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Raclopride

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Raclopride chemical structure
Raclopride

3,5-dichloro-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-2-hydroxy-6-methoxybenzamide
IUPAC name
CAS number
84225-95-6
ATC code

none[1]

PubChem
3033769
DrugBank
[2]
Chemical formula {{{chemical_formula}}}
Molecular weight 347.236 g/mol
Bioavailability
Metabolism
Elimination half-life 30 min
Excretion
Pregnancy category
Legal status
Routes of administration

Raclopride is a synthetic compound that acts as an antagonist on D2 dopamine receptors.[1] It can be radiolabelled with the carbon-11 radioisotope and used in positron emission tomography (PET) scanning to assess the degree of dopamine binding to the D2 Dopamine receptor. For example, one study found decreasing binding with the personality trait detachment.[2]

ReferencesEdit

  1. C. Kohler, H. Hall, S. O. Ogren, L. Gawell (July 1985). Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain. Biochemical Pharmacology 34 (13): 2251–2259.
  2. Lars Farde, J. Petter Gustavsson, Erik Jönsson (February 1997). D2 dopamine receptors and personality traits. Nature 385 (6617): 590.

External linksEdit



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