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'''Saxitoxin''' ('''STX''') is a [[cyanotoxin]] found in marine dinoflagellates (algae). It is a [[neurotoxin]] that is a selective [[sodium channel]] blocker. The United States military isolated saxitoxin and assigned it the [[chemical weapon designation]] '''TZ'''. It is unique among [[toxin]]s in that it acts in a matter of minutes. The [[Median lethal dose|median lethal concentration]] (LCt<sub>50</sub>) of TZ is 5 mg·min/m³.
| C=10 | H=17 | N=7 | O=4
 
| cat =nd
 
| image =[[Image:Saxitoxin_structure.png|250px|Chemical structure of saxitoxin]]
 
| name =(3aS-(3a-&alpha;,4-&alpha;,10aR*))2,6-diamino-<br />4-(((amino-carbonyl)oxy)methyl)-3a,4,8,9-tetrahydro-<br />1H,10H-pyrrolo(1,2-c)purine-10,10-diol
 
| CAS =35523-89-8
 
| DrugBank =
 
| PubChem =37165
 
| SMILES =N=C1N[C@@H](COC(N)=O)[C@H]3[C@]<br />2(N=C(N)N3)N1CCC2(O)O
 
| mass =299.29
 
}}
 
   
'''Saxitoxin''' ('''STX''') is a [[cyanotoxin]] found in marine [[dinoflagellate]]s (algae). It is a [[neurotoxin]] that is a selective [[sodium channel]] blocker. The [[United States military]] isolated saxitoxin and assigned it the [[chemical weapon designation]] '''TZ'''. It is unique among [[toxin]]s in that it acts in a matter of minutes. The [[Median lethal dose|median lethal concentration]] (LCt<sub>50</sub>) of TZ is 5 [[milligram|mg]]·[[minute|min]]/[[cubic meter|m³]].
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The [[medical]] importance of saxitoxin is in relation to red tide in shellfish and causes the [[paralytic shellfish poisoning]] (PSP) [[food poisoning]]. The blocking of the sodium channel produces a flaccid paralysis that leaves its victim calm and conscious through the progression of [[symptom]]s. Death is from [[respiratory failure]].
 
The [[medical]] importance of saxitoxin is in relation to [[red tide]] in [[shellfish]] and causes the [[paralytic shellfish poisoning]] (PSP) [[food poisoning]]. The blocking of the sodium channel produces a flaccid paralysis that leaves its victim calm and conscious through the progression of [[symptom]]s. Death is from [[respiratory failure]].
 
   
 
It is listed in [[List of Schedule 1 substances (CWC)|schedule 1]] of the [[Chemical Weapons Convention]]. Though its early isolation and characterization were related to military efforts, saxitoxin has been more important to cellular research in delineating the function of the sodium channel.
 
It is listed in [[List of Schedule 1 substances (CWC)|schedule 1]] of the [[Chemical Weapons Convention]]. Though its early isolation and characterization were related to military efforts, saxitoxin has been more important to cellular research in delineating the function of the sodium channel.

Latest revision as of 19:08, March 31, 2008

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Saxitoxin (STX) is a cyanotoxin found in marine dinoflagellates (algae). It is a neurotoxin that is a selective sodium channel blocker. The United States military isolated saxitoxin and assigned it the chemical weapon designation TZ. It is unique among toxins in that it acts in a matter of minutes. The median lethal concentration (LCt50) of TZ is 5 mg·min/m³.

The medical importance of saxitoxin is in relation to red tide in shellfish and causes the paralytic shellfish poisoning (PSP) food poisoning. The blocking of the sodium channel produces a flaccid paralysis that leaves its victim calm and conscious through the progression of symptoms. Death is from respiratory failure.

It is listed in schedule 1 of the Chemical Weapons Convention. Though its early isolation and characterization were related to military efforts, saxitoxin has been more important to cellular research in delineating the function of the sodium channel.

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