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Subcommissural organ

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Brain: Subcommissural organ
Mesal aspect of a brain sectioned in the median sagittal plane. (Subcommissural organ not labeled, but region is visible, near the pineal .)
Latin organum subcommissurale
Gray's subject #
Part of
BrainInfo/UW hier-474
MeSH [1]

The subcommissural organ is a gland in the brain.[1] It is a circumventricular organ consisting of ependymal cells which secrete SCO-spondin.[2]

It is named for its location relative to the posterior commissure.

It is near the aqueduct of Sylvius.[3]


  1. Vio K, Rodríguez S, Yulis CR, Oliver C, Rodríguez EM (2008). The subcommissural organ of the rat secretes Reissner's fiber glycoproteins and CSF-soluble proteins reaching the internal and external CSF compartments. Cerebrospinal Fluid Res 5: 3.
  2. Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A (Dec 1996). SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation. J Cell Sci ( Pt 5): 1053–61.
  3. Rodríguez EM, Rodríguez S, Hein S (April 1998). The subcommissural organ. Microsc. Res. Tech. 41 (2): 98–123.

External linksEdit

Mesencephalon (midbrain)

cerebral peduncle: midbrain tegmentum (periaqueductal gray, ventral tegmentum, nucleus raphe dorsalis), pretectum, substantia nigra, red nucleus, pedunculopontine nucleus, medial longitudinal fasciculus, medial lemniscus, rubrospinal tract, lateral lemniscus

tectum: corpora quadrigemina, inferior colliculi, superior colliculi

cerebral aqueduct: oculomotor nucleus, trochlear nucleus, Edinger-Westphal nucleus

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