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Radioligand

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A radioligand is a radioactive biochemical substance (in particular, a ligand) that is used for diagnosis or for research-oriented study of the receptor systems of the body.

The radioligand is injected into the pertinent tissue, or infused into the bloodstream. It binds to its receptor. When the radioactive isotope in the ligand decays it can be measured, e.g., by positron emission tomography.

The transport of the radioligand is described by receptor kinetics.

HistoryEdit

Radioligands are acredited for making possible the study of biomolecular behaviour, a previously mysterious area of research that had evaded researchers.[1] With this capacity radioligand techniques enabled researchers to identify receptor devices within cells.

Radioactive isotopes commonly usedEdit

List of radioligands Edit


See also Edit

References Edit

  1. Niehoff, Debra (2005). The Language of Life: How cells communicate in life & disease, Joseph Henry Press.
  2. Karen H. Adams, Lars H. Pinborg, Claus Svarer, S. G. Hasselbalch, Søren Holm, Steven Haugbøl, K. Madsen, Vibe G. Frøkjær, L. Martiny Olaf B. Paulson, Gitte Moos Knudsen (March 2004). A database of [18F]-altanserin binding to 5-HT2A receptors in normal volunteers: normative data and relationship to physiological and demographic variables. NeuroImage 21 (3): 1105-1113.

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