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|tachykinin, precursor 1|
|Symbol(s):||TAC1 TAC2, NKNA|
|Locus:||7 q21 -q22|
There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane g protein-coupled family of receptors and induce the activation of phospholipase C, producing inositol triphosphate. NK1, NK2 and NK3 selectively bind to substance P, neurokinin A and neurokinin B, respectively.
Neurokinin 1 is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. There are at least 2 other Neurokinin receptors, Neurokinin 2 and 3. These receptors have varying ligand affinities and activities.
Neurokinin 1 antagonists may have a role as novel antiemetics.
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