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{{Infobox_Disease |
{{DiseaseDisorder infobox |
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Name = Restless legs syndrome |
Name = Restless legs syndrome |
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Image = |
ICD10 = G25.8 |
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Caption = |
ICD9 = {{ICD9|333.99}} |
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DiseasesDB = 29476 |
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ICD10 = {{ICD10|G|25|8|g|20}} |
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ICD9 = {{ICD9|333.99}} |
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ICDO = |
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OMIM = 102300 |
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OMIM_mult = {{OMIM2|608831}} |
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MedlinePlus = |
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eMedicineSubj = neuro |
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eMedicineTopic = 509 |
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MeshID = D012148 |
 
}}
 
}}
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'''Restless legs syndrome''' (RLS, or Wittmaack-Ekbom's syndrome) is poorly understood, often [[misdiagnosis|misdiagnosed]], and believed to be a [[neurological disorder]]. It is sometimes called "Ekbom's syndrome", however care should be used when using that term, as a distinct condition shares that same eponym: [[delusional parasitosis]].
   
'''Restless legs syndrome''' (RLS, or Wittmaack-Ekbom's syndrome, which is not to be confused with [[Ekbom's syndrome]]) is a poorly understood and often [[misdiagnosis|misdiagnosed]] [[neurological disorder]].
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== Explanation ==
   
== Description ==
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RLS (which is also sometimes referred to as [[Nocturnal myoclonus|Jimmy Legs]], The Orchestra, spare legs, "the kicks" or sewing machine foot) may be described as uncontrollable urges to move the limbs in order to stop uncomfortable, painful or odd sensations in the body, most commonly in the legs. Moving the affected body part modulates the sensations, providing temporary relief.
   
RLS may be described as uncontrollable urges to move the limbs in order to stop uncomfortable, painful or odd sensations in the body, most commonly in the legs. Moving the affected body part eliminates the sensation, providing temporary relief. The sensations and need to move may return immediately after ceasing movement, or at a later time. RLS may start at any age, including early childhood, and is a progressive disease for a certain percentage of sufferers, although it has been known for the symptoms to disappear permanently in some sufferers.
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The sensations and need to move may return immediately after ceasing movement, or at a later time. RLS may start at any age, including early childhood, and is a progressive disease for a certain portion of those afflicted, although the symptoms have disappeared permanently in some sufferers.
   
=== Symptoms ===
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== Symptoms ==
The International Restless Legs Syndrome Study Group (IRLSSG) identified four criteria that must be present for an RLS diagnosis.
 
   
 
*"An urge to move, usually due to uncomfortable sensations that occur primarily in the legs."
 
*"An urge to move, usually due to uncomfortable sensations that occur primarily in the legs."
The sensations are unusual and unlike other common sensation and those with RLS have a hard time describing them. People use words such as: uncomfortable, electrical, creeping, painful, itching, pins and needles, pulling, creepy-crawly, ants inside the legs, and many others. The sensation and the urge can occur in any body part; the most cited location is legs, followed by arms. Some people have little or no sensation, yet still have a strong urge to move.
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The sensations are unusual and unlike other common sensations, and those with RLS have a hard time describing them. People use words such as: uncomfortable, antsy, electrical, creeping, painful, itching, pins and needles, pulling, creepy-crawly, ants inside the legs, and many others. The sensation and the urge can occur in any body part; the most cited location is legs, followed by arms. Some people have little or no sensation, yet still have a strong urge to move.
   
 
*"Motor restlessness, expressed as activity, that relieves the urge to move."
 
*"Motor restlessness, expressed as activity, that relieves the urge to move."
   
Movement will usually bring immediate however often temporary relief. Walking is most common, however doing stretches, yoga, biking, or other physical activity may relieve the symptoms. Constant and fast up-and-down movement of the leg, coined "sewing machine legs" by at least one RLS sufferer, is often done to keep the sensations at bay without having to walk. Sometimes a specific type of movement will help a person more than another.
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Movement will usually bring immediate relief, however, often only temporary and partial. Walking is most common; however, doing stretches, yoga, biking, or other physical activity may relieve the symptoms. Constant and fast up-and-down movement of the leg, coined "sewing machine legs" by at least one RLS sufferer, is often done to keep the sensations at bay without having to walk. Sometimes a specific type of movement will help a person more than another.
   
 
*"Worsening of symptoms by relaxation."
 
*"Worsening of symptoms by relaxation."
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Any type of inactivity involving sitting or lying – reading a book, a plane ride, watching TV or a movie, taking a nap - can trigger the sensations and urge to move. This depends on several factors: the severity of the person’s RLS, the degree of restfulness, the duration of the inactivity, etc.
 
Any type of inactivity involving sitting or lying – reading a book, a plane ride, watching TV or a movie, taking a nap - can trigger the sensations and urge to move. This depends on several factors: the severity of the person’s RLS, the degree of restfulness, the duration of the inactivity, etc.
   
*"Variability over the course of the day-night cycle, with symptoms worse in the evening and early in the night."
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*"Variability over the course of the day-night cycle, with symptoms worse in the evening and early in the night."
   
While some people only experience RLS at bedtime and others experience it all day and all night, all sufferers notice that the RLS is worst in the evening and the least noticeable sometime in the early to mid morning.
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While some only experience RLS at bedtime and others experience it throughout the day and night, most sufferers experience the worst symptoms in the evening and the least in the morning.
   
== Prevalence ==
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===NIH criteria===
Often sufferers think they are the only ones to be afflicted by this peculiar condition and are relieved when they find out that many others also suffer from it. The severity and frequency of the disorder vary tremendously. Many people only experience symptoms when they try to sleep, while other experience symptoms during the day. It is common to have symptoms on long car rides or during any long period of inactivity (like watching television or a movie, attending a musical or theatrical performance, etc.) Approximately 80-90% of people with RLS also have PLMD, Periodic Limb Movement Disorder, which causes slow "jerks" or flexions of the affected body part. These occur during sleep (PLMS = Periodic Limb Movement while Sleeping) or while awake (PLMW - Periodic Limb Movement while Waking).
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In 2003 National Institutes of Health (NIH) consensus panel modified their criteria in to include the following:
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* (1) an urge to move the limbs with or without sensations
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* (2) worsening at rest
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* (3) improvement with activity
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* (4) worsening in the evening or night.<ref>{{cite journal | author = Allen R, Picchietti D, Hening W, Trenkwalder C, Walters A, Montplaisi J | title = Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. | journal = Sleep Med | volume = 4 | issue = 2 | pages = 101-19 | year = 2003 | id = PMID 14592341}}</ref>
   
About 10 percent of adults in North America and Europe may experience RLS symptoms, according to the National Sleep Foundation, which reports that "lower prevalence has been found in [[India]], [[Japan]] and [[Singapore]]," indicating that [[Ethnic group|ethnic]] factors, including diet, may play a role in the prevalence of this syndrome. [http://www.sleepfoundation.org/sleeplibrary/index.php?id=66]
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== Incidence/Prevalence ==
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Restless Leg Syndrome affects an estimated 2.7% of the general population in the U.S.A..<ref name="allen2005">{{cite journal | author=Allen RP, Walters AS, Montlplaisir J, et al.| title=Restless legs syndrome prevalence and impact.| journal=Arch Int Med| year=2005| volume=165| pages=1286-1292}}</ref>
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Often sufferers think they are the only ones to be afflicted by this peculiar condition and are relieved when they find out that many others also suffer from it. The severity and frequency of the disorder vary tremendously. Many people only experience symptoms when they try to sleep, while other experience symptoms during the day. It is common to have symptoms on long car rides or during any long period of inactivity (like watching television or a movie, attending a musical or theatrical performance, etc.) Approximately 80-90% of people with RLS also have PLMD, [[Nocturnal myoclonus|Periodic Limb Movement Disorder]], which causes slow "jerks" or flexions of the affected body part. These occur during sleep (PLMS = Periodic Limb Movement while Sleeping) or while awake (PLMW - Periodic Limb Movement while Waking).
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About 10 percent of adults in North America and Europe may experience RLS symptoms, according to the National Sleep Foundation, which reports that "lower prevalence has been found in India, Japan and Singapore," indicating that [[Ethnic group|ethnic]] factors, including diet, may play a role in the prevalence of this syndrome. <ref>http://www.sleepfoundation.org/sleeplibrary/index.php?id=66</ref>
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== History ==
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The Restless legs syndrome is also known as the Ekbom syndrome, the Wittmaack-Ekbom syndrome, or anxietas tibialis.
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In a 1945 publication titled 'Restless Legs', Karl-Axel Ekbom described the disease and presented eight cases used for his studies.<ref>Ekbom, K.-A. Restless legs: a clinical study. Acta Med. Scand. (Suppl.) 158: 1-123, 1945.</ref>
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Earlier studies were done by Thomas Willis (1622-1675) and by Theodor Wittmaack. Another early description of the disease and its symptoms were made by George Miller Beard (1839-1883).
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== Types ==
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RLS is either primary or secondary.
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* Primary RLS is considered [[idiopathic]], or with no known cause. Primary RLS usually begins before age 40 or 45, and can even occur as early as the first year of life. In primary RLS, the onset is often slow. The RLS may disappear for months, or even years. It is often progressive and gets worse as the person ages. RLS in children is often misdiagnosed as [[growing pains]].
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* Secondary RLS often had a sudden onset and may be daily from the very beginning. It often occurs after the age of 40, however it can occur earlier. It is most associated with specific medical conditions or the use of certain drugs. The most commonly associated medical condition is [[iron deficiency (medicine)]], which accounts for just over 20% of all cases of RLS. The conditions include: pregnancy, [[varicose vein]] or venous reflux , [[folate deficiency]], [[uremia]], [[diabetes mellitus|diabetes]], thyroid problems, peripheral neuropathy, [[Parkinson's disease]] and certain auto-immune disorders such as [[Sjögren's syndrome]], [[Celiac Disease]], and [[rheumatoid arthritis]]. Treatment of the underlying condition often eliminates the RLS.
   
 
== Causes ==
 
== Causes ==
RLS is either primary or secondary. Primary RLS is considered [[idiopathic]], or with no known cause. However, there is a high incidence of familial cases, suggesting a [[genetics|genetic]] tendency in primary RLS. Primary RLS starts before age 40 or 45 (can occur as early as the first year of life). In primary RLS, the onset is often slow. The RLS may disappear for months, or even years, however it always returns. It is often progressive and gets worse as the person ages.
 
   
Secondary RLS often had a sudden onset and may be daily from the very beginning. It often occurs after the age of 40, however it can occur earlier. It is most associated with specific medical conditions or the use of certain drugs. The conditions include: pregnancy, iron deficiency, folate deficiency, uremia, diabetes, thyroid problems, peripheral neuropathy, and certain auto-immune disorders such as Sjogren's, Celiac Disease, and rheumatoid arthritis. Treatment of the underlying condition often eliminates the RLS.
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Certain medications may worsen RLS in those who already have it, or cause it secondarily. These include: [[anti-nausea drugs]], certain [[antihistamines]] (often in [[over-the-counter]] cold medications), [[antidepressants|drugs used to treat depression]] (both older [[tricyclics]] and newer [[SSRI]]s), [[antipsychotic]] drugs, and certain medications used to control [[seizures]]. Some people find it is worsened by the consumption of [[diet soda]], [[alcohol]], or [[caffeine]]. [[Hypoglycemia]] has also been found to worsen RLS symptoms. For those affected, a reduction or elimination in the consumption of simple carbohydrates (for example, sugar, white flour, white rice and white potatoes) is recommended.
   
Both primary and secondary RLS can be worsened by surgery of any kind, however back surgery or injury is often associated with causing RLS.
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Both primary and secondary RLS can be worsened by surgery of any kind, however [[back surgery]] or injury is often associated with causing RLS. RLS often worsens in [[pregnancy]].
   
Certain medications may worsen RLS in those who already have it, or cause it secondarily. These include: anti-nausea drugs, certain antihistamines (often in over-the-counter cold medications), drugs used to treat depression (both older tricyclics and newer SSRIs), antipsychotic drugs, and certain medications used to control seizures.
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===Genetics===
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40% of cases of RLS are familial and are inherited in an [[autosomal dominant]] fashion with [[variable penetrance]].
   
Train drivers in [[South Africa]] operate a [[vigilance control]] by clicking a pedal with their right foot every thirty seconds. If it doesn't happen, a stimulus is emitted followed soon by emergency braking, it can contribute to restless legs syndrome which can keep the driver clicking the pedal while sleeping.{{citation needed}}
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No one knows the exact cause of RLS at present. Research and brain autopsies have implicated both dopaminergic system and iron insufficiency in the [[substantia nigra]] (study published in Neurology, 2003).<ref>{{cite journal | author = Connor J, Boyer P, Menzies S, Dellinger B, Allen R, Ondo W, Earley C | title = Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. | journal = Neurology | volume = 61 | issue = 3 | pages = 304-9 | year = 2003 | id = PMID 12913188}}</ref> Iron is an essential cofactor for the formation of L-dopa, the precursor of dopamine. An Icelandic study in 2005 confirmed the presence of an RLS susceptibility gene also found previously in a smaller French-Canadian population.<ref>{{cite journal | author = Desautels A, Turecki G, Montplaisir J, Sequeira A, Verner A, Rouleau G | title = Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q. | journal = Am J Hum Genet | volume = 69 | issue = 6 | pages = 1266-70 | year = 2001 | id = PMID 11704926}}</ref><ref>{{cite journal | author = Levchenko A, Montplaisir J, Dubé M, Riviere J, St-Onge J, Turecki G, Xiong L, Thibodeau P, Desautels A, Verlaan D, Rouleau G | title = The 14q restless legs syndrome locus in the French Canadian population. | journal = Ann Neurol | volume = 55 | issue = 6 | pages = 887-91 | year = 2004 | id = PMID 15174026}}</ref>
   
 
== Treatment ==
 
== Treatment ==
An algorithm for treating RLS was created by leading RLS researchers at the [[Mayo Clinic]] and is endorsed by the Restless Legs Syndrome Foundation. This document provides guidance to both the treating physician and the patient, and includes both nonpharmacological and pharmacological treatments.
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An algorithm for treating Primary RLS ( RLS without any secondary medical condition including [[Iron deficiency]] , [[varicose vein]] , [[thyroid]], etc ) was created by leading RLS researchers at the [[Mayo Clinic]] and is endorsed by the Restless Legs Syndrome Foundation. This document provides guidance to both the treating physician and the patient, and includes both nonpharmacological and pharmacological treatments.<ref>[http://www.mayoclinicproceedings.com/inside.asp?AID=744&UID Mayo Clinic Algorithm] also available [http://www.mayo.edu/proceedings/2004/jul/7907crc.pdf as .pdf]</ref> Treatment of primary RLS should not be considered unless all the secondary medical conditions are ruled out. Drug therapy in RLS is not curative and is known to have significant side effects and needs to be considered with caution. The secondary form of RLS has the potential for cure if the precipitating medical condition ([[iron deficiency]], venous reflux/[[varicose vein]], [[thyroid]], etc.) is managed effectively.
   
Treatment for RLS is based on how disruptive the symptoms are. All people should review their lifestyle and see what changes could be made to reduce or eliminate their RLS symptoms. These include: finding the right level of exercise (too much worsens it, too little may trigger it); eliminating caffeine, smoking, and alcohol; changing the diet to eliminate foods that trigger RLS (different for each person, but may include eliminating sugar, triglycerides, gluten, sugar substitutes, following a low-fat diet, etc.); keeping good sleep hygiene; treating conditions that may cause secondary RLS; avoiding or stopping OTC or prescription drugs that trigger RLS; adding supplements such as magnesium, B-12, folate, vitamin E, and calcium. Some of these changes, such as diet and adding supplements are based on anecdotal evidence from RLS sufferers, as few studies have been done on these alternatives.
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===Iron supplements===
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All people with RLS should have their [[ferritin]] levels tested; ferritin levels should be at least 50 mcg for those with RLS. Oral iron supplements, taken under a doctor's care, can increase ferritin levels. For some people, increasing ferritin will eliminate or reduce RLS symptoms. A ferritin level of 50 mcg is not sufficient for some sufferers and increasing the level to 80 mcg may greatly reduce symptoms. However, at least 40% of people will not notice any improvement. Treatment with IV iron is being tested at the US [[Mayo Clinic]] and [[John Hopkins Hospital]]. It is dangerous to take iron supplements without first having ferritin levels tested, as many people with RLS do not have low ferritin and taking iron when it is not called for can cause [[hemochromatosis]], a very dangerous condition.
   
All people with RLS should have their [[ferritin]] levels tested; ferritin levels should be at least 50 mcg for those with RLS. Oral iron supplements, taken under a doctor's care, can increase ferritin levels. For some people, increasing ferritin will eliminate or reduce RLS symptoms. At least 40% of people will not notice any improvement, however. IV iron is being tested at the US [[Mayo Clinic]] as a method of treating RLS. It is dangerous to take iron supplements without first having ferritin levels tested, as many people with RLS do not have low ferritin and excess iron in the body can cause [[hemochromatosis]], a very dangerous condition.
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===Lifestyle changes and other non-medicinal approaches===
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Treatment for RLS is based on how disruptive the symptoms are. All people should review their lifestyle and see what changes could be made to reduce or eliminate their RLS symptoms. These include: finding the right level of [[exercise]] (too much worsens it, too little may trigger it); eliminating [[caffeine]], [[smoking]], and [[alcohol]]; changing the diet to eliminate foods that trigger RLS (different for each person, but may include eliminating [[sugar]], [[triglycerides]], [[gluten]], sugar substitutes ([[aspartame]]), following a [[low-fat diet]], etc.); keeping good [[sleep hygiene]]; treating conditions that may cause secondary RLS; avoiding or stopping OTC or prescription drugs that trigger RLS; adding supplements such as [[potassium]], [[magnesium]], [[B-12]], [[folate]], [[vitamin E]], and [[calcium]]. Some of these changes, such as diet (particularly aspartame) and adding supplements are based on anecdotal evidence from RLS sufferers as few studies have been done on these alternatives.
   
 
For those who experience RLS infrequently and do not need or want to try medication, in addition to lifestyle changes they can try:
 
For those who experience RLS infrequently and do not need or want to try medication, in addition to lifestyle changes they can try:
* some form of exercise for several minutes such as walking, stretching, yoga, etc. at bedtime
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* some form of exercise for several minutes such as walking, stretching, meditation, [[yoga]], etc. at bedtime
 
* heat or cold, such as a hot or cold bath, a heating pad, or a fan
 
* heat or cold, such as a hot or cold bath, a heating pad, or a fan
* engrossing the mind into a game, the computer, or figuring something out
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* soaking one's feet in hot water just prior to going to sleep
* wearing compression stockings, tight pantyhose, or wrapping the legs in ace bandages
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* engrossing the mind in a game, the [[computer]], or figuring something out
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* wearing [[compression stockings]], tight [[pantyhose]], or wrapping the legs in [[ace bandages]]
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* placing a pillow between the knees or upper-legs while lying in bed
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* hot green tea can relieve symptoms
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* vigorous, deep breathing for one or two minutes
   
For those whose RLS disrupts or prevents sleep or regular daily activities, medication is often required. Doctors currently use, and the [[Mayo Clinic]] [[Algorithm]] includes, medication from four categories:
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===Medicinal approaches===
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For those whose RLS disrupts or prevents sleep or regular daily activities, medication is often required. Many Doctors currently use, and the [[Mayo Clinic]] [[Algorithm]] includes, medication from four categories:
   
 
* [[Dopamine agonist]]s such as [[ropinirole]], [[pramipexole]], [[carbidopa]]/[[levodopa]] or [[pergolide]]
 
* [[Dopamine agonist]]s such as [[ropinirole]], [[pramipexole]], [[carbidopa]]/[[levodopa]] or [[pergolide]]
* [[Opioid]]s such as [[propoxyphene]], [[oxycodone]], or [[methadone]]
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** In 2005, The Food and Drug Administration approved [[ropinirole]] to treat moderate to severe Restless Legs Syndrome (RLS). The drug was first approved for [[Parkinson's disease]] in 1997.
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** In February 2006, the EU Scientific Committee issued a positive recommendation for approving [[pramipexole]] (Mirapex, Sifrol, Mirapexen in the EU) for the treatment of RLS in the EU. US FDA approved Mirapex in 2006.
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** Another dopamine agonist, [[rotigotine]] delivered via a transdermal patch, is currently in process for US FDA and EU approval for RLS.
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** Dopamine agonists may cause augmentation. This is a medical condition where the drug itself causes symptoms to increase in severity and/or occur earlier in the day. Dopamine agonists may also cause rebound, when symptoms increase as the drug wears off.
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* [[Opioid]]s such as [[propoxyphene]], [[oxycodone]], or [[methadone]], etc.
 
* [[Benzodiazepine]]s, which often assist in staying asleep and reducing awakenings from the movements
 
* [[Benzodiazepine]]s, which often assist in staying asleep and reducing awakenings from the movements
* [[Anticonvulsant]]s, which often help people who experience the RLS sensations as painful, such as [[gabapentin]]
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* [[Anticonvulsant]]s, which often help people who experience the RLS sensations as painful, such as [[gabapentin]]
   
There is also strong anecdotal evidence that [[medical marijuana]] alleviates RLS, although studies are lacking because of governmental restrictions.
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Other medicinal approaches include the following:
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* There is also anecdotal evidence that [[medical marijuana]] alleviates RLS, although studies are lacking because of governmental restrictions.{{Fact|date=February 2007}}
   
In 2005, The Food and Drug Administration approved [[ropinirole]] to treat moderate to severe Restless Legs Syndrome (RLS). The drug was first approved for [[Parkinson's disease]] in 1997. In February 2006, the EU Scientific Committee issued a positive recommendation for approving pramipexole (Sifrol, Mirapexen in the EU) for the treatment of RLS in the EU. US FDA approval is expected sometime in 2006. Another dopamine agonist, rotigitine delivered via a transdermal patch, is currently in process for US FDA and EU approval for RLS.
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* Some people have reported partial or even complete relief with taking a supplemental magnesium salt such as '''[[magnesium oxide]]''' or [[magnesium gluconate]] once or twice a day, backing off on the dose if [[diarrhea]] develops. Magnesium sulfate is the most active form; however, anyone with renal problems should stay away from magnesium supplements.
 
Dopamine agonists may cause augmentation. This is a medical condition where the drug itself causes symptoms to increase in severity and/or occur earlier in the day. Dopamine agonists may also may cause rebound, when symptoms increase as the drug wears off.
 
 
==Theories regarding RLS ==
 
 
No one knows the exact cause of RLS at present. Research and brain autopsies have implicated both dopaminergic system and iron insufficiency in the substantia nigra (study published in Neurology, 2003). Iron is involved in the formation of dopamine. An Icelandic study in 2005 confirmed the presence of an RLS susceptibility gene also found previously in a smaller French-Canadian population in 2003.
 
 
The continual-activation theory of restless legs syndrome proposed by Jie Zhang hypothesizes that RLS occurs when a brain mechanism which is evolved for safeguard brain from "brain death" during sleep, is wrongly turned on during waking time. The theory is developed through a series of hypotheses. Zhang believes that human brain can be divided into two subsidiary systems: the conscious brain and the non-conscious brain. The conscious subsidiary system of brain is evolved to process conscious related human information like declarative memory for instance, while the non-conscious subsidiary system is evolved to process non-conscious related information such as procedural memory and motor skills. In order to maintain brain proper functioning, Zhang proposes that both systems have to be continually activated through their life times. To carry out this task, Zhang suggests that human brain has a continual-activation mechanism in each subsidiary system. When the level of activation in any subsidiary system descends to a given threshold, the corresponding continual-activation mechanism will be triggered to generate a pulse-like activation signal. According to this theory, the continual-activation mechanism in the non-conscious part of brain is supposed to be turned on during NREM sleep; while the continual-activation mechanism in the conscious part of brain is supposed to be switched on during REM sleep. RLS occurs when the continual-activation mechanism in the non-conscious subsidiary system of brain is wrongly triggered during waking, due to the malfunction of continual-activation thresholds. The theory also predicts that a close related illness - PLMD (periodic limb movement disorder) is sprung from the same mechanism, but with different cause. PLMD occurs when the lowered muscle tone is lacking while this mechanism is activated during NREM sleep. (Zhang, 2005a & 2005b).
 
   
 
==See also ==
 
==See also ==
 
*[[Actigraphy]]
 
*[[Actigraphy]]
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*[[Parasomnia]]
   
 
==External links==
 
==External links==
*[http://p4.forumforfree.com/restless-legs-syndrome-vf5-parkinsons.html Restless legs syndrome - new research, news reports, new books, web sites]
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*[http://www.sleepdisordersguide.com/restless-leg-syndrome.html All about Restless legs Syndrome at sleepdisordersguide.com]
*[http://www.sleepeducation.com Everything you wanted to know about sleep and sleep disorders]
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* [http://www.rls.org/ Restless Legs Syndrome Foundation - rls.org]
*[http://www.aasmnet.org American Academy of Sleep Medicine]
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* {{NINDS|restless_legs}}
*[http://www.sleepdisordersguide.com/restless-leg-syndrome.html All about Restless legs Syndrome]
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* [http://www.restlesslegsyndrome.com Restless Legs Syndrome Symptoms & Sleep info]
*[http://www.sleepcenters.org Find an accredited sleep center]
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* {{Medicinenet|restless_leg_syndrome}}
*[http://www.sleepresearchsociety.org Sleep Research Society]
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* [http://www.helpguide.org/aging/restless_leg_syndrome_rls.htm Restless Legs Syndrome (RLS) and Periodic Limb Movements in Sleep (PLMS): Symptoms, Causes, Diagnosis, and Treatment at helpguide.org]
* [http://www.rls.org/ Restless Legs Syndrome Foundation]
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* [http://www.neuro.jhmi.edu/rls/aboutus.htm Johns Hopkins Center for RLS], [http://www.neuro.jhmi.edu/rls/edu.htm education]
* [http://www.restlesslegsyndrome.com/ Restless Leg Syndrome Forum/Treatment Options]
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* [http://www.restlesslegsreport.com Restless Legs Syndrome Symptoms & Information at restlesslegsreport.com]
* [http://goldbamboo.com/topic-t1694.html Clinical and alternative outlook for RLS]
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* [http://www.restlesslegs.org.uk RLS:UK]
* [http://www.ninds.nih.gov/disorders/restless_legs/restless_legs.htm Restless Legs Syndrome factsheet from the National Institutes of Health]
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* [http://www.sleepfoundation.org/sleeptionary/index.php?id=23 Restless Legs Syndrome in the National Sleep Foundation "Sleeptionary"]
* [http://www.restless-legs-syndrome.info Restless Legs Syndrome Symptoms & Treatments]
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* [http://health.ivillage.com/quicklinks_sleepdisorders/0,,b6fj76m5,00.html Restless Leg Syndrome Treatment, Diagnosis, and Symptoms]
* [http://www.medicinenet.com/Script/Main/Art.asp?li=MNI&ArticleKey=1972 RLS overview from MedicineNet]
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*[http://dx.doi.org/10.1371/journal.pmed.0030170 Woloshin S, Schwartz LM (2006) Giving Legs to Restless Legs: A Case Study of How the Media Helps Make People Sick. PLoS Med 3(4): e170 doi:10.1371/journal.pmed.0030170] Restless legs as “Disease mongering”.
* [http://www.helpguide.org/aging/restless_leg_syndrome_rls.htm Restless Legs Syndrome (RLS) and Periodic Limb Movements in Sleep (PLMS): Symptoms, Causes, Diagnosis, and Treatment]
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* [http://www.mayoclinicproceedings.com/inside.asp?AID=744&UID Mayo Clinic Algorithm] also available [http://www.mayo.edu/proceedings/2004/jul/7907crc.pdf as .pdf]
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==References==
* [http://restless-leg-syndrome.blogspot.com Restless Leg Syndrome]
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<references/>
* Sleep Education site from American Academy of Sleep Medicine [http://www.sleepeducation.com/index.aspx]
 
* John Hopkins Center for RLS http://www.neuro.jhmi.edu/rls/aboutus.htm
 
   
 
==Sources==
 
==Sources==
* Ekbom KA. Restless legs syndrome. ''Neurology'' 1960;10:868–73. PMID 13726241.
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* {{cite journal | author = Medcalf P, Bhatia K | title = Restless legs syndrome. | journal = BMJ | volume = 333 | issue = 7566 | pages = 457-8 | year = 2006 | id = PMID 16946320}} Competing interests: KB has been reimbursed by GSK Ltd for attending a neurology conference and has received honorariums for speaking at an educational programme. PM has received educational grants to attend international meetings on movement disorders.
* [http://www.msnbc.msn.com/id/7475344/ Study: Restless leg syndrome runs in families - General Health - MSNBC.com]
 
* http://www.absm.org/Diplomates/listing.htm - A worldwide listing of doctors cetified by the American Board of Sleep Medicine
 
* [Restless Legs Syndrome Online Forum/TreatmentOptions Restless Legs Syndrome.com]
 
 
* {{cite news | title=Treatment of restless legs syndrome | date=2005;21(6):210606 | publisher=Pharmacist's Letter/Prescriber's Letter | url=http://www.pharmacistsletter.com}}
 
* {{cite news | title=Treatment of restless legs syndrome | date=2005;21(6):210606 | publisher=Pharmacist's Letter/Prescriber's Letter | url=http://www.pharmacistsletter.com}}
 
* MD Virtual University http://www.mdvu.org/library/disease/rls/
 
* MD Virtual University http://www.mdvu.org/library/disease/rls/
* The RLS Rebel http://members.cox.net/gunzel/rls.html
 
* John Hopkins Center for RLS Education http://www.neuro.jhmi.edu/rls/edu.htm
 
 
* The International Restless Legs Study Group http://www.irlssg.org/
 
* The International Restless Legs Study Group http://www.irlssg.org/
* We Move http://www.wemove.org/
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* Schul M, McDonagh B, Guptan RC [http://www.veinclinics.com/5research_6.html High Prevalence Of Restless Leg syndrome In Patients With Chronic Venous Insufficiency: A Story Untold]
* Zhang, Jie (2005a) [http://www.goertzel.org/dynapsyc/2005/ZhangDreams.htm Continual-activation theory of dreaming], Dynamical Psychology.
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* {{WhoNamedIt|synd|2337}}
* Zhang, Jie (2005b) [http://www.goertzel.org/dynapsyc/2005/ZhangSZ.htm Continual-activation theories of schizophrenia and restless legs syndrome], Dynamical Psychology.
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* SLEEP THIEF, restless legs syndrome, by Virginia N. Wilson. 316 pages. Galaxy Books, Inc. ISBN 0965268209
* National Institutue of Neurological Disorders and Strokes - Restless Legs Syndrome Fact Sheet [http://www.ninds.nih.gov/disorders/restless_legs/detail_restless_legs.htm]
 
   
 
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{{enWP|Restless legs syndrome}}

Revision as of 22:39, March 9, 2007

Restless legs syndrome
ICD-10 G258
ICD-9 333.99
OMIM 102300 608831
DiseasesDB 29476
MedlinePlus [1]
eMedicine neuro/509
MeSH {{{MeshNumber}}}

Restless legs syndrome (RLS, or Wittmaack-Ekbom's syndrome) is poorly understood, often misdiagnosed, and believed to be a neurological disorder. It is sometimes called "Ekbom's syndrome", however care should be used when using that term, as a distinct condition shares that same eponym: delusional parasitosis.

Explanation

RLS (which is also sometimes referred to as Jimmy Legs, The Orchestra, spare legs, "the kicks" or sewing machine foot) may be described as uncontrollable urges to move the limbs in order to stop uncomfortable, painful or odd sensations in the body, most commonly in the legs. Moving the affected body part modulates the sensations, providing temporary relief.

The sensations and need to move may return immediately after ceasing movement, or at a later time. RLS may start at any age, including early childhood, and is a progressive disease for a certain portion of those afflicted, although the symptoms have disappeared permanently in some sufferers.

Symptoms

  • "An urge to move, usually due to uncomfortable sensations that occur primarily in the legs."

The sensations are unusual and unlike other common sensations, and those with RLS have a hard time describing them. People use words such as: uncomfortable, antsy, electrical, creeping, painful, itching, pins and needles, pulling, creepy-crawly, ants inside the legs, and many others. The sensation and the urge can occur in any body part; the most cited location is legs, followed by arms. Some people have little or no sensation, yet still have a strong urge to move.

  • "Motor restlessness, expressed as activity, that relieves the urge to move."

Movement will usually bring immediate relief, however, often only temporary and partial. Walking is most common; however, doing stretches, yoga, biking, or other physical activity may relieve the symptoms. Constant and fast up-and-down movement of the leg, coined "sewing machine legs" by at least one RLS sufferer, is often done to keep the sensations at bay without having to walk. Sometimes a specific type of movement will help a person more than another.

  • "Worsening of symptoms by relaxation."

Any type of inactivity involving sitting or lying – reading a book, a plane ride, watching TV or a movie, taking a nap - can trigger the sensations and urge to move. This depends on several factors: the severity of the person’s RLS, the degree of restfulness, the duration of the inactivity, etc.

  • "Variability over the course of the day-night cycle, with symptoms worse in the evening and early in the night."

While some only experience RLS at bedtime and others experience it throughout the day and night, most sufferers experience the worst symptoms in the evening and the least in the morning.

NIH criteria

In 2003 National Institutes of Health (NIH) consensus panel modified their criteria in to include the following:

  • (1) an urge to move the limbs with or without sensations
  • (2) worsening at rest
  • (3) improvement with activity
  • (4) worsening in the evening or night.[1]

Incidence/Prevalence

Restless Leg Syndrome affects an estimated 2.7% of the general population in the U.S.A..[2]

Often sufferers think they are the only ones to be afflicted by this peculiar condition and are relieved when they find out that many others also suffer from it. The severity and frequency of the disorder vary tremendously. Many people only experience symptoms when they try to sleep, while other experience symptoms during the day. It is common to have symptoms on long car rides or during any long period of inactivity (like watching television or a movie, attending a musical or theatrical performance, etc.) Approximately 80-90% of people with RLS also have PLMD, Periodic Limb Movement Disorder, which causes slow "jerks" or flexions of the affected body part. These occur during sleep (PLMS = Periodic Limb Movement while Sleeping) or while awake (PLMW - Periodic Limb Movement while Waking).

About 10 percent of adults in North America and Europe may experience RLS symptoms, according to the National Sleep Foundation, which reports that "lower prevalence has been found in India, Japan and Singapore," indicating that ethnic factors, including diet, may play a role in the prevalence of this syndrome. [3]

History

The Restless legs syndrome is also known as the Ekbom syndrome, the Wittmaack-Ekbom syndrome, or anxietas tibialis.

In a 1945 publication titled 'Restless Legs', Karl-Axel Ekbom described the disease and presented eight cases used for his studies.[4]

Earlier studies were done by Thomas Willis (1622-1675) and by Theodor Wittmaack. Another early description of the disease and its symptoms were made by George Miller Beard (1839-1883).

Types

RLS is either primary or secondary.

  • Primary RLS is considered idiopathic, or with no known cause. Primary RLS usually begins before age 40 or 45, and can even occur as early as the first year of life. In primary RLS, the onset is often slow. The RLS may disappear for months, or even years. It is often progressive and gets worse as the person ages. RLS in children is often misdiagnosed as growing pains.

Causes

Certain medications may worsen RLS in those who already have it, or cause it secondarily. These include: anti-nausea drugs, certain antihistamines (often in over-the-counter cold medications), drugs used to treat depression (both older tricyclics and newer SSRIs), antipsychotic drugs, and certain medications used to control seizures. Some people find it is worsened by the consumption of diet soda, alcohol, or caffeine. Hypoglycemia has also been found to worsen RLS symptoms. For those affected, a reduction or elimination in the consumption of simple carbohydrates (for example, sugar, white flour, white rice and white potatoes) is recommended.

Both primary and secondary RLS can be worsened by surgery of any kind, however back surgery or injury is often associated with causing RLS. RLS often worsens in pregnancy.

Genetics

40% of cases of RLS are familial and are inherited in an autosomal dominant fashion with variable penetrance.

No one knows the exact cause of RLS at present. Research and brain autopsies have implicated both dopaminergic system and iron insufficiency in the substantia nigra (study published in Neurology, 2003).[5] Iron is an essential cofactor for the formation of L-dopa, the precursor of dopamine. An Icelandic study in 2005 confirmed the presence of an RLS susceptibility gene also found previously in a smaller French-Canadian population.[6][7]

Treatment

An algorithm for treating Primary RLS ( RLS without any secondary medical condition including Iron deficiency , varicose vein , thyroid, etc ) was created by leading RLS researchers at the Mayo Clinic and is endorsed by the Restless Legs Syndrome Foundation. This document provides guidance to both the treating physician and the patient, and includes both nonpharmacological and pharmacological treatments.[8] Treatment of primary RLS should not be considered unless all the secondary medical conditions are ruled out. Drug therapy in RLS is not curative and is known to have significant side effects and needs to be considered with caution. The secondary form of RLS has the potential for cure if the precipitating medical condition (iron deficiency, venous reflux/varicose vein, thyroid, etc.) is managed effectively.

Iron supplements

All people with RLS should have their ferritin levels tested; ferritin levels should be at least 50 mcg for those with RLS. Oral iron supplements, taken under a doctor's care, can increase ferritin levels. For some people, increasing ferritin will eliminate or reduce RLS symptoms. A ferritin level of 50 mcg is not sufficient for some sufferers and increasing the level to 80 mcg may greatly reduce symptoms. However, at least 40% of people will not notice any improvement. Treatment with IV iron is being tested at the US Mayo Clinic and John Hopkins Hospital. It is dangerous to take iron supplements without first having ferritin levels tested, as many people with RLS do not have low ferritin and taking iron when it is not called for can cause hemochromatosis, a very dangerous condition.

Lifestyle changes and other non-medicinal approaches

Treatment for RLS is based on how disruptive the symptoms are. All people should review their lifestyle and see what changes could be made to reduce or eliminate their RLS symptoms. These include: finding the right level of exercise (too much worsens it, too little may trigger it); eliminating caffeine, smoking, and alcohol; changing the diet to eliminate foods that trigger RLS (different for each person, but may include eliminating sugar, triglycerides, gluten, sugar substitutes (aspartame), following a low-fat diet, etc.); keeping good sleep hygiene; treating conditions that may cause secondary RLS; avoiding or stopping OTC or prescription drugs that trigger RLS; adding supplements such as potassium, magnesium, B-12, folate, vitamin E, and calcium. Some of these changes, such as diet (particularly aspartame) and adding supplements are based on anecdotal evidence from RLS sufferers as few studies have been done on these alternatives.

For those who experience RLS infrequently and do not need or want to try medication, in addition to lifestyle changes they can try:

  • some form of exercise for several minutes such as walking, stretching, meditation, yoga, etc. at bedtime
  • heat or cold, such as a hot or cold bath, a heating pad, or a fan
  • soaking one's feet in hot water just prior to going to sleep
  • engrossing the mind in a game, the computer, or figuring something out
  • wearing compression stockings, tight pantyhose, or wrapping the legs in ace bandages
  • placing a pillow between the knees or upper-legs while lying in bed
  • hot green tea can relieve symptoms
  • vigorous, deep breathing for one or two minutes

Medicinal approaches

For those whose RLS disrupts or prevents sleep or regular daily activities, medication is often required. Many Doctors currently use, and the Mayo Clinic Algorithm includes, medication from four categories:

  • Dopamine agonists such as ropinirole, pramipexole, carbidopa/levodopa or pergolide
    • In 2005, The Food and Drug Administration approved ropinirole to treat moderate to severe Restless Legs Syndrome (RLS). The drug was first approved for Parkinson's disease in 1997.
    • In February 2006, the EU Scientific Committee issued a positive recommendation for approving pramipexole (Mirapex, Sifrol, Mirapexen in the EU) for the treatment of RLS in the EU. US FDA approved Mirapex in 2006.
    • Another dopamine agonist, rotigotine delivered via a transdermal patch, is currently in process for US FDA and EU approval for RLS.
    • Dopamine agonists may cause augmentation. This is a medical condition where the drug itself causes symptoms to increase in severity and/or occur earlier in the day. Dopamine agonists may also cause rebound, when symptoms increase as the drug wears off.
  • Opioids such as propoxyphene, oxycodone, or methadone, etc.
  • Benzodiazepines, which often assist in staying asleep and reducing awakenings from the movements
  • Anticonvulsants, which often help people who experience the RLS sensations as painful, such as gabapentin

Other medicinal approaches include the following:

  • Some people have reported partial or even complete relief with taking a supplemental magnesium salt such as magnesium oxide or magnesium gluconate once or twice a day, backing off on the dose if diarrhea develops. Magnesium sulfate is the most active form; however, anyone with renal problems should stay away from magnesium supplements.

See also

External links

References

  1. Allen R, Picchietti D, Hening W, Trenkwalder C, Walters A, Montplaisi J (2003). Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health.. Sleep Med 4 (2): 101-19. PMID 14592341.
  2. Allen RP, Walters AS, Montlplaisir J, et al. (2005). Restless legs syndrome prevalence and impact.. Arch Int Med 165: 1286-1292.
  3. http://www.sleepfoundation.org/sleeplibrary/index.php?id=66
  4. Ekbom, K.-A. Restless legs: a clinical study. Acta Med. Scand. (Suppl.) 158: 1-123, 1945.
  5. Connor J, Boyer P, Menzies S, Dellinger B, Allen R, Ondo W, Earley C (2003). Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome.. Neurology 61 (3): 304-9. PMID 12913188.
  6. Desautels A, Turecki G, Montplaisir J, Sequeira A, Verner A, Rouleau G (2001). Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q.. Am J Hum Genet 69 (6): 1266-70. PMID 11704926.
  7. Levchenko A, Montplaisir J, Dubé M, Riviere J, St-Onge J, Turecki G, Xiong L, Thibodeau P, Desautels A, Verlaan D, Rouleau G (2004). The 14q restless legs syndrome locus in the French Canadian population.. Ann Neurol 55 (6): 887-91. PMID 15174026.
  8. Mayo Clinic Algorithm also available as .pdf

Sources

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