update this article when the dispute is resolved at

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Dr Joe Kiff - User:Lifeartist (talk) 17:42, 2 November 2006 (UTC)