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Megavitamin therapy advocates Abram Hoffer and Humphry Osmond claimed that adrenochrome is a hallucinogenic substance and may be responsible for schizophrenia and other mental illnesses. In what they called the "adrenochrome hypothesis", they speculated that megadoses of vitamin C and niacin could cure schizophrenia by reducing brain adrenochrome. There has been controversy about whether adrenochrome can be classified as a psychotropic drug.