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Sensitization is a non-associative learning process in which repeated administrations of a stimulus results in the progressive amplification of a response.[1] Sensitization often is characterized by an enhancement of response to a whole class of stimuli in addition to the one that is repeated. For example, repetition of a painful stimulus may make one more responsive to a loud noise.

Neural substrates of sensitizationEdit

The neural basis of behavioral sensitization is often not known, but it typically seems to result from a cellular receptor becoming more likely to respond to a stimulus. Several examples of neural sensitization include:

  • Electrical or chemical stimulation of the rat hippocampus causes strengthening of synaptic signals, a process known as long-term potentiation or LTP.[2] LTP of AMPA receptors has been proposed as a potential mechanism underlying memory and learning in the human brain.
  • In "kindling", repeated stimulation of hippocampal or amygdaloid neurons in the limbic system eventually leads to seizures in laboratory animals. After sensitization, very little stimulation may be required to produce seizures. Thus, kindling has been suggested as a model for temporal lobe epilepsy in humans, where stimulation of a repetitive type (flickering lights for instance) can cause epileptic seizures.[3] Often, people suffering from temporal lobe epilepsy report symptoms of negative effects such as anxiety and depression that might result from limbic dysfunction.[4]
  • In "central sensitization," nociceptive neurons in the dorsal horns of the spinal cord become sensitized by peripheral tissue damage or inflammation.[5] This type of sensitization has been suggested as a possible causal mechanism for chronic pain conditions. The changes of central sensitization occur after repeated trials to pain. Research from animals has consistently shown that when an trial is repeatedly exposed to a painful stimulus, the animal’s pain threshold will change and result in a stronger pain response. Researchers believe that there are parallels that can be drawn between these animal trials and persistent pain in people. For example, after a back surgery that removed a herniated disc from causing a pinched nerve, the patient may still continue to “feel” pain. Also, newborns who are circumcised without anesthesia have shown tendencies to react more greatly to future injections, vaccinations, and other similar procedures. The responses of these children are an increase in crying and a greater hemodynamic response (tachycardia and tachypnea).[6]
  • Drug sensitization occurs in drug addiction, and is defined as an increased effect of drug following repeated doses (the opposite of drug tolerance). Such sensitization involves changes in brain mesolimbic dopamine transmission, as well as a molecule inside mesolimbic neurons called delta FosB. An associative process may contribute to addiction, for environmental stimuli associated with drug taking may increase craving. This process may increase the risk for relapse in addicts attempting to quit.[7]
  • Allergic Sensitization – There is an acute response (early stages) and a late-phase response (later stages). In the early stages, the Antigen-Presenting Cell causes a response in a TH2 lymphocyte which produce the cytokine interleukin-4 (IL-4). The TH2 lymphocytes interact with B cells and together they produce IgE. IgE circulates around and binds to receptors of cells leading to an acute inflammatory response.[8] In this case, sensitization is commonly referring to commencement of allergic responses.[9] Allergic sensitization development varies with age, with younger children are at the greatest risk of developing allergic sensitization.[10] There are a variety of tests to diagnose allergic conditions. Tests that are commonly used place potential allergens on the skin of the patient and looking for a reaction to look for an allergen-specific IgE (Immunoglobulin E). They have shown that IgE levels are at their greatest before 10 years of age and fall vastly until one reaches 30.[10] There is a school of thought that believes that there are different genetic loci for different ethnicities for the same inflammatory disease.[11] By this thought, asthma has different chromosomal locations in people of European, Hispanic, Asian, and African descent.[12]

EtiologyEdit

Sensitization has been implied as a causal or maintaining mechanism in a wide range of apparently unrelated pathologies including substance abuse and dependence, allergies, asthma, and some medically unexplained syndromes such as fibromyalgia and multiple chemical sensitivity. Sensitization has also been suggested in relation to psychological disorders such as post-traumatic stress disorder, panic anxiety and mood disorders.[13][14][15]

HistoryEdit

Eric Kandel was one of the first to study the neural basis of sensitization based on his experiments observing gill withdrawal of the seaslug Aplysia in the 1960s and 1970s. Kandel and his colleagues showed that after habituation from siphon touching (gill withdrawal response weakened), applying a paired noxious electrical stimulus to the tail and a touch to the siphon, gill withdrawal was once again noted. After this sensitization, applying a light touch to the siphon, absent of noxious stimulus to the tail, Aplysia produced a strong gill withdrawal response. When tested several days after the initial trials, this response was still manifest (After Squire and Kandel, 1999[16]). In 2000, Eric Kandel was awarded the Nobel Prize in Physiology or Medicine for his research in neuronal learning processes.

See alsoEdit

References Edit

  • Antelman, S.M. (1988). Time-dependent sensitization as the cornerstone for a new approach to pharmacotherapy: drugs as foreign/stressful stimuli. Drug Development Research, 14, 1-30.
  • Bell, I.R., Hardin, E.E., Baldwin, C.M., & Schwartz, G.E. (1995). Increased limbic system symptomatology and sensitizability of young adults with chemical and noise sensitivities. Environmental Research, 70, 84-97.
  • Collingridge, G.L., Isaac, J.T.R., & Wang, Y.T. (2004). Receptor trafficking and synaptic plasticity. Nature Reviews, 5, 952-962.
  • Ji, R., Kohno, T., Moore, K.A. & Woolf, C.J. (2003). Central sensitization and LTP: do pain and memory share similar mechanisms? Trends in Neurosciences, 26, 696-705. Full text
  • Kandel, E.R. (2004). The molecular biology of memory storage: a dialog between genes and synapses. Bioscience Reports, 24, 477-522. Full text
  • Morimoto, K., Fahnestock, M. & Racine, R.J. (2004). Kindling and status epilepticus models of epilepsy: rewiring the brain. Progress in Neurobiology, 73, 1-60.
  • Rosen, J.B. & Schulkin, J. (1998). From normal fear to pathological anxiety. Psychological Review, 105, 325-350.

Further readingEdit

  • Antzoulatos, E.G., Wainwright, M.L., Cleary, L.J., & Byrne, J.H. (2006). Long-term sensitization training primes Aplysia for further learning. Learning & Memory, 13, 422-425. Full text
  • Barbas, D., DesGroseillers, L., Castellucci, V.F., Carew, T.J., & Marinesco, S. (2003). Multiple Serotonergic Mechanisms Contributing to Sensitization in Aplysia: Evidence of Diverse Serotonin Receptor Subtypes. Learning & Memory, 10, 373 - 386. Full text
  • Burrell, B.D. & Sahley, C.L. (1998). Generalization of Habituation and Intrinsic Sensitization in the Leech. Learning & Memory, 5, 405 - 419. Full text
  • Burrell, B.D. & Sahley, C.L. (1999). Serotonin Depletion Does Not Prevent Intrinsic Sensitization in the Leech. Learning & Memory, 6, 509 - 520. Full text
  • Hawkins, R.D., Cohen, T.E., & Kandel, E.R. (2006). Dishabituation in Aplysia can involve either reversal of habituation or superimposed sensitization. Learning & Memory, 13, 397-403. Full text
  • Kaplan, P.S., Goldstein, M.H., Huckeby, E.R., & Cooper, R.P. (1995). Habituation, sensitization, and infants' responses to motherese speech. Developmental Psychobiology, 28, 45-57. Full text
  • McSweeney, F.K., Hinson, J.M, & Cannon, C.B. (1996). Sensitization-habituation may occur during operant conditioning. Psychological Bulletin, 120, 256-271. Full text
  • Philips, G.T., Tzvetkova, E.I., Marinesco, S., & Carew, T.J. (2006). Latent memory for sensitization in Aplysia. Learning & Memory, 13, 224 - 229. Full text
  • Shum, F.W.F., et. al. (2007). Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment. Learning & Memory, 14, 304 - 312. Abstract
  • Sutton, M.A., Ide, J., Masters, S.E., & Carew, T.J. (2002). Interaction between Amount and Pattern of Training in the Induction of Intermediate- and Long-Term Memory for Sensitization in Aplysia. Learning & Memory, 9, 29 - 40. Full text


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