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Secretin receptor

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Secretin receptor
Symbol(s) SCTR; SR
External IDs OMIM: 182098 Homologene68290
RNA expression pattern


More reference expression data

Human Mouse Entrez 6344 na Ensembl ENSG00000080293 na Uniprot P47872 na Refseq NM_002980 (mRNA)
NP_002971 (protein)
na (mRNA)
na (protein)
Location Chr 2: 119.91 - 120 Mb na
Pubmed search [1] na

Human secretin receptor (gene name SCTR) is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the class B GPCR subfamily.[1]

References Edit

  1. Dong M, Miller LJ (2002). Molecular pharmacology of the secretin receptor. Recept. Channels 8 (3-4): 189–200.

Further readingEdit

  • Ulrich CD, Holtmann M, Miller LJ (1998). Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors.. Gastroenterology 114 (2): 382-97.
  • Felley CP, Qian JM, Mantey S, et al. (1993). Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release.. Am. J. Physiol. 263 (6 Pt 1): G901-7.
  • Ishihara T, Nakamura S, Kaziro Y, et al. (1991). Molecular cloning and expression of a cDNA encoding the secretin receptor.. EMBO J. 10 (7): 1635-41.
  • Robberecht P, De Neef P, Waelbroeck M, et al. (1988). Secretin receptors in human pancreatic membranes.. Pancreas 3 (5): 529-35.
  • Chow BK (1995). Molecular cloning and functional characterization of a human secretin receptor.. Biochem. Biophys. Res. Commun. 212 (1): 204-11.
  • Patel DR, Kong Y, Sreedharan SP (1995). Molecular cloning and expression of a human secretin receptor.. Mol. Pharmacol. 47 (3): 467-73.
  • Holtmann MH, Hadac EM, Miller LJ (1995). Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors.. J. Biol. Chem. 270 (24): 14394-8.
  • Jiang S, Ulrich C (1995). Molecular cloning and functional expression of a human pancreatic secretin receptor.. Biochem. Biophys. Res. Commun. 207 (3): 883-90.
  • Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (1993). Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor.. Biochem. Biophys. Res. Commun. 193 (2): 546-53.
  • Mark HF, Chow BK (1996). Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry.. Genomics 29 (3): 817-8.
  • Vilardaga JP, di Paolo E, de Neef P, et al. (1996). Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin.. Biochem. Biophys. Res. Commun. 218 (3): 842-6.
  • Chow BK (1998). Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor.. Receptors & signal transduction 7 (3): 143-50.
  • Shetzline MA, Premont RT, Walker JK, et al. (1998). A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor.. J. Biol. Chem. 273 (12): 6756-62.
  • Ho PK, Fong RS, Kai HS, et al. (1999). The human secretin receptor gene: genomic organization and promoter characterization.. FEBS Lett. 455 (3): 209-14.
  • Pang RT, Ng SS, Cheng CH, et al. (1999). Role of N-linked glycosylation on the function and expression of the human secretin receptor.. Endocrinology 140 (11): 5102-11.
  • Chan KY, Pang RT, Chow BK (2001). Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor.. Endocrinology 142 (9): 3926-34.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903.
  • Pang RT, Lee LT, Ng SS, et al. (2004). CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene.. Mol. Endocrinol. 18 (2): 471-83.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 (1): 40-5.

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