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Stephen William Kuffler (born August 24, 1913; died October 11, 1980) was a Hungarian-American neurophysiologist. He founded the Harvard Neurobiology department in 1966, and made seminal contributions to our understanding of vision, neural coding, and the neural implementation of behavior. He is known for his research on neuromuscular junctions in frogs, presynaptic inhibition, and the neurotransmitter GABA.

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