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Schizophrenia - Molecular genetic studies of schizophrenia loci

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There is currently a great deal of effort being put into molecular genetic studies of schizophrenia, which attempt to identify specific genes which may increase risk these genetic marker studies can greatly improve the prospect of detecting a major gene effect.

Methodology of genetic marker studies in schizophreniaEdit

Current findingsEdit

A 2003 review of linkage studies listed seven genes as likely to increase risk for a later diagnosis of the disorder.[1] Two more recent reviews[2][3] have suggested that the evidence is currently strongest for two genes known as dysbindin (DTNBP1) and neuregulin (NRG1), with a number of other genes (such as COMT, RGS4, PPP3CC, ZDHHC8, DISC1, and AKT1) showing some early promising results that have not yet been fully replicated.

In 2007, British researches have identified seven different genetic variations that are associated with schizophrenia and which all lie within or very near a gene FXYD6.[4] This gene, which lies on the long arm of chromosome 11, plays an important role in regulating Na/K homeostasis.

Evidence for of schizophrenia loci on each chromosomeEdit

This picture suggests that it is unlikely that one major locus exists for schizophrenia. It seems more likely that schizophrenia belongs to a class of complex disorders that have a genetic predisposition.


See alsoEdit

References & BibliographyEdit

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  2. Cite error: Invalid <ref> tag; no text was provided for refs named fn_75
  3. Riley B, Kendler KS (2006) Molecular genetic studies of schizophrenia. Eur J Hum Genet, 14 (6), 669-80.
  4. Getting Crowded on Chromosome 11q22—Make Way for Phosphohippolin

Key textsEdit

BooksEdit

PapersEdit

  • Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub R, Goldman D, Weinberger DR.(2001) Effect of COMT Val Met genotype on frontal lobe function and risk for schizophrenia. PNAS , 98:6917-6922.

Additional materialEdit

BooksEdit

PapersEdit

External linksEdit

OHIM schizophrenia psge

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