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Retrograde transneuronal degeneration is transneuronal degeneration caused by loss of trophic support from the target. It occurs in presynaptic cells that are sending inputs to injured postsynaptic cells.[1] It is often termed "dying backward." This type of degeneration can be seen in Amyotrophic lateral sclerosis. Loss of Betz cells is a variable effect of this disease but the loss of these cells in this disease demonstrates the “dying-back” (axonopathy) due to the changes in upper motor neurons.[2]

See alsoEdit


  1. Pinching, A.J., and Powell, T.P. (1971). Ultrastructural features of transneuronal degeneration in the olfactory system.. J. Cell. Sci. (8): 253–287..
  2. Eisen, Andrew, and Weber, Markus. (2001). The Motor Cortex and Amyotrophic Lateral Sclerosis. Muscle & Nerve 24 (4): 564–573..

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