Semantic dementia

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Semantic dementia (SD) is a progressive neurodegenerative language disorder characterized by fluent, empty speech and loss of word meaning. SD is one of three clinical syndromes associated with frontotemporal lobar degeneration. SD is a clinically-defined syndrome, but it is sometimes anatomically defined as the temporal variant of frontotemporal lobar degeneration (tvFTLD).

[edit] Signs and Symptoms

SD patients complain of word-finding difficulties. Neuropsychology testing reveals deficits in picture naming, category fluency (e.g. "Please list as many animals as you can in one minute") and non-verbal tasks where the patient is given three photos and asked to point to a semantically related pair (known as "the pyramid and palm tree task," in which the third item is a pine tree). As the disease progresses, behavioral and personality changes are often seen similar to those seen in frontotemporal dementia.

[edit] Anatomy

SD is associated with gray matter atrophy in the temporal poles (usually left more than right), insula, and ventromedial and orbitofrontal cortex.

[edit] References

Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF. "Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria." 'Neurology' (1998) 51(6):1546-54. Available: [1]
Kramer JH, Jurik J, Sha SJ, Rankin KP, Rosen HJ, Johnson JK, Miller BL. "Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease." Cogn Behav Neurol. (2003) 16(4):211-8. Available: [2]
Rosen HJ, Gorno-Tempini ML, Goldman WP, Perry RJ, Schuff N, Weiner M, Feiwell R, Kramer JH, Miller BL. "Patterns of brain atrophy in frontotemporal dementia and semantic dementia." Neurology (2002) 58(2):198-208. Available: [3]

[edit] See also

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This page uses content from the English-language version of Wikipedia. The original article was at Semantic dementia. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.

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