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SCO-spondin is a protein that in humans is encoded by the SSPO gene.[1][2][3] SCO-spondin is secreted by the subcommissural organ, and contributes to commissural axon growth and the formation of Reissner's fiber, a fibrous aggregation of secreted molecules extending from the subcommissural organ to the end of the spinal cord.[4]


  1. Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A (Dec 1996). SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation. J Cell Sci ( Pt 5): 1053–61.
  2. Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A (Nov 2000). Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth. Glia 32 (2): 177–91.
  3. Entrez Gene: SSPO SCO-spondin homolog (Bos taurus).
  4. PMID 10197783 (PMID 10197783)
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Further readingEdit

  • Meiniel A, Meiniel R, Gonçalves-Mendes N, et al. (2004). The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines.. Int. Rev. Cytol. 230: 1–39.
  • Meiniel O, Meiniel A (2007). The complex multidomain organization of SCO-spondin protein is highly conserved in mammals.. Brain Research Reviews 53 (2): 321–7.
  • Nagase T, Ishikawa K, Miyajima N, et al. (1998). Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.. DNA Res. 5 (1): 31–9.
  • Nakayama M, Kikuno R, Ohara O (2003). Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.. Genome Res. 12 (11): 1773–84.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
  • Gonçalves-Mendes N, Simon-Chazottes D, Creveaux I, et al. (2003). Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain.. Gene 312: 263–70.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 (1): 40–5.
  • Gonçalves-Mendes N, Blanchon L, Meiniel A, et al. (2004). Placental expression of SCO-spondin during mouse and human development.. Gene Expr. Patterns 4 (3): 309–14.
  • Cheng J, Kapranov P, Drenkow J, et al. (2005). Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.. Science 308 (5725): 1149–54.

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