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{{BioPsy}}
  
{{BioPsy}}
   
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{{merge|hypnotic}}
  
   
−
A '''sedative''' is a [[psychoactive drug|drug]] that depresses the [[central nervous system]] (CNS), which causes calmness, relaxation, reduction of [[anxiety]], [[Sleep#Sleepiness|sleepiness]], slowed breathing, slurred speech, staggering [[gait (human)|gait]], poor judgment, and slow, uncertain [[reflex]]es. Sedatives may be referred to as '''tranquilizers''', [[depressant]]s, anxiolytics, soporifics, '''sleeping pills''', '''downers''', or sedative-hypnotics. At high doses or when they are abused, many of these drugs can cause [[unconsciousness]] and [[death]].
+
A '''sedative''' is a substance which depresses the [[central nervous system]] (CNS), resulting in calmness, relaxation, reduction of [[anxiety]], [[Sleep#Sleepiness|sleepiness]], slowed breathing, slurred speech, staggering [[gait (human)|gait]], poor judgment, and slow, uncertain [[reflex]]es. Sedatives may be referred to as '''tranquilizers''', [[depressant]]s, anxiolytics, soporifics, '''sleeping pills''', '''downers''', or sedative-hypnotics. At high doses or when they are abused, many of these drugs can cause [[unconsciousness]] (see [[hypnotic]]) and [[death]].
   
−
==Types of sedative==
 +
==Types of sedatives==
 
*[[Antidepressant]]s
  
*[[Antidepressant]]s
−
**[[mirtazapine]] (Remeron)
+
**[[mirtazapine]] (Remeron®)
  +
**[[trazodone]] (Desyrel®)
 
*[[Barbiturate]]s
  
*[[Barbiturate]]s
−
**[[secobarbital]] (Seconal)
 +
**[[secobarbital]] (Seconal®)
−
**[[pentobarbital]] (Nembutal)
 +
**[[pentobarbital]] (Nembutal®)
−
**[[amobarbital]] (Amytal)
 +
**[[amobarbital]] (Amytal®)
 
*[[Benzodiazepine]]s ("minor tranquilizers")
  
*[[Benzodiazepine]]s ("minor tranquilizers")
−
**[[diazepam]] (Valium)
 +
**[[alprazolam]] (Xanax®)
−
**[[clonazepam]] (Klonopin)
 +
**[[diazepam]] (Valium®)
−
**[[alprazolam]] (Xanax)
 +
**[[lorazepam]] (Atavan®)
  ⚫
**[[Typical antipsychotic]]s ("major tranquilizers")
−
**[[temazepam]] (Restoril)
  
−
**[[chlordiazepoxide]] (Librium)
 +
***[[fluphenazine]] (Prolixin®)
−
**[[flunitrazepam]] (Rohypnol)
 +
***[[haloperidol]] (Haldol®)
−
**[[lorazepam]] (Ativan)
 +
***[[loxapine succinate]] (Loxitane®)
−
**[[clorazepate]] (Tranxene)
 +
***[[perphenazine]] (Etrafon®, Trilafon®)
  ⚫
***[[prochlorperazine]] (Compazine®)
−
*[[Imidazopyridine]]s
  
−
**[[zolpidem]] (Ambien)
 +
***[[thiothixene]] (Navane®)
  +
***[[trifluoperazine]] (Stelazine®, Trifluoperaz®)
−
**[[alpidem]]
  
−
*[[Pyrazolopyrimidine]]s
 +
**[[Atypical antipsychotic]]s
−
**[[Zaleplon]] (Sonata)
 +
***[[clozapine]] (Clozaril®)
  ⚫
***[[quetiapine]] (Seroquel®)
−
*[[Antihistamine]]s
  
−
**[[diphenhydramine]] (Benadryl, Sominex)
 +
***[[risperidone]] (Risperdal®)
  ⚫
***[[ziprasidone]] (Geodon®) (It may make some people tired, while causing insomnia in others)
−
**[[dimenhydrinate]] (Dramamine)
  
−
**[[doxylamine]]
 +
***[[olanzapine]] (Zyprexa®)
−
*[[Antipsychotics]]
  
⚫
**[[Typical antipsychotic]] ("major tranquilizers")
  
−
***[[Fluphenazine]] (Prolixin)
  
−
***[[Haloperidol]] (Haldol)
  
−
***[[Thiothixene]]
  
−
***[[Trifluoperazine]]
  
−
***[[Loxapine]] (Loxitane)
  
−
***[[Perphenazine]]
  
⚫
***[[Prochlorperazine]] (Compazine)
  
−
**[[Atypical antipsychotic]]
  
−
***[[clozapine]] (Clozaril)
  
⚫
***[[quetiapine]] (Seroquel)
  
−
***[[Risperidone]] (Risperdal)
  
⚫
***[[Ziprasidone]] (Geodon)(It may make some people tired, while making others unable to sleep)
  
 
*Herbal sedatives
  
*Herbal sedatives
−
**[[valerian plant]]
 +
**[[Nepeta|catnip]]
  +
**[[Valerian (plant)]]
 
**[[Mandrake (plant)|Mandrake]]
  
**[[Mandrake (plant)|Mandrake]]
−
**[[kava]]
 +
**[[Kava Kava]]
 
*Uncategorized sedatives
  
*Uncategorized sedatives
−
**[[methaqualone]] (Sopor, Quaalude)
 +
**[[chloral hydrate]] (Noctec®)
−
**[[ethchlorvynol]] (Placidyl)
 +
**[[diethyl ether]] (Ether)
−
**[[chloral hydrate]] (Noctec)
 +
**[[eszopiclone]] (Lunesta®)
−
**[[meprobamate]] (Miltown)
 +
**[[ethchlorvynol]] (Placidyl®)
−
**[[glutethimide]] (Doriden)
 +
**[[ethyl alcohol]] ([[alcoholic beverage]])
⚫
**[[methyprylon]] (Noludar)
  
 
**[[gamma-hydroxybutyrate]] (GHB)
  
**[[gamma-hydroxybutyrate]] (GHB)
−
**[[ethyl alcohol]] ([[Alcoholic beverage]])
 +
**[[glutethimide]] (Doriden®)
−
**[[diethyl ether]] ([[Ether]])
 +
**[[meprobamate]] (Miltown®)
  +
**[[methaqualone]] (Sopor®, Quaalude®)
−
**[[chloroform|methyl trichloride]] ([[Chloroform]])
 +
**[[methyl trichloride]] (Chloroform)
⚫
**[[Zopiclone]] ([[Imovane]], [[Zimovane]])
  
  ⚫
**[[methyprylon]] (Noludar®)
  +
**[[ramelteon]] (Rozerem®)
  +
**[[zaleplon]] (Sonata®)
  +
**[[zolpidem]] (Ambien®)
  ⚫
**[[zopiclone]] (Imovane®, Zimovane®)
   
 
==Therapeutic use==
  
==Therapeutic use==
−
[[Physician|Doctor]]s and [[nurse]]s often administer [[sedation]] to patients in order to dull the patient's anxiety related to painful or anxiety-provoking procedures. Athough sedatives do not relieve pain in themselves, they can be a useful adjunct to [[analgesic]]s in preparing patients for [[surgery]], and are commonly given to patients before they are [[anaesthesia|anaesthetized]], or before other highly uncomfortable and invasive procedures like cardiac [[catheterization]] or [[MRI]]. They increase tractability and compliance of children or troublesome or demanding patients.
+
[[Physician|Doctor]]s and [[nurse]]s often administer [[Sedation|sedation]] to patients in order to dull the patient's anxiety related to painful or anxiety-provoking procedures. Although sedatives do not relieve pain in themselves, they can be a useful adjunct to [[analgesic]]s in preparing patients for [[surgery]], and are commonly given to patients before they are [[anaesthesia|anaesthetized]], or before other highly uncomfortable and invasive procedures like cardiac [[catheterization]] or [[MRI]]. They increase tractability and compliance of children or troublesome or demanding patients.
   
 
Patients in [[intensive care]] units are almost always sedated (unless they are unconscious from their condition anyway).
  
Patients in [[intensive care]] units are almost always sedated (unless they are unconscious from their condition anyway).
   
 
==Sedative dependence==
  
==Sedative dependence==
−
All sedatives can cause physical and psychological dependence when taken regularly over a period of time, even at therapeutic doses. When dependent users decrease or end use suddenly, they will exhibit [[withdrawal]] symptoms ranging from restlessness, [[insomnia]] and [[anxiety]] to convulsions and death. When users become psychologically dependent, they feel as if they need the drug to function although there is no biological dependence. In both types of dependence, finding and using the drug becomes the focus in life. Both physical and psychological dependence can be treated (see [http://www.mentalhealth.com/rx/p23-sb10.html Sedative Dependence]).
 +
All sedatives can cause physiological and psychological dependence when taken regularly over a period of time, even at therapeutic doses. When dependent users decrease or end use suddenly, they will exhibit [[withdrawal]] symptoms ranging from restlessness, [[insomnia]] and [[anxiety]] to convulsions and death. When users become psychologically dependent, they feel as if they need the drug to function although there is no biological dependence. In both types of dependence, finding and using the drug becomes the focus in life. Both physical and psychological dependence can be treated (see [http://www.mentalhealth.com/rx/p23-sb10.html Sedative Dependence]).
   
 
==Abuse and overdoses==
  
==Abuse and overdoses==
−
All sedatives can be abused, but barbiturates are responsible for most of the problems with sedative abuse due to their widespread "recreational" or non-medical use, as well as over-prescribing by medical doctors. People who have difficulty dealing with stress, anxiety or sleeplessness may overuse or become dependent on sedatives. [[Heroin]] users take them either to supplement their drug or to substitute for it. [[Stimulant]] users frequently take sedatives to calm excessive jitteriness. Others take sedatives recreationally to relax and forget their worries. Barbiturate overdose is a factor in nearly one-third of all reported drug-related deaths. These include [[suicide]]s and accidental drug poisonings. Accidental deaths sometimes occur when a drowsy, confused user repeats doses. In the US, in 1998, a total of 70,982 sedative exposures were reported to US [[poison]] control centers, of which 2310 (3.2%) resulted in major [[toxicity]] and 89 (0.1%) resulted in death. About half of all the people admitted to emergency rooms in the US as a result of nonmedical use of sedatives have a legitimate prescription for the drug, but have taken an excessive dose or combined it with alcohol or other drugs. Others get sedatives from friends who have authentic prescriptions or by using fake prescriptions.
 +
All sedatives can be abused, but barbiturates are responsible for most of the problems with sedative abuse due to their widespread "recreational" or non-medical use. People who have difficulty dealing with stress, anxiety or sleeplessness may overuse or become dependent on sedatives. [[Heroin]] users take them either to supplement their drug or to substitute for it. [[Stimulant]] users frequently take sedatives to calm excessive jitteriness. Others take sedatives recreationally to relax and forget their worries. Barbiturate overdose is a factor in nearly one-third of all reported drug-related deaths. These include [[suicide]]s and accidental drug poisonings. Accidental deaths sometimes occur when a drowsy, confused user repeats doses. In the US, in 1998, a total of 70,982 sedative exposures were reported to US [[poison]] control centers, of which 2310 (3.2%) resulted in major [[toxicity]] and 89 (0.1%) resulted in death. About half of all the people admitted to emergency rooms in the US as a result of nonmedical use of sedatives have a legitimate prescription for the drug, but have taken an excessive dose or combined it with alcohol or other drugs. Others get sedatives from friends who have authentic prescriptions or by using fake prescriptions.
   
−
See also [[Barbiturate#Other_non-therapeutical_use|Other non-therapeutical use]].
 +
See also [[Barbiturate#Other non-therapeutical use|Other non-therapeutical use]].
   
 
==Sedatives and alcohol==
  
==Sedatives and alcohol==
−
Sedatives and [[alcohol]] are sometimes combined recreationally or carelessly. Since alcohol also is a strong CNS depressant that slows [[brain]] function and depresses respiration, the two substances reinforce each other and this combination can prove fatal. [[Karen Ann Quinlan]] collapsed into a [[coma]] after swallowing alcohol and tranquilizers at a party in 1975. Her case spurred worldwide discussion of the ethics surrounding termination of life-sustaining treatment.
 +
Sedatives and [[alcohol]] are sometimes combined recreationally or carelessly. Since alcohol also is a strong CNS depressant that slows [[brain]] function and depresses respiration, the two substances contradict each other and this combination can prove fatal. [[Karen Ann Quinlan]] collapsed into a [[coma]] after swallowing alcohol and tranquilizers at a party in 1975. Her case spurred worldwide discussion of the ethics surrounding termination of life-sustaining treatment.
   
 
==Lookalikes==
  
==Lookalikes==
 
Lookalikes, or pills made to mimic the appearance and the effects of authentic sedatives, are sold on the street. Lookalikes may contain over-the-counter drugs, such as antihistamines, that cause drowsiness. Like any other drug that is illicitly manufactured and sold, their composition and effects cannot be predicted.
  
Lookalikes, or pills made to mimic the appearance and the effects of authentic sedatives, are sold on the street. Lookalikes may contain over-the-counter drugs, such as antihistamines, that cause drowsiness. Like any other drug that is illicitly manufactured and sold, their composition and effects cannot be predicted.
  +
  +
==Sedatives and amnesia==
  +
Sedation can sometimes leave the patient with long-term or short-term [[Amnesia|amnesia]].
  +
[[Lorazepam]] is one such pharmacological agent that can cause [[anterograde amnesia]]. [[Intensive Care Unit]] patients who receive higher doses over longer periods of time, typically via [[Intravenous therapy|IV drip]], are more likely to experience such side effects.
  +
  +
{{sect-stub}}
   
 
==Sedative drugs and crime==
  
==Sedative drugs and crime==
Line 87: Line 84:
 
*[[Psychoactive drug]]
  
*[[Psychoactive drug]]
   
−
==External Links==
 +
==External links==
 
*[http://corp.aadac.com/other_drugs/the_basics_about_other_drugs/tranquillizers_abcs.asp Tranquillizers and Sleeping Pills: The ABCs]
  
*[http://corp.aadac.com/other_drugs/the_basics_about_other_drugs/tranquillizers_abcs.asp Tranquillizers and Sleeping Pills: The ABCs]
  +
  +
{{Sedative}}
  +
{{Barbiturates}}
  +
{{Benzodiazepines}}
   
 
[[Category:Sedatives]]
  
[[Category:Sedatives]]
 
[[Category:Sleep]]
  
[[Category:Sleep]]
   
−
[[de:Tranquilizer]]
 +
[[cs:Sedativum]]
  +
[[de:Tranquillanzien]]
  +
[[es:Sedante]]
 
[[fr:Sédatif]]
  
[[fr:Sédatif]]
 
[[lv:Trankvilizatori]]
  
[[lv:Trankvilizatori]]
Line 101: Line 104:
 
[[ru:Транквилизатор]]
  
[[ru:Транквилизатор]]
 
[[simple:Sedative]]
  
[[simple:Sedative]]
  +
[[sr:Транквилајзери]]
 
[[fi:Sedatiivi]]
  
[[fi:Sedatiivi]]
 
[[zh:安眠药]]
  
[[zh:安眠药]]

Revision as of 09:41, 13 November 2006

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A sedative is a substance which depresses the central nervous system (CNS), resulting in calmness, relaxation, reduction of anxiety, sleepiness, slowed breathing, slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes. Sedatives may be referred to as tranquilizers, depressants, anxiolytics, soporifics, sleeping pills, downers, or sedative-hypnotics. At high doses or when they are abused, many of these drugs can cause unconsciousness (see hypnotic) and death.

Types of sedatives

Therapeutic use

Doctors and nurses often administer sedation to patients in order to dull the patient's anxiety related to painful or anxiety-provoking procedures. Although sedatives do not relieve pain in themselves, they can be a useful adjunct to analgesics in preparing patients for surgery, and are commonly given to patients before they are anaesthetized, or before other highly uncomfortable and invasive procedures like cardiac catheterization or MRI. They increase tractability and compliance of children or troublesome or demanding patients.

Patients in intensive care units are almost always sedated (unless they are unconscious from their condition anyway).

Sedative dependence

All sedatives can cause physiological and psychological dependence when taken regularly over a period of time, even at therapeutic doses. When dependent users decrease or end use suddenly, they will exhibit withdrawal symptoms ranging from restlessness, insomnia and anxiety to convulsions and death. When users become psychologically dependent, they feel as if they need the drug to function although there is no biological dependence. In both types of dependence, finding and using the drug becomes the focus in life. Both physical and psychological dependence can be treated (see Sedative Dependence).

Abuse and overdoses

All sedatives can be abused, but barbiturates are responsible for most of the problems with sedative abuse due to their widespread "recreational" or non-medical use. People who have difficulty dealing with stress, anxiety or sleeplessness may overuse or become dependent on sedatives. Heroin users take them either to supplement their drug or to substitute for it. Stimulant users frequently take sedatives to calm excessive jitteriness. Others take sedatives recreationally to relax and forget their worries. Barbiturate overdose is a factor in nearly one-third of all reported drug-related deaths. These include suicides and accidental drug poisonings. Accidental deaths sometimes occur when a drowsy, confused user repeats doses. In the US, in 1998, a total of 70,982 sedative exposures were reported to US poison control centers, of which 2310 (3.2%) resulted in major toxicity and 89 (0.1%) resulted in death. About half of all the people admitted to emergency rooms in the US as a result of nonmedical use of sedatives have a legitimate prescription for the drug, but have taken an excessive dose or combined it with alcohol or other drugs. Others get sedatives from friends who have authentic prescriptions or by using fake prescriptions.

See also Other non-therapeutical use.

Sedatives and alcohol

Sedatives and alcohol are sometimes combined recreationally or carelessly. Since alcohol also is a strong CNS depressant that slows brain function and depresses respiration, the two substances contradict each other and this combination can prove fatal. Karen Ann Quinlan collapsed into a coma after swallowing alcohol and tranquilizers at a party in 1975. Her case spurred worldwide discussion of the ethics surrounding termination of life-sustaining treatment.

Lookalikes

Lookalikes, or pills made to mimic the appearance and the effects of authentic sedatives, are sold on the street. Lookalikes may contain over-the-counter drugs, such as antihistamines, that cause drowsiness. Like any other drug that is illicitly manufactured and sold, their composition and effects cannot be predicted.

Sedatives and amnesia

Sedation can sometimes leave the patient with long-term or short-term amnesia. Lorazepam is one such pharmacological agent that can cause anterograde amnesia. Intensive Care Unit patients who receive higher doses over longer periods of time, typically via IV drip, are more likely to experience such side effects.

Sedative drugs and crime

The sedative GHB is known for its use as a date rape drug, administered to unsuspecting patrons in bars or guests at parties to reduce the intended victims' defenses.

See also

External links


Sedatives edit

(Methaqualone) (Ethchlorvynol) (Chloral Hydrate) (Meprobamate) (Glutethimide) (Methyprylon) (Gamma-hydroxybutyrate) (Gamma-butyrolactone) (Propofol)


Barbiturates edit

{Amobarbital) {Aprobarbital) {Butabarbital) {Butalbital) {Hexobarbital) {Mephobarbital) {Pentobarbital) {Phenobarbital) {Secobarbital) {Sodium thiopental) {Talbutal) {Thiobarbital)

v·d·e
Benzodiazepines (N05BA, N05CD)
1,4-Benzodiazepines

Bromazepam • Camazepam • Carburazepam • Chlordiazepoxide • Cinolazepam • Clonazepam • Clorazepate • Cyprazepam • Delorazepam • Demoxepam • Diazepam • Doxefazepam • Elfazepam • Ethyl carfluzepate • Ethyl dirazepate • Ethyl loflazepate • Fletazepam • Fludiazepam • Flunitrazepam • Flurazepam • Flutemazepam • Flutoprazepam • Fosazepam • Gidazepam • Halazepam • Iclazepam • Lopirazepam • Lorazepam • Lormetazepam • Meclonazepam • Medazepam • Menitrazepam • Metaclazepam • Motrazepam • Nimetazepam • Nitrazepam • Nitrazepate • Nordazepam • Nortetrazepam • Oxazepam • Phenazepam • Pinazepam • Pivoxazepam • Prazepam • Proflazepam • Quazepam • QH-II-66 • Reclazepam • Sulazepam • Temazepam • Tetrazepam • Tolufazepam • Tuclazepam • Uldazepam


1,5-Benzodiazepines

Arfendazam • Clobazam • Lofendazam • Triflubazam

2,3-Benzodiazepines

Girisopam • GYKI-52466 • GYKI-52895 • Nerisopam • Tofisopam

Triazolobenzodiazepines

Adinazolam • Alprazolam • Estazolam • Flubromazolam • Triazolam 


Imidazobenzodiazepines

Bretazenil • Climazolam • Flumazenil • Imidazenil • L-655,708 • Loprazolam • Midazolam • PWZ-029 • Ro15-4513 • Ro48-6791 • Ro48-8684 • Sarmazenil • SH-053-R-CH3-2′F


Oxazolobenzodiazepines

Cloxazolam • Flutazolam • Haloxazolam • Mexazolam • Oxazolam


Thienodiazepines

Brotizolam • Ciclotizolam • Clotiazepam • Etizolam

Pyridodiazepines

Zapizolam • Lopirazepam

Pyrazolodiazepines

Ripazepam • Zolazepam • Zomebazam

Pyrrolodiazepines

Premazepam

Benzodiazepine Prodrugs

Avizafone • Rilmazafone

Others

Bentazepam • Devazepide • Ketazolam • Razobazam • Tifluadom



Antihistamines edit

(Acrivastine) (Astemizole) (Azelastine) (Brompheniramine) (Carbinoxamine) (Cetirizine) (Chlorphenamine) (Clemastine) (Desloratadine) (Dimenhydrinate) (Diphenhydramine) (Doxylamine) (Loratadine) (Fexofenadine) (Meclizine) (Promethazine) (Triprolidine)


Herbal Sedatives edit

(Valerian plant) (Salvia) (Cannabis) (Datura) (Kava) (Mandrake)


Barbiturates edit

Allobarbital, Amobarbital, Aprobarbital, Barbexaclone, Barbital, Butabarbital, Butalbital, Butobarbital, Cyclobarbital, Ethallobarbital, Heptabarbital, Hexobarbital, Mephobarbital, Metharbital, Methohexital, Methylphenobarbital, Pentobarbital, Phenobarbital, Primidone, Proxibarbal, Reposal, Secobarbital, Talbutal, Thiobarbital, Thiopental, Vinbarbital, Vinylbital

v·d·e
Benzodiazepines (N05BA, N05CD)
1,4-Benzodiazepines

Bromazepam • Camazepam • Carburazepam • Chlordiazepoxide • Cinolazepam • Clonazepam • Clorazepate • Cyprazepam • Delorazepam • Demoxepam • Diazepam • Doxefazepam • Elfazepam • Ethyl carfluzepate • Ethyl dirazepate • Ethyl loflazepate • Fletazepam • Fludiazepam • Flunitrazepam • Flurazepam • Flutemazepam • Flutoprazepam • Fosazepam • Gidazepam • Halazepam • Iclazepam • Lopirazepam • Lorazepam • Lormetazepam • Meclonazepam • Medazepam • Menitrazepam • Metaclazepam • Motrazepam • Nimetazepam • Nitrazepam • Nitrazepate • Nordazepam • Nortetrazepam • Oxazepam • Phenazepam • Pinazepam • Pivoxazepam • Prazepam • Proflazepam • Quazepam • QH-II-66 • Reclazepam • Sulazepam • Temazepam • Tetrazepam • Tolufazepam • Tuclazepam • Uldazepam


1,5-Benzodiazepines

Arfendazam • Clobazam • Lofendazam • Triflubazam

2,3-Benzodiazepines

Girisopam • GYKI-52466 • GYKI-52895 • Nerisopam • Tofisopam

Triazolobenzodiazepines

Adinazolam • Alprazolam • Estazolam • Flubromazolam • Triazolam 


Imidazobenzodiazepines

Bretazenil • Climazolam • Flumazenil • Imidazenil • L-655,708 • Loprazolam • Midazolam • PWZ-029 • Ro15-4513 • Ro48-6791 • Ro48-8684 • Sarmazenil • SH-053-R-CH3-2′F


Oxazolobenzodiazepines

Cloxazolam • Flutazolam • Haloxazolam • Mexazolam • Oxazolam


Thienodiazepines

Brotizolam • Ciclotizolam • Clotiazepam • Etizolam

Pyridodiazepines

Zapizolam • Lopirazepam

Pyrazolodiazepines

Ripazepam • Zolazepam • Zomebazam

Pyrrolodiazepines

Premazepam

Benzodiazepine Prodrugs

Avizafone • Rilmazafone

Others

Bentazepam • Devazepide • Ketazolam • Razobazam • Tifluadom

cs:Sedativum de:Tranquillanzien es:Sedante fr:Sédatif lv:Trankvilizatori no:Sedativ pt:Sedativo ru:Транквилизатор simple:Sedative sr:Транквилајзери fi:Sedatiivi zh:安眠药

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