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Template:Pfam box

Secretin family of 7 transmembrane receptors is a family of evolutionarily related proteins.^[1]

This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors.They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families (B1-B3) are recognized. Many secretin receptors are regulated by peptide hormoness from the glucagon hormone family.

The secretin-like GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide receptors, all of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. These receptors have 7 transmembrane helices, like rhodopsin-like GPCRs. However,there is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique '7TM' signature.

Subfamily B1 Edit

Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways.

• Adenylate cyclase-activating type 1 receptor, pituitary Template:InterPro
  • ADCYAP1R1
• Calcitonin receptor Template:InterPro
  • CALCR; CALCRL
• Corticotropin-releasing hormone receptor Template:InterPro
  • CRHR1; CRHR2
• Glucagon receptor-related Template:InterPro
  • GLP1R; GLP2R; GPCR
• Growth hormone releasing hormone receptor Template:InterPro
  • GHRHR
• Parathyroid hormone receptor Template:InterPro
  • PTHR1; PTHR2
• Secretin receptor Template:InterPro
  • SCTR
• Vasoactive intestinal peptide receptor Template:InterPro
  • VIPR1; VIPR2

Subfamily B2 Edit

Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin (such as UniProt O94910, and brain-specific angiogenesis inhibitor receptors (such as UniProt O14514) amongst others.

• Brain-specific angiogenesis inhibitor Template:InterPro
  • BAI1; BAI2; BAI3
• CD97 antigen Template:InterPro
  • CD97
• EMR hormone receptor Template:InterPro
  • CELSR1; CELSR2; CELSR3; EMR1; EMR2; EMR3; EMR4
• Gastric inhibitory polypeptide receptor Template:InterPro
  • GCGR; GIPR
• GPR56 orphan receptor Template:InterPro
  • GPR56; GPR64; GPR97; GPR110; GPR111; GPR112; GPR113; GPR114; GPR115; GPR123; GPR125; GPR126; GPR128; GPR133; GPR144; GPR157
• Latrophilin receptor Template:InterPro
  • ELTD1; LPHN1; LPHN2; LPHN3

Subfamily B3 Edit

Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.

• Diuretic hormone receptor Template:InterPro

Unclassified subfamiliesEdit

• Ig-hepta receptor Template:InterPro
  • GPR116

Unclassified membersEdit

DREG; HCTR-5; HCTR-6; KPG_003; KPG_006; KPG_008; KPG_009; RESDA1

ReferencesEdit