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(Created page with "{{BioPsy}} Retrograde transneuronal degeneration is [[transneuronal degeneration caused by loss of [[Neural development#Neurotrophic factors|trophic]] support from the target....")
 
 
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{{BioPsy}}
 
{{BioPsy}}
Retrograde transneuronal degeneration is [[transneuronal degeneration caused by loss of [[Neural development#Neurotrophic factors|trophic]] support from the target. It occurs in presynaptic cells that are sending inputs to injured postsynaptic cells.<ref name="Pinching">{{cite journal |author=Pinching, A.J., and Powell, T.P. |title=Ultrastructural features of transneuronal degeneration in the olfactory system. |journal=J. Cell. Sci. |issue=8 |pages=253–287. |year=1971 |pmid=4101588 }}</ref> It is often termed "dying backward." This type of degeneration can be seen in [[Amyotrophic lateral sclerosis]]. Loss of [[Betz cell]]s is a variable effect of this disease but the loss of these cells in this disease demonstrates the “dying-back” ([[Polyneuropathy#Classification|axonopathy]]) due to the changes in upper motor neurons.<ref name="Eisen">{{cite journal |author=Eisen, Andrew, and Weber, Markus. |title=The Motor Cortex and Amyotrophic Lateral Sclerosis |journal=Muscle & Nerve |volume=24 |issue=4 |pages=564–573. |year=2001 |doi=10.1002/mus.1042 }}</ref>
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Retrograde transneuronal degeneration is [[transneuronal degeneration]] caused by loss of [[Neural development#Neurotrophic factors|trophic]] support from the target. It occurs in presynaptic cells that are sending inputs to injured postsynaptic cells.<ref name="Pinching">{{cite journal |author=Pinching, A.J., and Powell, T.P. |title=Ultrastructural features of transneuronal degeneration in the olfactory system. |journal=J. Cell. Sci. |issue=8 |pages=253–287. |year=1971 |pmid=4101588 }}</ref> It is often termed "dying backward." This type of degeneration can be seen in [[Amyotrophic lateral sclerosis]]. Loss of [[Betz cell]]s is a variable effect of this disease but the loss of these cells in this disease demonstrates the “dying-back” ([[Polyneuropathy#Classification|axonopathy]]) due to the changes in upper motor neurons.<ref name="Eisen">{{cite journal |author=Eisen, Andrew, and Weber, Markus. |title=The Motor Cortex and Amyotrophic Lateral Sclerosis |journal=Muscle & Nerve |volume=24 |issue=4 |pages=564–573. |year=2001 |doi=10.1002/mus.1042 }}</ref>
   
 
==See also==
 
==See also==

Latest revision as of 23:41, October 2, 2013

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Retrograde transneuronal degeneration is transneuronal degeneration caused by loss of trophic support from the target. It occurs in presynaptic cells that are sending inputs to injured postsynaptic cells.[1] It is often termed "dying backward." This type of degeneration can be seen in Amyotrophic lateral sclerosis. Loss of Betz cells is a variable effect of this disease but the loss of these cells in this disease demonstrates the “dying-back” (axonopathy) due to the changes in upper motor neurons.[2]

See alsoEdit

ReferencesEdit

  1. Pinching, A.J., and Powell, T.P. (1971). Ultrastructural features of transneuronal degeneration in the olfactory system.. J. Cell. Sci. (8): 253–287..
  2. Eisen, Andrew, and Weber, Markus. (2001). The Motor Cortex and Amyotrophic Lateral Sclerosis. Muscle & Nerve 24 (4): 564–573..

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