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Individual differences |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |
Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
The gene that encodes the serotonin transporter is called solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4).
There are a number of other names for this gene, e.g., in humans it may be referred to as hSERT. Other aliases are 5-HTT, 5HTT, HTT, OCD1 and SERT according to GeneCards.
Researchers have found an uncommon mutation in SLC6A4, in some unrelated families with OCD, that leads to faulty transporter function and regulation. A second variant in the same gene of some patients with this mutation suggests a genetic "double hit", resulting in greater biochemical effects and more severe symptoms.[How to reference and link to summary or text]
Noncoding polymorphisms Edit
The promotor region of the SLC6A4 gene contains a polymorphism with "short" and "long" repeats in a region: 5-HTT-linked polymorphic region (5-HTTLPR). The short variation leads to less transcription of SLC6A4, and it has been found that it can partly account for anxiety-related personality traits. This polymorphism has been extensively investigated in over 300 scientific studies (as of 2006)
References & BibliographyEdit
- ↑ Klaus-Peter Lesch, Dietmar Bengel, Armin Heils, Sue Z. Sabol, Benjamin D. Greenberg, Susanne Petri, Jonathan Benjamin, Clemens R. Müller, Dean H. Hamer, Dennis L. Murphy (November 1996). Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region. Science 274 (5292).
- ↑ J.R. Wendland, B.J. Martin, M.R. Kruse, K.-P. Lesch, D.L. Murphy (2006). Simultaneous genotyping of four functional loci of human SLCA4, with a reappraisal of 5-HTTLPR and rs255531. Molecular Psychiatry: 1-3.
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