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The nucleus reuniens, a component of the thalamic midline nuclear group, is located in the interthalamic adhesion (massa intermedia) in mammals.[1]

The nucleus reuniens receives afferent input from a large number of structures, mainly from limbic and limbic-associated structures.[2] It sends projections to the medial prefrontal cortex, the hippocampus, and the entorhinal cortex,[3][4] although there exist sparse connections to many of the afferent structures as well.[5] The frontal-hippocampal connection allows it to regulate the amount of neural traffic between them with changes in attentiveness,[6] as well as contribute to associative learning.[7]


  1. (1983) Human Neuroanatomy, 504-510, Baltimore: Williams & Wilkins.
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