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Skene's glands

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Skene's gland
Skene's Gland
Latin '
Gray's subject #252 1213
MeSH [1]
Female anatomy
Human female internal reproductive anatomy. (Skene's gland not labeled, but region is visible.)

In human anatomy (female), the Skene's glands (also known as the lesser vestibular, periurethral glands, skene glands, paraurethral glands,[1] U-spot, or female prostate) are glands located on the anterior wall of the vagina, around the lower end of the urethra. They drain into the urethra and near the urethral opening. These glands are surrounded with tissue, which includes the part of the clitoris that reaches up inside the vagina and swells with blood during sexual arousal.

Homology and possible functions

The location of the Skene's gland is the general area of the urethral sponge. The Skene's glands are homologous with the prostate gland in males.[2]

Female ejaculation

Main article: Female ejaculation

Some believe that the Skene's glands are the source of female ejaculation.[3] In 2002, Emanuele Jannini of L'Aquila University in Italy showed that there may be an explanation both for the phenomenon and for the frequent denials of its existence. Skene's glands have highly variable anatomy, and in some extreme cases they appear to be missing entirely. If Skene's glands are the cause of female ejaculation and G-spot-orgasms, this may explain the observed absence of these phenomena in many women.[How to reference and link to summary or text] [4][5]

It has been demonstrated that a large amount of lubricating fluid (filtered blood plasma) can be secreted from this gland when stimulated from inside the vagina.

Female prostate

The fluid that emerges during female ejaculation has a composition similar to the fluid generated in males by the prostate gland,[6] containing biochemical markers of sexual function like human protein 1[7] and the enzyme PDE5. When examined with electron microscopy, both glands show similar secretory structures,[8] and both act similarly in terms of prostate-specific antigen and prostate-specific acid phosphatase studies.[9][10][11][12] Because they are increasingly perceived as merely different versions of the same gland, some researchers are moving away from the name Skene's gland and referring to it instead as the female prostate.[13]


The glands were named after the physician who described them first in Western medical literature, Elexander Skene.[14] [15]

See also


  1. Template:DorlandsDict
  2. Zaviacic M, Jakubovská V, Belosovic M, Breza J (2000). Ultrastructure of the normal adult human female prostate gland (Skene's gland). Anat Embryol (Berl) 201 (1): 51–61.
  3. Rabinerson D, Horowitz E (February 2007). [G-spot and female ejaculation: fiction or reality?]. Harefuah 146 (2): 145–7, 163.
  4. Jannini E, Simonelli C, Lenzi A (2002). Sexological approach to ejaculatory dysfunction. Int J Androl 25 (6): 317–23.
  5. Jannini E, Simonelli C, Lenzi A (2002). Disorders of ejaculation. J Endocrinol Invest 25 (11): 1006–19.
  6. Kratochvíl S (1994). Orgasmic expulsions in women. Cesk Psychiatr 90 (2): 71–7.
  7. Zaviacic, M, L Danihel, M Ruzicková, J Blazeková, Y Itoh, R Okutani, T Kawai. (March 1997). Immunohistochemical localization of human protein 1 in the female prostate (Skene's gland) and the male prostate. Histochem J. 29 (3): 219–27.
  8. Zaviacic, Z, V Jakubovská, M Belosovic, J Breza. (January 2000). Ultrastructure of the normal adult human female prostate gland (Skene's gland). Anat Embryol (Berl). 201 (1): 51–61.
  9. Zaviacic, Z, M Ruzicková, J Jakubovský, L Danihel, P Babál, J Blazeková. (November 1994). The significance of prostate markers in the orthology of the female prostate. Bratisl Lek Listy. 95 (11): 491–7.
  10. Wernert, N, M Albrech, I Sesterhenn, R Goebbels, H Bonkhoff, G Seitz, R Inniger, K Remberger. (1992). The 'female prostate': location, morphology, immunohistochemical characteristics and significance. Eur Urol. 22 (1): 64–9.
  11. Tepper, SL, J Jagirdar, D Heath, SA Geller. (May 1984). Homology between the female paraurethral (Skene's) glands and the prostate. Immunohistochemical demonstration. Arch Pathol Lab Med. 108 (5): 423–5.
  12. Pollen, JJ, A. Dreilinger (March 1984). Immunohistochemical identification of prostatic acid phosphatase and prostate specific antigen in female periurethral glands. Urology. 23 (3): 303–4.
  13. Zaviacic, Z, RJ Ablin. (January 2000). The female prostate and prostate-specific antigen. Immunohistochemical localization, implications of this prostate marker in women and reasons for using the term "prostate" in the human female. Histol Histopathol. 15 (1): 131–42.
  14. Who Named It synd/2038
  15. Skene A (1880). The anatomy and pathology of two important glands of the female urethra. Am J Obs Dis Women Child 13: 265–70.

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