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Tumor necrosis factor

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For "tumor necrosis factor-beta", see lymphotoxin.
tumor necrosis factor
Symbol(s): TNF TNFA
Locus: 6 p21.3
EC number [1]
EntrezGene 7124
OMIM 191160
RefSeq NM_000594
UniProt P01375

In medicine, tumor necrosis factor alpha (TNFα, cachexin or cachectin) is an important cytokine involved in systemic inflammation and the acute phase response.

History and nomenclatureEdit

TNFα was isolated in 1975 by Carswell et al as a soluble factor released by host cells that caused necrosis of a transplanted tumor, "[sarcoma Meth A". Although TNFα does cause the necrosis of some tumors, it may stimulate the growth of others. In that sense, the name is somewhat of a misnomer.

Structure Edit

TNFα is a member of a group of other cytokines that all stimulate the acute phase reaction. It is a 185 amino acid glycoprotein peptide hormone, cleaved from a 212 amino acid-long propeptide on the surface of macrophages. Some cells secrete shorter or longer isoforms. Genetically it maps to chromosome 6p21.3 in humans.

Physiology Edit

TNFα is released by white blood cells, endothelium and several other tissues in the course of damage, e.g. by infection. Its release is stimulated by several other mediators, such as interleukin 1 and bacterial endotoxin. It has a number of actions on various organ systems, generally together with interleukins 1 and 6:

A locally increasing concentration of TNFα will cause the cardinal signs of Inflammation to occur: Heat, swelling, redness and pain.

Pharmacology Edit

TNFα promotes the inflammatory response, which in turn causes many of the clinical problems associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, and psoriasis. These disorders are sometimes treated by inhibiting TNFα with a monoclonal antibody such as infliximab (Remicade) or adalimumab (Humira), or with a circulating receptor fusion protein such as etanercept (Enbrel). Clinical trials regarding the effectiveness of these drugs on hidradenitis suppurativa are currently ongoing. A fourth anti-TNF biologic, certolizumab pegol, is expected to receive approval for human use in the near future.

Such drugs may raise the risk of contracting tuberculosis or causing a latent infection to become active. The anti-TNF monoclonal antibody biologics, Infliximab and adalimumab, and the fusion protein etanercept which are all currently FDA approved for human use, have label warnings which state that patients should be evaluated for latent TB infection and treatment should be initiated prior to starting therapy with these medications.

TNF or the effects of TNF are also inhibited by a number of natural compounds, including curcumin (2,3,4,5) (an ingredient in turmeric) and catechins (in green tea).

ReferencesEdit


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Target-derived NGF, BDNF, NT-3

|}de:Tumornekrosefaktor es:factor de necrosis tumoral fr:Tumor necrosis factor

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